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Multiple septae as potential protective factors against spontaneous pyogenic liver abscess rupture: a propensity score matching analysis

  • Hepatobiliary
  • Published:
Abdominal Radiology Aims and scope Submit manuscript

Abstract

Purpose

The symptoms of spontaneous rupture of a pyogenic liver abscess (PLA) are severe and often life-threatening. Multiple septae are important imaging features of PLA. However, the relationship between septation and abscess rupture is still under debate.

Methods

Patients diagnosed with PLA from January 2011 to November 2019 in our hospital were included. We collected demographic, clinical, and computed tomography data. Univariate and multivariate analyses determined liver abscess rupture risk factors. The relationship between multiple septae and abscess rupture was evaluated by propensity score matching after matching other influencing factors.

Results

A total of 583 patients of pyogenic liver abscesses were included in the study: 30 ruptured and 553 unruptured. Multivariate analysis revealed diabetes, single lesion, gas formation, left hepatic lobe location, and a diameter > 66.5 mm as independent risk factors for ruptures, while multiple septae were identified as a protective factor. After matching all the influencing factors (excluding multiple septae), multiple septae and abscess rupture maintain a negative relationship.

Conclusions

Multiple septae were identified as a potentially protective factor against spontaneous pyogenic liver abscess ruptures.

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Funding

This study was funded by National Natural Science Foundation of China (Grant No. 81901856), 345 Talent Project in Shengjing Hospital of China Medical University.

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Authors and Affiliations

  1. Department of Radiology, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Heping District, Shenyang, 110004, China

    Hairui Wang, Yue Ren, Zhaoyu Liu & Zhihui Chang

Authors
  1. Hairui Wang
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  2. Yue Ren
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  3. Zhaoyu Liu
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Corresponding author

Correspondence to Zhihui Chang.

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Wang, H., Ren, Y., Liu, Z. et al. Multiple septae as potential protective factors against spontaneous pyogenic liver abscess rupture: a propensity score matching analysis. Abdom Radiol 46, 992–997 (2021). https://doi.org/10.1007/s00261-020-02758-2

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  • DOI: https://doi.org/10.1007/s00261-020-02758-2

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