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Diurnal variation of renal resistive index over 24-hour period in hypertensive patients and healthy controls

Abdominal Radiology volume 44, pages 1010–1018 (2019)Cite this article

Abstract

Purpose

There are no data in the literature to our knowledge related to changes in renal resistive index (RRI) values over 24-h period and the importance of detecting these changes in patients who have hypertension (HT). In this study, we aimed to investigate the variation of RRI values over 24-h period and its usability in hypertensive patients.

Methods

A total of 118 subjects (80 with HT and 38 healthy controls) were included in the study. Morning, midday, evening, and midnight RRI, renal pulsatility index, and accelerated time were measured by Doppler ultrasonography (US). B-mode US and elastograpic assessment were performed only in the morning.

Results

Temporal RRI varied significantly (p < 0.001). The highest and lowest levels were found in the morning and evening, respectively. All temporal RRI levels were significantly higher in patients with HT (both p < 0.001). The absolute and relative increases in RRI (ΔRRI) levels were similar in two groups. All temporal RRI measurements positively correlated with the patient age, pulse pressure, renal cortical thickness, and cortical stiffness. However, absolute-ΔRRI and relative-ΔRRI positively correlated with the age. Absolute-ΔRRI positively correlated with the pulse pressure and cortical stiffness, and no correlation was observed between relative-ΔRRI and these variables. Of the four temporal measurements, morning RRI were found to be independently associated with cortical stiffness (p < 0.001).

Conclusions

RRI measurements varied over 24-h period in patients with HT and/or healthy controls. Morning RRI was significantly higher than other day time, and it is also related to renal cortical stiffness.

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Affiliations

  1. Department of Radiology, University of Health Sciences-Adana Health Practice and Research Center, Dr. Mithat Özsan Bulvarı Kışla Mah. 4522 Sok. No: 1 Yüreğir, Adana, Turkey

    Ayse Selcan Koc & Feride Fatma Gorgulu

  2. Department of Internal Medicine, University of Health Sciences-Adana Health Practice and Research Center, Adana, Turkey

    Derya Demirtas & Hilmi Erdem Sumbul

Authors
  1. Ayse Selcan Koc
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  2. Derya Demirtas
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  3. Feride Fatma Gorgulu
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  4. Hilmi Erdem Sumbul
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Corresponding author

Correspondence to Ayse Selcan Koc.

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No funding was received for this study.

Conflict of interest

There is no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the Ethical Standards of the Institutional and/or National Research Committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Koc, A.S., Demirtas, D., Gorgulu, F.F. et al. Diurnal variation of renal resistive index over 24-hour period in hypertensive patients and healthy controls. Abdom Radiol 44, 1010–1018 (2019). https://doi.org/10.1007/s00261-018-1798-3

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  • DOI: https://doi.org/10.1007/s00261-018-1798-3

Keywords

  • Hypertension
  • Renal resistive index
  • Variation