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Abdominal Radiology

, Volume 44, Issue 1, pp 85–94 | Cite as

Computed tomographic perfusion with 160-mm coverage: comparative analysis of hepatocellular carcinoma treated by two transarterial chemoembolization courses relative to magnetic resonance imaging findings

  • Matthieu BayleEmail author
  • Isabelle Clerc-Urmès
  • Ahmet Ayav
  • Jean-Pierre Bronowicki
  • Isabelle Petit
  • Xavier Orry
  • Valérie Laurent
Article
  • 112 Downloads

Abstract

Purpose

The aim of this study was to assess hepatocellular carcinoma (HCC) response with CT perfusion parameters before and after two transarterial chemo embolization (TACE) courses compared with MRI, and to search for predictive factors of response.

Methods

37 lesions (19 patients) were included between October 2015 and September 2017, based on the Barcelona Clinic Liver Cancer guidelines. CT perfusion with 160-mm coverage and MRI were performed before and after the first TACE course, and after the second TACE course. Quantitative perfusion parameters were compared to the response assessed with MRI using mRECIST criteria, defining response groups: complete response (CR), partial response (PR), no response (NR), response (including CR and PR), no complete response (NCR, including PR and NR).

Results

Pre-TACE blood flow (BF) and hepatic arterial blood flow (HABF) were significantly higher in lesions with post-TACE 1 CR than in those with NCR (BF: 118.8 vs. 76.3 mL/100 g/min, p = 0.0231; HABF: 76 vs. 44.2 mL/100 g/min, p = 0.0112). Pre-TACE time to peak (TTP) and mean transit time (MTT) were significantly lower in lesions with post-TACE 2 response than in those with NR (TTP: 31.5 vs. 46.1 s, p = 0.0313; MTT: 15.8 vs. 22.8 s, p = 0.0204). Post-TACE 1 and post-TACE 2 perfusion parameters did not exhibit any statistically significant differences relative to MRI response.

Conclusion

Our study did not find, after a first TACE course, perfusion parameters associated with a response to a second TACE course. However, baseline perfusion parameters analysis could lead to better therapeutic management of HCC by targeting lesions likely to respond well to TACE courses.

Keywords

Hepatocellular carcinoma Transarterial chemoembolization Perfusion imaging Computed tomography Magnetic resonance imaging 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments. For this type of study formal consent is not required.

Supplementary material

261_2018_1714_MOESM1_ESM.docx (20 kb)
Supplementary material 1 (DOCX 20 kb)

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of RadiologyCHRU Nancy, Brabois Adults HospitalVandoeuvre-lès-NancyFrance
  2. 2.Biostatistics Unit (PARC)CHRU NancyVandoeuvre-lès-NancyFrance
  3. 3.Department of HBP SurgeryCHRU Nancy, Brabois Adults HospitalVandoeuvre-lès-NancyFrance
  4. 4.Université de Lorraine, Faculté de MédecineVandoeuvre-lès-NancyFrance
  5. 5.Department of Hepato-gastroenterologyCHRU Nancy, Brabois Adults HospitalVandoeuvre-lès-NancyFrance
  6. 6.INSERM, U954Vandoeuvre-lès-NancyFrance
  7. 7.INSERM, U947, IADIVandoeuvre-lès-NancyFrance

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