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Transcatheter arterial infusion for pancreatic cancer: a 10-year National Cancer Center experience in 115 patients and literature review

  • Interventional Radiology
  • Published:
Abdominal Radiology Aims and scope Submit manuscript

Abstract

Purpose

To evaluate the efficacy and safety of transcatheter arterial infusion (TAI) for the treatment of pancreatic cancer in patients ineligible for or refractory to systemic chemotherapy.

Materials and methods

The medical records of 115 consecutive patients (mean age, 58.9 years; 71 males) with documented pancreatic cancer ineligible for or refractory to systemic chemotherapy and underwent TAI between February 2007 and January 2017 were reviewed.

Results

A total of 224 TAI sessions [mean, 1.9 (range 1–8)] were performed. Technical success rate was 100%. Disease control (i.e., complete response, partial response, and stable disease) was achieved in 72 (62.6%) patients. The median progression-free survival and median overall survival were 56 days and 147 days, respectively. Subgroup analysis revealed that disease control, progression-free survival, and overall survival were significantly improved in patients with an Eastern Cooperative Oncology Group score of ≤ 1 compared with those in patients with an Eastern Cooperative Oncology Group score of 2 (all p < 0.001) and in patients who received > 1 sessions of TAI compared with that in patients who received only 1 session of TAI (p = 0.012, < 0.001, and = 0.002, respectively). A major complication in the form of cerebral infarction occurred in 1 (0.9%) patient 1 day after the procedure. This patient was treated with conservative therapy and recovered without permanent adverse sequelae. No other major complications were observed.

Conclusions

TAI may be effective and safe for the treatment of pancreatic cancer.

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Funding

This paper was supported by the Chinese Academy of Medical Sciences Initiative for Innovative Medicine (Grant No. 2016-I2 M-2-004 to X.L.) and Graduate Innovative Program of Peking Union Medical College (Grant No., 2017-1002-2-05 to B.Q.).

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Authors and Affiliations

  1. Department of Interventional Therapy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 17 Panjiayuan Nanli, Chaoyang District, Beijing, 100021, China

    Bin Qiu, Xiaowu Zhang, Jiaywei Tsauo, He Zhao, Tao Gong, Jingui Li & Xiao Li

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  1. Bin Qiu
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  2. Xiaowu Zhang
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  3. Jiaywei Tsauo
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  4. He Zhao
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  6. Jingui Li
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  7. Xiao Li
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Correspondence to Jiaywei Tsauo or Xiao Li.

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Qiu, B., Zhang, X., Tsauo, J. et al. Transcatheter arterial infusion for pancreatic cancer: a 10-year National Cancer Center experience in 115 patients and literature review. Abdom Radiol 44, 2801–2808 (2019). https://doi.org/10.1007/s00261-019-02022-2

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