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Clinical outcomes of uterine arterial chemoembolization with drug-eluting beads for advanced-stage or recurrent cervical cancer

  • Interventional Radiology
  • Published:
Abdominal Radiology Aims and scope



To study the clinical efficacy and safety of transarterial chemoembolization with drug-eluting beads (DEB-TACE) among women with advanced-stage or recurrent cervical cancer.


This retrospective cohort study enrolled women with cervical cancer who were treated by DEB-TACE between April 3, 2017 and July 12, 2021. Inclusion criteria were pathologic diagnosis of cervical cancer, II–IVa period, being aged 18 to 80 years, patient's inclination of treatment with DEB-TACE, and complete clinicopathologic data. Direct medical cost, hospital stay, resection frequency, treatment responses, adverse events, overall survival, and progression-free survival were investigated.


A total of 16 women with cervical cancer were treated by DEB-TACE. DEB-TACE was successfully performed in all patients, with no major complications or adverse events. A total of 10 minor complications were observed in 9 women (56.3%) after the procedure. Seven (43.8%) women experienced mild to moderate post-embolization pain. The tumors decreased 3 and 6 months after the treatment. The frequency of complete response, partial response, stable disease, and progressive disease was 1 (40%), 3 (40%), 12 (15%), and 0 (0%), respectively, resulting in an objective response rate of 25.0% and a disease control rate of 100.0% after 1 month. The median hospital stay was 9.5 days, and the direct medical cost was 5.9 × 104 ¥. The median follow-up time was 4.1 months (interquartile range 2.6–23.7 months). The median overall survival was 19.1 months, and the 1- and 3-year survival rate was 64.9% and 46.4%, respectively.


DEB-TACE with diamminedichloroplatinum-preloaded beads may be an effective and safe treatment for women with advanced-stage or recurrent cervical cancer.

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Authors and Affiliations



Concept and design: XH and JR; data collection: YB, XS, YW, and MX; manuscript drafting: YB, YW, and JZ; statistical analysis: YB and YW; administrative support: XH and JR. All authors discussed the results and revised the manuscript.

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Correspondence to Xinwei Han or Jianzhuang Ren.

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The authors declare that they have no conflict of interest.

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This study was approved by the Ethics Committee of The First Affiliated Hospital of Zhengzhou University.

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Written informed consent was waived due to its retrospective nature.

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Written informed consents were obtained from the patients for publication. A copy of the written consent is available for review by the Editor of this journal.

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Bi, Y., Wang, Y., Zhang, J. et al. Clinical outcomes of uterine arterial chemoembolization with drug-eluting beads for advanced-stage or recurrent cervical cancer. Abdom Radiol 46, 5715–5722 (2021).

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