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Quantitative assessment of the degree of differentiation in colon cancer with dual-energy spectral CT

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Abstract

Objective

To evaluate dual-energy spectral CT imaging in evaluating the degree of differentiation in colon cancer.

Methods

Forty-seven colon cancer patients underwent spectral CT during arterial phase (AP) and portal venous phase (PP), and were characterized pathologically differentiated to well-differentiated (A, n = 18) and poorly differentiated or undifferentiated carcinoma group (B, n = 29). Lesion iodine concentration (IC) was measured and normalized to that of aorta (NIC). CT numbers were measured and the slope (λ HU) of the spectral HU curve was calculated. These parameters were statistically compared between the two groups. ROC curves were used to evaluate their diagnostic efficacies.

Results

There were significant differences in IC (1.01 ± 0.20 vs. 1.59 ± 0.57 mg/ml), NIC (0.12 ± 0.03 vs. 0.19 ± 0.09), λ HU (1.41 ± 0.29 vs. 2.03 ± 0.85), and CT number at 70 keV (48.61 ± 9.03HU vs. 63.97 ± 15.86HU) between groups A and B in AP (p < 0.05), but no difference in PP. Using IC = 1.13 mg/ml in AP as the threshold, one obtained a sensitivity of 81.8% and a specificity of 71.4% for differentiating well-differentiated from poorly differentiated or undifferentiated carcinoma. These values were statistically higher than those (64.7% and 62.3%) using CT number at 70 keV.

Conclusion

Spectral CT imaging parameters (IC, NIC, and λ HU) in AP provide improved accuracy for evaluating the degrees of differentiation in colon cancer than CT number at 70 keV.

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Acknowledgments

The authors would like to thank Dr Jianying Li and Dr Yun Shen for excellent technical support and for critically reviewing the manuscript.

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Authors and Affiliations

  1. Department of Radiology, Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, 712000, China

    Yang Chuang-bo, He Tai-ping, Duan Hai-feng, Jia Yong-jun, Zhang Xi-rong, Ma Guang-ming, Ren Chenglong & Yu Yong

  2. Department of Pathology, Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, 712000, China

    Wang Jun

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  1. Yang Chuang-bo
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  2. He Tai-ping
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  3. Duan Hai-feng
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  4. Jia Yong-jun
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  6. Ma Guang-ming
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  7. Ren Chenglong
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  8. Wang Jun
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  9. Yu Yong
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Corresponding author

Correspondence to Yu Yong.

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No funding was received for this study.

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The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Chuang-bo, Y., Tai-ping, H., Hai-feng, D. et al. Quantitative assessment of the degree of differentiation in colon cancer with dual-energy spectral CT. Abdom Radiol 42, 2591–2596 (2017). https://doi.org/10.1007/s00261-017-1176-6

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  • DOI: https://doi.org/10.1007/s00261-017-1176-6

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