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Clinical outcomes of uterine arterial chemoembolization with drug-eluting beads for advanced-stage or recurrent cervical cancer

  • Interventional Radiology
  • Published:
Abdominal Radiology Aims and scope Submit manuscript

Abstract

Purpose

To study the clinical efficacy and safety of transarterial chemoembolization with drug-eluting beads (DEB-TACE) among women with advanced-stage or recurrent cervical cancer.

Methods

This retrospective cohort study enrolled women with cervical cancer who were treated by DEB-TACE between April 3, 2017 and July 12, 2021. Inclusion criteria were pathologic diagnosis of cervical cancer, II–IVa period, being aged 18 to 80 years, patient's inclination of treatment with DEB-TACE, and complete clinicopathologic data. Direct medical cost, hospital stay, resection frequency, treatment responses, adverse events, overall survival, and progression-free survival were investigated.

Results

A total of 16 women with cervical cancer were treated by DEB-TACE. DEB-TACE was successfully performed in all patients, with no major complications or adverse events. A total of 10 minor complications were observed in 9 women (56.3%) after the procedure. Seven (43.8%) women experienced mild to moderate post-embolization pain. The tumors decreased 3 and 6 months after the treatment. The frequency of complete response, partial response, stable disease, and progressive disease was 1 (40%), 3 (40%), 12 (15%), and 0 (0%), respectively, resulting in an objective response rate of 25.0% and a disease control rate of 100.0% after 1 month. The median hospital stay was 9.5 days, and the direct medical cost was 5.9 × 104 ¥. The median follow-up time was 4.1 months (interquartile range 2.6–23.7 months). The median overall survival was 19.1 months, and the 1- and 3-year survival rate was 64.9% and 46.4%, respectively.

Conclusion

DEB-TACE with diamminedichloroplatinum-preloaded beads may be an effective and safe treatment for women with advanced-stage or recurrent cervical cancer.

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Data availability

For further details, the corresponding author can be contacted.

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Author notes

  1. Yonghua Bi and Yanli Wang contributed equally to this work and share co-first authorship.

Authors and Affiliations

  1. Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, No. 1, East Jian She Road, Zhengzhou, 450052, China

    Yonghua Bi, Yanli Wang, Jianhao Zhang, Yang Wang, Miao Xu, Xinwei Han & Jianzhuang Ren

  2. Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

    Xiaonan Shi

Authors
  1. Yonghua Bi
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  2. Yanli Wang
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  3. Jianhao Zhang
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  4. Xiaonan Shi
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  5. Yang Wang
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  6. Miao Xu
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  7. Xinwei Han
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  8. Jianzhuang Ren
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Contributions

Concept and design: XH and JR; data collection: YB, XS, YW, and MX; manuscript drafting: YB, YW, and JZ; statistical analysis: YB and YW; administrative support: XH and JR. All authors discussed the results and revised the manuscript.

Corresponding authors

Correspondence to Xinwei Han or Jianzhuang Ren.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This study was approved by the Ethics Committee of The First Affiliated Hospital of Zhengzhou University.

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Written informed consent was waived due to its retrospective nature.

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Written informed consents were obtained from the patients for publication. A copy of the written consent is available for review by the Editor of this journal.

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Bi, Y., Wang, Y., Zhang, J. et al. Clinical outcomes of uterine arterial chemoembolization with drug-eluting beads for advanced-stage or recurrent cervical cancer. Abdom Radiol 46, 5715–5722 (2021). https://doi.org/10.1007/s00261-021-03267-6

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  • DOI: https://doi.org/10.1007/s00261-021-03267-6

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