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Hepatocarcinogenesis and LI-RADS

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Abstract

Hepatocarcinogenesis is a multi-step process characterized by progressive cellular and molecular dedifferentiation of hepatocytes and culminating in the emergence of hepatocellular carcinoma (HCC). Knowledge of hepatocarcinogenesis is important because familiarity with the associated imaging features can lead to improved diagnosis of HCC at its early stages. The article reviews the alterations that accumulate leading to HCC result in abnormal imaging features, many of which are included in LI-RADS v2017 as major and ancillary features.

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reproduced with permission from Choi et al. Radiology 2014

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Authors and Affiliations

  1. Liver Imaging Group, Department of Radiology, University of California San Diego, 200 W. Arbor Drive #8756, San Diego, CA, 92103, USA

    Kazim H. Narsinh, Jennifer Cui, Claude B. Sirlin & Cynthia S. Santillan

  2. Division of Interventional Radiology, Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA

    Kazim H. Narsinh

  3. Department of Diagnostic Imaging, University of Ottawa, Ottawa, Canada

    Demetri Papadatos

Authors
  1. Kazim H. Narsinh
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  2. Jennifer Cui
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  3. Demetri Papadatos
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  4. Claude B. Sirlin
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  5. Cynthia S. Santillan
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Corresponding author

Correspondence to Cynthia S. Santillan.

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Funding

This study was not supported by a grant.

Conflicts of interest

Kazim Narsinh declares that he has no conflict of interest. Jennifer Cui declares that she has no conflict of interest. Demetri Papadatos declares that he has no conflict of interest. Claude Sirlin receives grant funding from Bayer, Guerbet, Siemens, General Electric, Supersonic, and Arterys. He has consulting and service agreements with Alexion, AstraZeneca, Bioclinica, BMS, Bracco, Celgene, Fibrogen, Galmed, Genentech, Genzyme, Gilead, Icon, Intercept, Isis, Janssen, NuSirt, Perspectum, Pfizer, Profil, Sanofi, Shire, Synageva, Tobira, Takeda, and Virtual Scopics. Cynthia Santillan declares that she has no conflict of interest.

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This article does not contain any studies with human participants performed by any of the authors.

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Narsinh, K.H., Cui, J., Papadatos, D. et al. Hepatocarcinogenesis and LI-RADS. Abdom Radiol 43, 158–168 (2018). https://doi.org/10.1007/s00261-017-1409-8

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  • DOI: https://doi.org/10.1007/s00261-017-1409-8

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