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CT-based radiomics for differentiating renal tumours: a systematic review

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Abstract

Purpose

Differentiating renal tumours into grades and tumour subtype from medical imaging is important for patient management; however, there is an element of subjectivity when performed qualitatively. Quantitative analysis such as radiomics may provide a more objective approach. The purpose of this article is to systematically review the literature on computed tomography (CT) radiomics for grading and differentiating renal tumour subtypes. An educational perspective will also be provided.

Methods

The Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist was followed. PubMed, Scopus and Web of Science were searched for relevant articles. The quality of each study was assessed using the Radiomic Quality Score (RQS).

Results

13 studies were found. The main outcomes were prediction of pathological grade and differentiating between renal tumour types, measured as area under the curve (AUC) for either the receiver operator curve or precision recall curve. Features extracted to predict pathological grade or tumour subtype included shape, intensity, texture and wavelet (a type of higher order feature). Four studies differentiated between low-grade and high-grade clear cell renal cell cancer (RCC) with good performance (AUC = 0.82–0.978). One other study differentiated low- and high-grade chromophobe with AUC = 0.84. Finally, eight studies used radiomics to differentiate between tumour types such as clear cell RCC, fat-poor angiomyolipoma, papillary RCC, chromophobe RCC and renal oncocytoma with high levels of performance (AUC 0.82–0.96).

Conclusion

Renal tumours can be pathologically classified using CT-based radiomics with good performance. The main radiomic feature used for tumour differentiation was texture. Fuhrman was the most common pathologic grading system used in the reviewed studies. Renal tumour grading studies should be extended beyond clear cell RCC and chromophobe RCC. Further research with larger prospective studies, performed in the clinical setting, across multiple institutions would help with clinical translation to the radiologist’s workstation.

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Authors and Affiliations

  1. Townsville University Hospital, 100 Angus Smith Drive, Douglas, QLD, 4814, Australia

    Abhishta Bhandari, Muhammad Ibrahim & Chinmay Sharma

  2. Department of Medical Imaging Research Office, Royal Brisbane and Women’s Hospital, Brisbane, QLD, Australia

    Rebecca Liong, Sonja Gustafson & Marita Prior

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  1. Abhishta Bhandari
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  2. Muhammad Ibrahim
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Correspondence to Abhishta Bhandari.

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Bhandari, A., Ibrahim, M., Sharma, C. et al. CT-based radiomics for differentiating renal tumours: a systematic review. Abdom Radiol 46, 2052–2063 (2021). https://doi.org/10.1007/s00261-020-02832-9

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