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Microvascular invasion and grading in hepatocellular carcinoma: correlation with major and ancillary features according to LIRADS

Abdominal Radiology volume 44, pages 2788–2800 (2019)Cite this article

Abstract

Purpose

To assess major and ancillary parameters that could be correlated with Microvascular Invasion (MIV) and with histologic grade of HCC.

Materials and methods

In this retrospective study, we assessed 62 patients (14 women–48 men; mean age, 63 years; range 38–80 years) that underwent hepatic resection for HCC. All patients were subject to Multidetector computed tomography (MDCT); 40 to Magnetic Resonance (MR) study. The radiologist assessed major and ancillary features according to LIRADS (v. 2018) and reported any radiological accessory findings if detected.

Results

No major feature showed statistically significant differences and correlation with grading. Mean ADC value was correlated with grading and with MIV status. No major feature was correlated to MIV; progressive contrast enhancement and satellite nodules showed statistically different percentages with respect to the presence of MIV, so as at the monovariate correlation analysis, satellite nodules were correlated with the presence of MIV. At multivariate regression analysis, no factor proved to be strong predictors of grading while progressive contrast enhancement and satellite nodules were significantly associated with the MIV.

Conclusion

Mean ADC value is correlated to HCC grading and MIV status. Progressive contrast enhancement and the presence of satellite nodules are correlated to MIV status.

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Acknowledgements

The authors are grateful to Alessandra Trocino, librarian at the National Cancer Institute of Naples, Italy. Moreover, for the collaboration, authors are grateful to Assunta Zazzaro and Dr Ivano Rossi, TSRM at Radiology Division, “Istituto Nazionale Tumori IRCCS Fondazione Pascale – IRCCS di Napoli,” Naples, I-80131, Italy.

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Affiliations

  1. Radiology Division, Istituto Nazionale Tumori IRCCS Fondazione Pascale – IRCCS di Napoli, 80131, Naples, Italy

    Vincenza Granata, Roberta Fusco, Sergio Venanzio Setola, Carmine Picone, Paolo Vallone & Antonella Petrillo

  2. Hepatobiliary Surgical Oncology Division, Istituto Nazionale Tumori IRCCS Fondazione Pascale – IRCCS di Napoli, 80131, Naples, Italy

    Andrea Belli, Paola Incollingo, Vittorio Albino & Francesco Izzo

  3. Pathology Diagnostic Division, Istituto Nazionale Tumori IRCCS Fondazione Pascale – IRCCS di Napoli, 80131, Naples, Italy

    Fabiana Tatangelo

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  1. Vincenza Granata
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  2. Roberta Fusco
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Correspondence to Roberta Fusco.

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Granata, V., Fusco, R., Setola, S.V. et al. Microvascular invasion and grading in hepatocellular carcinoma: correlation with major and ancillary features according to LIRADS. Abdom Radiol 44, 2788–2800 (2019). https://doi.org/10.1007/s00261-019-02056-6

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  • DOI: https://doi.org/10.1007/s00261-019-02056-6

Keywords

  • Hepatocellular carcinoma
  • Microvascular invasion
  • Histological grading
  • Multidetector computed tomography
  • Magnetic resonance imaging