CT and MR imaging of chemotherapy-induced hepatopathy


Chemotherapy-induced hepatopathy includes a wide variety of parenchymal and vascular hepatic changes on imaging, including diffuse or focal hepatopathies (i.e. hepatitis, steatosis, fibrosis, pseudocirrhosis, or sinusoidal obstruction). These changes can profoundly alter the hepatic parenchyma on imaging and result in both false negative and false-positive diagnoses of hepatic metastases and lead to errors in patient management strategies. It is therefore important for radiologists to have a comprehensive knowledge of the imaging patterns that may develop following chemotherapy. The purpose of this review is to explore the broad spectrum of hepatic parenchymal and vascular chemotherapy-induced changes on CT and MR imaging.

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Correspondence to Federica Vernuccio.

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FV, M.D.B., F.B., S.C., G. Badalamenti, M.M., V.V.: Nothing to disclose. G. Brancatelli: has received lecture fees from Bayer.

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Vernuccio, F., Dioguardi Burgio, M., Barbiera, F. et al. CT and MR imaging of chemotherapy-induced hepatopathy. Abdom Radiol 44, 3312–3324 (2019). https://doi.org/10.1007/s00261-019-02193-y

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  • Chemotherapy
  • Hepatopathy
  • Computed tomography
  • Magnetic resonance imaging
  • Sinusoidal obstruction syndrome