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Change in hepatic volume profile in potential live liver donors after lifestyle modification for reduction of hepatic steatosis

  • Hepatobiliary
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Abstract

Purpose

We aimed to evaluate changes in hepatic volume and hemiliver volume percentage in potential liver donors after hepatic steatosis (HS) reduction through lifestyle modification.

Methods

Fifty liver donor candidates with HS (macrovesicular fat [MaF] ≥ 20%) underwent abdominal computed tomography (CT) and liver biopsy before (baseline) and after (follow-up) lifestyle modification. According to the change in MaF, subjects were classified as group A (MaF reduction ≥ 20%, n = 25), and group B (MaF reduction < 20%, n = 25). The hepatic volume and hemiliver volume percentage were measured using CT volumetric analysis.

Results

Volume percentage of the left hemiliver + S1 (over the whole liver) significantly increased at follow-up in group A (P < 0.001) but not in group B (P = 0.598). The absolute volume change of the right hemiliver and its percentage change from the baseline were significantly greater than those of the left hemiliver + S1 in group A (P < 0.007). There were no significant differences in these values in group B (P = 0.064 and 0.507, respectively). The percentage of subjects that earned the benefit of becoming suitable donors from the change in hepatic volume distribution caused by HS improvement was 52.0% (13/25) and 40.0% (10/25) in group A and group B, respectively. Regarding posthepatectomy liver failure, none was identified in group A after donation, whereas 12% (3/25) was identified in group B.

Conclusion

Hepatic volume profile may change considerably in potential liver donors with HS (MaF ≥ 20%) after HS reduction through lifestyle modification. Reevaluation of the hepatic volume is required before liver procurement after lifestyle modification in these subjects.

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Data availability

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Funding

This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Science, ICT and Future Planning (No. 2017R1E1A1A03070961).

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Authors and Affiliations

  1. Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, 88 Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Republic of Korea

    Hyo Jung Park & Kyoung Won Kim

  2. School of Computer Science and Engineering, Soongsil University, Seoul, Republic of Korea

    Jeongjin Lee & Taeyong Park

  3. Department of Radiology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

    Heon-Ju Kwon

  4. Division of Liver Transplantation and Hepatobiliary Surgery, Departments of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea

    Gi-Won Song & Sung-Gyu Lee

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  1. Hyo Jung Park
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Contributions

The study concept and design were developed by KWK. HJP, KWK, G-WS, S-GL contributed to the acquisition of data. HJP, KWK, JL, TP, and H-JK contributed to the analysis and interpretation of data, drafting of the manuscript, and statistical analysis. KWK, G-WS, and S-GL contributed to the revision of the manuscript and study supervision. All authors had full access to all data in the study and have critically reviewed the article for important intellectual content.

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Correspondence to Kyoung Won Kim.

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Park, H.J., Kim, K.W., Lee, J. et al. Change in hepatic volume profile in potential live liver donors after lifestyle modification for reduction of hepatic steatosis. Abdom Radiol 46, 3877–3888 (2021). https://doi.org/10.1007/s00261-021-03058-z

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  • DOI: https://doi.org/10.1007/s00261-021-03058-z

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