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Perinephric myxoid pseudotumor of fat: a multimodality imaging case series

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A Correction to this article was published on 17 February 2023

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Abstract

Perinephric myxoid pseudotumor of fat (PMPF) is an unusual clinical entity with few prior imaging case reports. We report a multimodality imaging case series of PMPF, consisting of four cases seen in our department with both imaging studies and histopathologic confirmation. Three of the four patients had a history of advanced non-neoplastic renal disease. The perirenal masses in these cases varied in size and appearance. Some lesions resembled cysts or contained macroscopic fat. Enhancement was equivocal on CT, but prominent in one case on MRI and in another on contrast-enhanced ultrasound. Although not known to be malignant, PMPF may be confused for a cyst, liposarcoma, or hypovascular solid neoplasm on imaging. The dominant mass was resected in two cases because of concern for malignancy, while percutaneous CT-guided biopsy was performed in the other two. Mouse double minute 2 (MDM2) gene amplification by fluorescence in situ hybridization (FISH) was negative in all four cases, excluding well-differentiated liposarcoma. Radiologists should be familiar with PMPF to provide appropriate guidance on clinical management.

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Authors and Affiliations

  1. Department of Radiology, Keck School of Medicine of USC, Los Angeles, CA, USA

    Justin Lee

  2. Department of Radiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA

    Kevin G. King

  3. Department of Pathology, Keck School of Medicine of USC, Los Angeles, CA, USA

    Shefali Chopra

  4. Department of Radiology, Keck School of Medicine of USC, 1441 Eastlake Ave., Suite 2315B, Los Angeles, CA, 90033, USA

    Phillip M. Cheng

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  1. Justin Lee
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  2. Kevin G. King
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Contributions

JL, MD: Material Preparation, Writing. KGK, MD: Material Preparation, Writing. SC, MD: Material Preparation, Writing. PMC, MD MS: Project Administration, Material Preparation, Writing.

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Correspondence to Phillip M. Cheng.

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The authors have no conflicts of interests to declare that are relevant to the content of this article. No funding was received to assist with the preparation of this manuscript.

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Approval by the institutional review board at the Keck School of Medicine of USC was obtained for retrospective data collection and analysis in this study. The requirement for informed consent was waived.

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The original online version of this article was revised: The figures part labels were missing, and figures 7 and 8 were switched. In the visual abstract, citation information was missing. However, the visual abstract and all figures part lables are corrected.

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Lee, J., King, K.G., Chopra, S. et al. Perinephric myxoid pseudotumor of fat: a multimodality imaging case series. Abdom Radiol 48, 1820–1830 (2023). https://doi.org/10.1007/s00261-022-03662-7

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  • DOI: https://doi.org/10.1007/s00261-022-03662-7

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