Abstract
An 81-year-old woman who had undergone total thyroidectomy for papillary thyroid cancer 12 years earlier was found to have a tumor in the tail of the pancreas. Four years earlier, skin, lung, and mediastinal lymph node metastases had appeared. Computed tomography (CT) showed a mass 26 mm in diameter in the tail of the pancreas. Thereafter, the pancreatic tumor increased in size, while the lung metastases remained stable. Unenhanced CT at the time of first detection showed that the tumor was heterogeneous, with low-attenuation areas indicating fat components. As the tumor grew, the fat components became unclear. Laparoscopic distal pancreatectomy and splenectomy were performed. The tumor was diagnosed as dedifferentiated liposarcoma with a well-differentiated liposarcoma component at the tumor margin. The pancreas is an extremely rare site of primary liposarcoma. In the present case, a pancreatic liposarcoma appeared during follow-up of thyroid cancer, and the changes over time were able to be observed with CT.
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Mack TM (1995) Sarcomas and other malignancies of soft tissue, retroperitoneum, peritoneum, pleura, heart, mediastinum, and spleen. Cancer. 75(1 Suppl):211-244. https://doi.org/https://doi.org/10.1002/1097-0142(19950101)75:1+<211::aid-cncr2820751309>3.0.co;2-x
Elliott TE, Albertazzi VJ, Danto LA (1980) Pancreatic liposarcoma: case report with review of retroperitoneal liposarcomas. Cancer. 45(7):1720-1723. https://doi.org/https://doi.org/10.1002/1097-0142(19800401)45:7<1720::aid-cncr2820450733>3.0.co;2-z
Dodo IM, Adamthwaite JA, Jain P, Roy A, Guillou PJ, Menon KV (2005) Successful outcome following resection of a pancreatic liposarcoma with solitary metastasis. World J Gastroenterol. 11(48):7684-7685. https://doi.org/https://doi.org/10.3748/wjg.v11.i48.7684
Kuramoto K, Hashimoto D, Abe S, Chikamoto A, Beppu T, Iyama K, Baba H (2013) Education and imaging. Hepatobiliary and pancreatic: large pancreatic liposarcoma. J Gastroenterol Hepatol. 28(12):1800. https://doi.org/10.1111/jgh.12433
Machado MC, Fonseca GM, de Meirelles LR, Zacchi FF, Bezerra RO (2016) Primary liposarcoma of the pancreas: A review illustrated by findings from a recent case. Pancreatology. 16(5):715-718. https://doi.org/https://doi.org/10.1016/j.pan.2016.07.003
Matthews M, Nelson S, Hari D, French S (2016) Well differentiated liposarcoma, sclerosing type, of the pancreas a case report. Exp Mol Pathol. 101(3):320-322. https://doi.org/https://doi.org/10.1016/j.yexmp.2016.11.002
Han T, Luan Y, Xu Y, Yang X, Li J, Liu R, Li Q, Zheng Z (2017) Successful treatment of advanced pancreatic liposarcoma with apatinib: A case report and literature review. Cancer Biol Ther. 18(9):635-639. https://doi.org/https://doi.org/10.1080/15384047.2017.1345394
Cao D, Wang J, Guo L (2019) Pancreatic liposarcoma: A rare cause of pancreatic mass in adult. J Gastroenterol Hepatol. 34(8):1275. https://doi.org/https://doi.org/10.1111/jgh.14621
Liu Z, Fan WF, Li GC, Long J, Xu YH, Ma G (2019) Huge primary dedifferentiated pancreatic liposarcoma mimicking carcinosarcoma in a young female: A case report. World J Clin Cases. 7(11):1344–1350. https://doi.org/10.12998/wjcc.v7.i11.1344
Vijay A, Ram L (2015) Retroperitoneal liposarcoma: a comprehensive review. Am J Clin Oncol. 38(2):213-219. https://doi.org/https://doi.org/10.1097/COC.0b013e31829b5667
Song T, Shen J, Liang BL, Mai WW, Li Y, Guo HC (2007) Retroperitoneal liposarcoma: MR characteristics and pathological correlative analysis. Abdom Imaging. 32(5):668-674. https://doi.org/https://doi.org/10.1007/s00261-007-9220-6
Chouairy CJ, Abdul-Karim FW, MacLennan GT (2007) Retroperitoneal liposarcoma. J Urol. 177(3):1145. https://doi.org/https://doi.org/10.1016/j.juro.2006.12.006
Manning MA, Paal EE, Srivastava A, Mortele KJ (2018) Nonepithelial Neoplasms of the Pancreas, Part 2: Malignant Tumors and Tumors of Uncertain Malignant Potential From the Radiologic Pathology Archives. Radiographics. 38(4):1047-1072. https://doi.org/https://doi.org/10.1148/rg.2018170201
Win TT, Jaafar H, Yusuf Y (2014) Relationship of angiogenic and apoptotic activities in soft-tissue sarcoma. South Asian J Cancer. 3(3):171-174. https://doi.org/https://doi.org/10.4103/2278-330X.136799
Shaaban AM, Rezvani M, Tubay M, Elsayes KM, Woodward PJ, Menias CO (2016) Fat-containing Retroperitoneal Lesions: Imaging Characteristics, Localization, and Differential Diagnosis. Radiographics. 36(3):710-734. https://doi.org/https://doi.org/10.1148/rg.2016150149
Henricks WH, Chu YC, Goldblum JR, Weiss SW (1997) Dedifferentiated liposarcoma: a clinicopathological analysis of 155 cases with a proposal for an expanded definition of dedifferentiation. Am J Surg Pathol. 21(3):271-281. https://doi.org/https://doi.org/10.1097/00000478-199703000-00002
Subramaniam S, Callahan J, Bressel M, Hofman MS, Mitchell C, Hendry S, Vissers FL, Van der Hiel B, Patel D, Van Houdt WJ, Tseng WW, Gyorki DE (2021) The role of (18) F-FDG PET/CT in retroperitoneal sarcomas-A multicenter retrospective study. J Surg Oncol. 123(4):1081-1087. https://doi.org/https://doi.org/10.1002/jso.26379
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Tanabe, M., Matsui, H., Higashi, M. et al. Pancreatic liposarcoma: a case report. Abdom Radiol 47, 1912–1916 (2022). https://doi.org/10.1007/s00261-022-03522-4
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DOI: https://doi.org/10.1007/s00261-022-03522-4