High spatial resolution navigated 3D T1-weighted hepatobiliary MR cholangiography using Gd-EOB-DTPA for evaluation of biliary anatomy in living liver donors
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To determine the feasibility of high-resolution navigated three-dimensional (3D) T1-weighted hepatobiliary MR cholangiography (Nav T1 MRC) using Gd-EOB-DTPA for biliary visualization in living liver donors and to assess added value of 3D T1-weighted hepatobiliary MRCs in improving the confidence and diagnostic accuracy of biliary anatomy in complementary to T2-weighted MRCs.
Twenty-nine right liver donors underwent 3D T2 MRC, 2D T2 MRC, breath-hold T1-weighted hepatobiliary MRC (BH T1 MRC), and Nav T1 MRC. Two readers independently reviewed and compared 3D/2D MRC set, added BH T1 MRC set, and added Nav T1 MRC set for biliary diagnostic accuracy and confidence. For each MRC, biliary segments visualization and image quality were scored.
Both BH T1 MRC and Nav T1 MRC improved accuracy and specificity in biliary diagnosis when added to 3D/2D T2 MRC-alone set, though without statistical significance (R1, 82.8% to 93.1%; R2, 82.8% to 89.7%). The added Nav T1 MRC set showed the highest diagnostic confidence with both readers. Both readers scored Nav T1 MRC with the highest visualization scores for branching ducts and overall ducts.
Combining T1-weighted hepatobiliary MRCs to 3D/2D T2 MRC set improved accuracy for biliary anatomy diagnosis; time-efficient BH T1 MRC in axial and coronal planes should be considered as a key MRC sequence complementary to T2 MRCs. Given excellent biliary visualization and superior diagnostic confidence, Nav T1 MRC in selected subjects with breath-hold difficulties and inconclusive or complex biliary variations may assist in reaching a correct biliary diagnosis.
KeywordsLiver transplantation Magnetic resonance cholangiopancreatography Gadoxetate disodium
Compliance with ethical standards
No funding was received for this study.
Conflict of interest
All authors declare that they have no conflict of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent was obtained from all individual participants included in the study.
- 9.Kinner S, Steinweg V, Maderwald S, et al. (2014) Comparison of different magnetic resonance cholangiography techniques in living liver donors including Gd-EOB-DTPA enhanced T1-weighted sequences. PLoS ONE 9:e113882. https://doi.org/10.1371/journal.pone.0113882 CrossRefPubMedPubMedCentralGoogle Scholar
- 11.Lee ES, Lee JM, Yu MH, et al. (2014) High spatial resolution, respiratory-gated, t1-weighted magnetic resonance imaging of the liver and the biliary tract during the hepatobiliary phase of gadoxetic Acid-enhanced magnetic resonance imaging. J Comput Assist Tomogr 38:360–366. https://doi.org/10.1097/rct.0000000000000055 CrossRefPubMedGoogle Scholar
- 16.Kinner S, Steinweg V, Maderwald S, et al. (2014) Bile duct evaluation of potential living liver donors with Gd-EOB-DTPA enhanced MR cholangiography: single-dose, double dose or half-dose contrast enhanced imaging. Eur J Radiol 83:763–767. https://doi.org/10.1016/j.ejrad.2014.02.012 CrossRefPubMedGoogle Scholar
- 17.Lee MS, Lee JY, Kim SH, et al. (2011) Gadoxetic acid disodium-enhanced magnetic resonance imaging for biliary and vascular evaluations in preoperative living liver donors: comparison with gadobenate dimeglumine-enhanced MRI. J Magn Reson Imaging 33:149–159. https://doi.org/10.1002/jmri.22429 CrossRefPubMedGoogle Scholar
- 21.Ragab A, Lopez-Soler RI, Oto A, Testa G (2013) Correlation between 3D-MRCP and intra-operative findings in right liver donors. Hepatobiliary Surg Nutr 2:7–13. https://doi.org/10.3978/j.issn.2304-3881.2012.11.01 PubMedPubMedCentralGoogle Scholar