Abstract
Splenic lesions in children have a wide histological spectrum. The majority of pediatric splenic lesions are benign and detected incidentally, and the most common benign lesions are cysts, followed by hemangiomas and lymphatic malformations. Most of the splenic malignancies in children are secondary to leukemia or lymphoma. The purpose of this article is to describe the ultrasonography, computed tomography (CT), and magnetic resonance imaging (MRI) features of benign and malignant splenic lesions in the pediatric age group.
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Kamaya A, Weinstein S, Desser TS (2006) Multiple lesions of the spleen: differential diagnosis of cystic and solid lesions. Semin Ultrasound CT MRI 27: 389-403. https://doi.org/10.1053/j.sult.2006.06.004
Jang KM, Kim SH, Hwang J, Lee SJ, Kang TW, Lee MW, et al (2014) Differentiation of malignant from benign focal splenic lesions: added value of diffusion-weighted MRI. AJR Am J Roentgenol 203: 803-14. https://doi.org/10.2214/AJR.13.11914
Dhyani M, Anupindi SA, Ayyala R, Hahn PF, Gee MS (2013) Defining an imaging algorithm for noncystic splenic lesions identified in young patients. AJR Am J Roentgenol 201: 893-99. https://doi.org/10.2214/AJR.12.10105
Urrutia M, Mergo PJ, Ros LH, Torres GM, Ros PR (1996) Cystic masses of the spleen: radiologic-pathologic correlation. RadioGraphics 16: 107-29. https://doi.org/10.1148/radiographics.16.1.107
Caremani M, Occhini U, Caremani A, Tacconi, D, Lapini L, Accorsi A, et al (2013) Focal splenic lesions: US findings. J Ultrasound 16: 65-74. https://doi.org/10.1007/s40477-013-0014-0
Giovagnoni A, Giorgi C, Goteri G (2005) Tumours of the spleen. Cancer Imaging 5: 73-7. https://doi.org/10.1102/1470-7330.2005.0002
Yoo E, Kim MJ, Kim KW, Chung JJ, Kim SH, Choi JY (2006) A case of mesenteric cystic lymphangioma: fat saturation and chemical shift MR imaging. J Magn Reson Imaging 23: 77-80. https://doi.org/10.1002/jmri.20474
Taibbi A, Bartolotta TV, Matranga D, Midiri M, Lagalla R (2012) Splenic hemangiomas: contrast-enhanced sonographic findings. J Ultrasound Med. 2012 31:543-53. https://doi.org/10.7863/jum.2012.31.4.543
Ozcan HN, Oguz B, Talim B, Ekinci S, Haliloglu M (2014) Unusual splenic hemangioma of a pediatric patient: hypointense on T2-weighted image. Clinical Imaging 38: 553-55. https://doi.org/10.1016/j.clinimag.2014.02.007
Abbott RM, Levy AD, Aguilera NS, Gorospe L, Thompson WM (2004) Primary vascular neoplasms of the spleen: radiologic-pathologic correlation. RadioGraphics 24: 1137-63. https://doi.org/10.1148/rg.244045006
Yan J, Peng C, Yang W, Wu C, Ding J, Shi T, et al (2008) Inflammatory pseudotumour of the spleen: report of 2 cases and literature review. Can J Surg 51: 75-6
Thacker C, Korn R, Millstine J, Harvin H, Ribbink JAVL, Gotway M (2010) Sclerosing angiomatoid nodular transformation of the spleen: CT, MR, PET, and 99m Tc-sulfur colloid SPECT CT findings with gross and histopathological correlation. Abdom Imaging 35: 683-89. https://doi.org/10.1007/s00261-009-9584-x
Li M, Zhang L, Wu N, Huang W, Lv N (2013) Imaging findings of primary splenic lymphoma: a review of 17 cases in which diagnosis was made at splenectomy. Plos One 8: 80264. https://doi.org/10.1371/journal.pone.0080264
Saboo SS, Krajewski KM, O'Regan KN, Giardino A, Brown JR, Ramaiya N, et al (2012) Spleen in haematological malignancies: spectrum of imaging findings. Br J Radiol 85: 81-92. https://doi.org/10.1259/bjr/31542964
Serrano OK, Knapp E, Huang K, Baran G, Statter M, McClain D, Gill J (2014) Pediatric primary splenic angiosarcoma: an aggressive multidisciplinary approach to the oncologic management of a rare malignancy. World J Surg Oncol 12:1-7. https://doi.org/10.1186/1477-7819-12-379
Hadidy A, Alsharif A, Sheikh-Ali R, Abukhalaf M, Awidi A, Abukaraki A, Omari A (2010) Odontogenic myxofibroma synchronous with primary angiosarcoma of the spleen. Br J Radiol 83:10-13. https://doi.org/10.1259/bjr/14078580
Kaneko K, Onitsuka H, Murakami J, Honda H, Kimura M, Shiraishi N, et al (1992) MRI of primary spleen angiosarcoma with iron accumulation. J Comput Assist Tomogr 16: 298-300
Vrachliotis TG, Bennett WF, Vaswani KK, Niemann TH, Bova JG (2000) Primary angiosarcoma of the spleen: CT, MRI and sonographic characteristics—report of two cases. Abdom Imaging 25: 283-85. https://doi.org/10.1007/s002610000034
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Concept/Design: OOY, HNO, MH. Literature Search: OOY, HNO, TTC. Data Acquisition: OOY, EA, HNO, BO, SE, TTC. Writing: OOY. Critical Revision: HNO, BO, MH. Final Approval: All of authors.
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Ozkale Yavuz, O., Ozcan, H.N., Oguz, B. et al. Imaging findings of benign and malignant pediatric splenic lesions. Abdom Radiol 46, 3245–3252 (2021). https://doi.org/10.1007/s00261-021-03004-z
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DOI: https://doi.org/10.1007/s00261-021-03004-z