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Assessment of iodine uptake by pancreatic cancer following chemotherapy using dual-energy CT

  • Pictorial essay
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Abstract

Pancreatic cancer remains a major health problem, and only less than 20% of patients have resectable disease at the time of initial diagnosis. Systemic chemotherapy is often used in the patients with borderline resectable, locally advanced unresectable disease and metastatic disease. CT is often used to assess for therapeutic response; however, conventional imaging including CT may not correctly reflect treatment response after chemotherapy. Dual-energy (DE) CT can acquire datasets at two different photon spectra in a single CT acquisition, and permits separating materials and extract iodine by applying a material decomposition algorithm. Quantitative iodine mapping may have an added value over conventional CT imaging for monitoring the treatment effects in patients with pancreatic cancer and potentially serve as a unique biomarker for treatment response. In this pictorial essay, we will review the technique for iodine quantification of pancreatic cancer by DECT and discuss our observations of iodine quantification at baseline and after systemic chemotherapy with conventional cytotoxic agents, and illustrate example cases.

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Authors and Affiliations

  1. The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD, USA

    Satomi Kawamoto & Elliot K. Fishman

  2. JHOC 3140E, 601 N. Caroline Street, Baltimore, MD, 21287, USA

    Satomi Kawamoto

  3. The Russell H. Morgan Department of Radiology and Radiological Science, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD, USA

    Matthew. K. Fuld

  4. Siemens Medical Solutions USA, Inc, Malvern, PA, USA

    Matthew. K. Fuld

  5. Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD, USA

    Daniel Laheru & Peng Huang

  6. Department of Biostatistics, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD, USA

    Peng Huang

Authors
  1. Satomi Kawamoto
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  2. Matthew. K. Fuld
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  3. Daniel Laheru
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  4. Peng Huang
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  5. Elliot K. Fishman
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Corresponding author

Correspondence to Satomi Kawamoto.

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Funding

This study was funded by Siemens Medical Solutions, Inc. (grant number JHU-2012-CT-118-01).

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Kawamoto, S., Fuld, M.K., Laheru, D. et al. Assessment of iodine uptake by pancreatic cancer following chemotherapy using dual-energy CT. Abdom Radiol 43, 445–456 (2018). https://doi.org/10.1007/s00261-017-1338-6

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  • DOI: https://doi.org/10.1007/s00261-017-1338-6

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