Genetics of pancreatic cancer and implications for therapy

  • Priya Bhosale
  • Veronica Cox
  • Silvana Faria
  • Sanaz Javadi
  • Chitra Viswanathan
  • Eugene Koay
  • Eric Tamm
Invited article
  • 108 Downloads

Abstract

Pancreatic cancer is a highly lethal disease with a dismal 5-year prognosis. Knowledge of its genetics may help in identifying new methods for patient screening, and cancer treatment. In this review, we will describe the most common mutations responsible for the genesis of pancreatic cancer and their impact on screening, patterns of disease progression, and therapy.

Keywords

Pancreatic cancer Genomics Imaging Mutations 

Notes

Acknowledgments

The University of Texas is supported in part by the National Institutes of Health through the Cancer Center Support Grant, P30CA016672.

Compliance with ethical standards

Conflict of interest

Priya Bhosale, MD, Veronica Cox, MD, Silvana Faria, MD PhD, Sanaz Javadi, MD, Chitra Viswanathan, MD, Eugene Koay, MD, Eric Tamm, MD, have no conflict of interest.

Ethical statement

This article does not contain any studies with human participants or animals performed by any authors. IRB was waived as it is a review article.

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© Springer Science+Business Media, LLC, part of Springer Nature 2017

Authors and Affiliations

  • Priya Bhosale
    • 1
  • Veronica Cox
    • 1
  • Silvana Faria
    • 1
  • Sanaz Javadi
    • 1
  • Chitra Viswanathan
    • 1
  • Eugene Koay
    • 2
  • Eric Tamm
    • 1
  1. 1.Department of Diagnostic Radiology, Unit 38The University of Texas MD Anderson Cancer CenterHoustonUSA
  2. 2.Department of Radiation OncologyThe University of Texas MD Anderson Cancer CenterHoustonUSA

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