Abstract
Purpose
To show utility of tadalafil in enhancing visualization of posterior urethra in patients with urethral stricture.
Methods
We retrospectively reviewed the records of adults male who failed to delineate the posterior urethra while undergoing combined voiding cystourethrogram and retrograde urethrogram (VCUG and RUG), as a part of preoperative assessment of stricture length and location before urethral reconstruction.
The study was repeated 24 h later after a single dose of tadalafil 20 mg was administrated 2 h before the procedure (Tadalafil group). A control group who did not receive any medication was used for comparison (control group). This study was carried out in between March 2016 and August 2019.
Results
Thirty patients were included in the tadalafil group and equal number of patients was used as control group for comparison. The etiologies of strictures were pelvic fracture urethral distraction defect (39 patients), bulbar stricture with complete obliteration (15 patients) and post catheterization (6 patients).
Success rate of opening bladder outlet on initiation of voiding was 90% in tadalafil group and 40% in the control group (P = 0.0004). None of the men reported any serious adverse events after oral administration of the drug. Almost all AEs were mild and well-tolerated.
Conclusion
Tadalafil effectively relaxes the bladder neck and the posterior urethra prior to combined VCUG and RUG in urethral stricture patients. Tadalafil was safe with no serious adverse effects when administered prior to performing the test. This prevents the patients from undergoing further invasive or expensive diagnostic techniques, moreover, tadalafil assisted in preoperative surgical preparation and patient's counseling.
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Abbreviations
- VCUG:
-
Combined voiding cystourethrogram
- RUG:
-
Retrograde urethrogram
- PFUDD:
-
Pelvic fracture urethral distraction defect
- PDE5-Is:
-
Phosphodiesterase type 5 inhibitors
- ED:
-
Erectile dysfunction
- LUTS:
-
Lower urinary tract symptoms
References
Breyer BN, Cooperberg MR, McAninch JW, Master VA (2009) Improper retrograde urethrogram technique leads to incorrect diagnosis. J Urol.182 (2):716-717.
Maciejewski C, Rourke K. Imaging of urethral stricture disease (2015) Translational Androl Urol. Feb; 4(1):2.
Porst, H.; Kim, E.D.; Casabé, A.R.; Mirone, V.; Secrest, R.J.; Xu, L.; Sundin, D.P.; Viktrup, L. LVHJ Study Team (2011) Efficacy and safety of tadalafil once daily in the treatment of men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia: Results of an international randomized, double-blind, placebo-controlled trial. Eur. Urol. 60, 1105-1113.
Gacci, M.; Andersson, K.E.; Chapple, C.; Maggi, M.; Mirone, V.; Oelke, M.; Porst, H.; Roehrborn, C.; Stief, C.; Giuliano, F (2016) Latest Evidence on the Use of Phosphodiesterase Type 5 Inhibitors for the Treatment of Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia. Eur. Urol. 70, 124-133.
Filippi, S.; Morelli, A.; Sandner, P.; Fibbi, B.; Mancina, R.; Marini, M.; Gacci, M.; Vignozzi, L.; Vannelli, G.B.; Carini, M.; et al (2007) Characterization and functional role of androgen dependent PDE5 activity in the bladder. Endocrinology 148, 1019-1029.
Oelke, M.; Giuliano, F.; Mirone, V.; Xu, L.; Cox, D.; Viktrup, L (2012) Monotherapy with tadalafil or tamsulosin similarly improved lower urinary tract symptoms suggestive of benign prostatic hyperplasia in an international, randomised, parallel, placebo-controlled clinical trial. Eur. Urol. 61, 917-925.
Laydner, H.K.; Oliveira, P.; Oliveira, C.R.; Makarawo, T.P.; Andrade, W.S.; Tannus, M.; Araújo, J.L (2011) Phosphodiesterase 5 inhibitors for lower urinary tract symptoms secondary to benign prostatic hyperplasia: A systematic review. BJU Int. 107, 1104-1109.
Roehrborn, C.G.; Chapple, C.; Oelke, M.; Cox, D.; Esler, A.; Viktrup, L (2014) Effects of tadalafil once daily on maximum urinary flow rate in men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia. J. Urol. 191, 1045.
S.M. Goldman, C.M. Sandler, J.N. Corriere Jr, E.J. McGuire (1997) Blunt urethral trauma: a unified, anatomical mechanical classification J. Urol., 157 , pp. 85-89
Gallentine M.L., and Morey A.F (2002) Imaging of the male urethra for stricture disease. Urol Clin North Am 29: pp. 361-372.
Sung DJ, Kim YH, Cho SB, Oh YW, Lee NJ, Kim JH, et al. (2006) Obliterative urethral stricture: MR urethrography versus conventional retrograde urethrography with voiding cystourethrography. Radiology. 240:842-48.
Goel A, Gupta A, Dalela D (2009) Antegrade urethrogram: A technique to visualize the proximal bulbous urethral segment in anterior urethral stricture. Indian J Urol. 25(3):415-416.
Hosseini, S. J., A. Kaviani, et al (2006) Diagnostic application of flexible cystoscope in pelvic fracture urethral distraction defects. Urol J. 3(4): 204-207.
Goel MC, Kumar M, Kapoor R (1997) Endoscopic management of traumatic posterior urethral stricture: Early results and follow-up. J Urol. 157:95-97.
Gong EM, Arellano CM, Chow JS, Lee RS (2010) Sonourethrogram to manage adolescent anterior urethral stricture. J Urol. 184(4 Suppl):1699-1702.
Sung DJ, Kim YH, Cho SB, Oh YW, Lee NJ, Kim JH, et al (2006) Obliterative urethral stricture: MR urethrography versus conventional retrograde urethrography with voiding cystourethrography. Radiology. 240(3):842-848.
Fibbi, B. et al (2010) Characterization of phosphodiesterase type 5 expression and functional activity in the human male lower urinary tract. J. Sex. Med.2010; 7, 59-69.
Nandan R. Pujari, Sanjay B. Kulkarni (2013) The Use of Tamsulosin in Voiding Cystourethrograms for Pelvic Floor Urethral Distraction Injuries. UroToday Int J. 3 August;6(4).
Nagathan DS, Dalela D, Sankhwar S, Goel A, Dwivedi AK, Yadav R (2014) Single dose silodosin prior to voiding cystourethrogram: a pharmacological adjunct to enhance visualization of posterior urethra. Urol J. 11(1):1320-1324.
Francis SH, Corbin JD (2003) Molecular mechanisms and pharmacokinetics of phosphodiesterase-5 antagonists. Curr Urol Rep. 4:457-65.
Briganti A, Salonia A, Gallina A, et al (2005 Drug Insight: oral phospho-diesterase type 5 inhibitors for erectile dysfunction. Nat Clin Pract Urol. 2:239-47.
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The published article complies with the guidelines for human studies and was conducted ethically in accordance with the World Medical Association Declaration of Helsinki. Approval for the study was obtained from the Alexandria Faculty of Medicine ethical committee (File number and date, 128:06-2016).
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Fahmy, A., Elgebaly, O., Elsawy, M.M. et al. Role of tadalafil in enhancing visualization of posterior urethra prior to combined voiding cystourethrogram and retrograde urethrogram: a retrospective analysis. Abdom Radiol 46, 4332–4337 (2021). https://doi.org/10.1007/s00261-021-03109-5
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DOI: https://doi.org/10.1007/s00261-021-03109-5