Overview of imaging findings associated with systemic therapies in advanced epithelial ovarian cancer

  • Ezgi GulerEmail author
  • Daniel A. Smith
  • Bhanusupriya Somarouthu
  • Rahul Gujrathi
  • Nikhil H. Ramaiya
  • Sree Harsha Tirumani



To provide an overview for radiologists of the systemic agents used in the treatment of advanced epithelial ovarian cancer (EOC) and their associated toxicities.


EOC is a common gynecological malignancy, with the majority of patients presenting with advanced stage disease at the time of diagnosis. Although primary cytoreductive surgery and chemotherapy are the principal treatments for EOC, recurrence rates of disease remain high. As several molecular targeted therapies have been developed in the last decade, various novel agents have shown efficacy in the treatment of advanced EOC. Advanced EOC will be discussed by outlining the relevant radiological features of toxicities.


Knowledge of the systemic therapies utilized in the treatment of advanced EOC and their associated radiological features is critical in diagnostic image interpretation.


Epithelial ovarian cancer Epithelial ovarian carcinoma Systemic therapies 


Compliance with ethical standards

Conflict of interest

The authors declare that there are no conflicts of interest regarding this article.


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Authors and Affiliations

  1. 1.Department of RadiologyUniversity Hospitals Cleveland Medical CenterClevelandUSA
  2. 2.Department of Radiology, Harvard Medical SchoolMassachusetts General HospitalBostonUSA
  3. 3.Department of Radiology, Harvard Medical SchoolDana-Farber Cancer InstituteBostonUSA

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