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The impact of blood pressure on the risk of major bleeding complication after renal transplant biopsy

  • Interventional Radiology
  • Published:
Abdominal Radiology Aims and scope Submit manuscript

Abstract

Purpose

To assess the impact of elevated blood pressure on the rate of major hemorrhagic complication after renal transplant biopsy.

Methods

Pre-procedural systolic (SBP), diastolic (SBP), and mean arterial (MAP) blood pressure for consecutive patients undergoing US-guided renal transplant biopsies from 08/01/2015 to 7/31/2017 were retrospectively recorded. Patients who had a major bleeding complication were identified. The risk of complication as a function of SBP, DBP, and MAP was statistically analyzed, with significance set at p < 0.05.

Results

Of 1689 biopsies, there were 10 bleeding complications (10/1689, 0.59%). There was no statistically significant difference between biopsies with complication compared to those without complication based on SBP (p = 0.351), DBP (p = 0.088), or MAP (p = 0.132). Using risk dichotomization criteria, the odds ratio for hemorrhagic complication when the patient had SBP ≥ 180 mmHg and DBP ≥ 95 mmHg was 75.63 (95% CI 6.87–516.8, p = 0.002).

Conclusion

The rate of hemorrhagic complication from renal transplant biopsy is low, and there is no statistically significant threshold for increased biopsy risk based on SBP, DBP, or MAP alone. The risk of complication was significantly higher only when both the SBP is ≥ 180 mmHg and DBP is ≥ 95 mmHg.

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Data availability

The data that support the findings of this study are available from the corresponding author upon reasonable request.

Abbreviations

SBP:

Systolic blood pressure

DBP:

Diastolic blood pressure

MAP:

Mean arterial pressure

US:

Ultrasound

EMR:

Electronic medical record

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Funding

No funding was received for conducting this study.

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Authors and Affiliations

  1. Department of Radiology, Mayo Clinic Arizona, 5777 E. Mayo Blvd, Phoenix, AZ, 85054, USA

    Winston T. Wang, Anika G. Patel, Scott W. Young, J. Scott Kriegshauser, Nirvikar Dahiya & Maitray D. Patel

  2. Division of Clinical Trials and Biostatistics, Department of Quantitative Health Research, Mayo Clinic Scottsdale, Scottsdale, 85259, USA

    Nan Zhang

Authors
  1. Winston T. Wang
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  2. Anika G. Patel
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  4. Scott W. Young
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  5. J. Scott Kriegshauser
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  6. Nirvikar Dahiya
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  7. Maitray D. Patel
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by MDP, WTW, AGP, and NZ. The first draft of the manuscript was written by MDP; all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Maitray D. Patel.

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Conflict of interest

The authors have no relevant financial or non-financial interests to disclose.

Ethical approval

This retrospective chart review study involving human participants was in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The Human Investigation Committee (IRB) of Mayo Clinic approved this study.

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Wang, W.T., Patel, A.G., Zhang, N. et al. The impact of blood pressure on the risk of major bleeding complication after renal transplant biopsy. Abdom Radiol 47, 409–415 (2022). https://doi.org/10.1007/s00261-021-03282-7

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  • DOI: https://doi.org/10.1007/s00261-021-03282-7

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