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Intra- inter-observer repeatability in liver computed tomography volumetry in patients undergoing radioembolization simulation

  • Interventional Radiology
  • Published:
Abdominal Radiology Aims and scope Submit manuscript

Abstract

Purpose

The careful evaluation of MDCT is an essential step for the treatment planning in pre-treatment imaging work-up for Trans-Arterial Radio Embolization (TARE). It may provide unique volumetric data (CTVs), which are information useful for an effective and safe TARE. The purpose of this study is to demonstrate that the radiographer is able to calculate CTVs of TARE simulation with the same precision as the interventional radiologist.

Methods

This study retrospectively considers 17 consecutive patients (8 males, 9 females; mean age 66.3 ± 13.2 years) who underwent pre-treatment work-up for TARE, between May 2019 and February 2020 (trial ID:2234 - protocol). For each patient, four specific parameters are evaluated from MDCT achieved during treatment simulation: healthy liver volume (HLV), the whole hepatic parenchyma (THV = healthy liver and TTV = tumour) involved by TARE, and whole liver volume (WLV). Four independent observers—R1 (expert interventional radiologist), T1, T2, and T3 (radiographers, with different experiences in the field of interventional radiology)—are involved in the imaging analysed.

Results

All the 4 observers detected the same number of hepatic lesion(s) per patient. Regarding the three radiographers, the intra-observer reliability for CTVs is very high 0.997 to 1.000 (95%CI). Also inter-observer reproducibility between radiographers is excellent regarding CTVs, 0.965 to 0.999 (95%CI). The accuracy of radiographer evaluation is very high 0.964 to 0.999 (95%CI).

Conclusions and implications for practice

The high intra- and inter-observer reproducibility shows that a properly trained radiographers might have the same accuracy as interventional radiologists, in assessing liver CTV data for planning TARE.

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Funding

This work was partially supported by the Italian Ministry of Health with Ricerca Corrente and 5x1000 founds and by Fondazione IEO-CCM.

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Authors and Affiliations

  1. Division of Radiology, IEO European Institute of Oncology IRCCS, Via Giuseppe Ripamonti 435, Milan, 20141, Italy

    Andrea Masperi, Valerio Cubadda, Luca Bombelli, Roberto Labruna & Cristiana Iuliana Fodor

  2. Department of Statistics and Quantitative Methods, University of Milan-Bicocca, Milan, Italy

    Vincenzo Bagnardi & Eleonora Pagan

  3. Division of Interventional Radiology, IEO European Institute of Oncology IRCCS, Via Giuseppe Ripamonti 435, Milan, 20141, Italy

    Guido Bonomo & Franco Orsi

Authors
  1. Andrea Masperi
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  2. Valerio Cubadda
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  3. Luca Bombelli
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  4. Roberto Labruna
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  5. Vincenzo Bagnardi
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  6. Cristiana Iuliana Fodor
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  7. Eleonora Pagan
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  8. Guido Bonomo
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  9. Franco Orsi
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Contributions

Conceptualization: AM, FO, VB, Methodology: AM, VC, LB, GB, Formal analysis and investigation: CIF, RL, VB, EP, Writing—original draft preparation: AM, LB, Writing—review and editing: AM, LB, FO, Supervision: CIF, RL, FO

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Correspondence to Andrea Masperi.

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Masperi, A., Cubadda, V., Bombelli, L. et al. Intra- inter-observer repeatability in liver computed tomography volumetry in patients undergoing radioembolization simulation. Abdom Radiol 46, 3448–3455 (2021). https://doi.org/10.1007/s00261-021-02980-6

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  • DOI: https://doi.org/10.1007/s00261-021-02980-6

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