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Drug-induced bowel complications and toxicities: imaging findings and pearls

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The use of diverse types of drugs can result in a variety of acute and chronic complications that affect almost any organ. The bowel is one of the organs impacted by the side effects of medications. Imaging frequently plays a crucial role in the detection and characterization of complications occurring in the bowel. They include pseudomembranous colitis or antibiotic-associated colitis; angioedema induced by angiotensin-converting enzyme inhibitors; nonsteroidal anti-inflammatory drug-induced enteropathy; cocaine toxicity; clozapine-induced hypomobility; and bowel toxicity induced by chemotherapeutic agents. It is imperative that radiologists are fully aware of these complications and toxicities as well as the relevant findings. In this way, proper treatment can be implemented immediately. The treatment will involve discontinuation of a drug or a change in regimen.

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The authors gratefully acknowledge Dr. Julajak Limsrivilai for the contribution of this article.


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Correspondence to Sitthipong Srisajjakul.

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Srisajjakul, S., Prapaisilp, P. & Bangchokdee, S. Drug-induced bowel complications and toxicities: imaging findings and pearls. Abdom Radiol 47, 1298–1310 (2022).

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