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Appendiceal endosalpingiosis: clinical presentation and imaging appearance of a rare condition of the appendix

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Endosalpingiosis rarely affects the appendix but can be mistaken for acute appendicitis or appendiceal tumors. The medical literature regarding appendiceal endosalpingiosis is sparse; consisting of only four case reports which are primarily focused on the histopathology but provide little radiologic correlation. Endosalpingiosis is a rare condition characterized by the presence of benign fallopian tubal-like glandular epithelium derived from Mullerian ducts, usually affecting the serosal surfaces of the pelvis and peritoneum. It is histologically differentiated from endometriosis as endosalpingiosis lacks endometrial stroma. Endosalpingiosis tends to affect older women and has been associated with ovarian serous tumors of low malignant potential. After a retrospective review of a pathology database, we present pathologically proven cases of appendiceal endosalpingiosis with correlative imaging. We discuss the clinical presentation, illustrate the CT and MRI appearance, histologic characteristics, and review the current medical literature of appendiceal endosalpingiosis.

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Correspondence to Todd R. Williams.

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No grants or funding was involved in this project.

Conflict of interest

All authors (Drs. Tudor, Williams, Myers and Umar) declare no conflicts of interest.

Ethical approval

The study is a retrospective review of the medical record and is compliant with Henry Ford. Hospital’s Institutional Review Board guidelines (IRB# 12225) and was performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. For this type of study (retrospective review) formal consent is not required.

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This article does not contain studies with human or animal participants performed by any of the authors.

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Tudor, J., Williams, T.R., Myers, D.T. et al. Appendiceal endosalpingiosis: clinical presentation and imaging appearance of a rare condition of the appendix. Abdom Radiol 44, 3246–3251 (2019).

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