Abdominal Radiology

, Volume 42, Issue 6, pp 1695–1704 | Cite as

CT-based radiomics signature: a potential biomarker for preoperative prediction of early recurrence in hepatocellular carcinoma

  • Ying Zhou
  • Lan He
  • Yanqi Huang
  • Shuting Chen
  • Penqi Wu
  • Weitao Ye
  • Zaiyi LiuEmail author
  • Changhong LiangEmail author



To develop a CT-based radiomics signature and assess its ability for preoperatively predicting the early recurrence (≤1 year) of hepatocellular carcinoma (HCC).


A total of 215 HCC patients who underwent partial hepatectomy were enrolled in this retrospective study, and all the patients were followed up at least within 1 year. Radiomics features were extracted from arterial- and portal venous-phase CT images, and a radiomics signature was built by the least absolute shrinkage and selection operator (LASSO) logistic regression model. Preoperative clinical factors associated with early recurrence were evaluated. A radiomics signature, a clinical model, and a combined model were built, and the area under the curve (AUC) of operating characteristics (ROC) was used to explore their performance to discriminate early recurrence.


Twenty-one radiomics features were chosen from 300 candidate features to build a radiomics signature that was significantly associated with early recurrence (P < 0.001), and they presented good performance in the discrimination of early recurrence alone with an AUC of 0.817 (95% CI: 0.758–0.866), sensitivity of 0.794, and specificity of 0.699. The AUCs of the clinical and combined models were 0.781 (95% CI: 0.719–0.834) and 0.836 (95% CI: 0.779–0.883), respectively, with the sensitivity being 0.784 and 0.824, and the specificity being 0.619 and 0.708, respectively. Adding a radiomics signature into conventional clinical variables can significantly improve the accuracy of the preoperative model in predicting early recurrence (P = 0.01).


The radiomics signature was a significant predictor for early recurrence in HCC. Incorporating radiomics signature into conventional clinical factors performed better for preoperative estimation of early recurrence than with clinical variables alone.


Hepatocellular carcinoma Computed tomography Radiomics signature Predictor Recurrence 



We deeply appreciated the Medical Record Management Center for its close cooperation in data collection, sorting, verification, and database creation.

Compliance with ethical standards


This study was funded by the National Natural Scientific Foundation of China (Grant Numbers: 81271569, 81271654 and U1301258).

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study, formal consent is not required.

Informed consent

Statement of informed consent was not applicable since the article does not contain any patient data.

Supplementary material

261_2017_1072_MOESM1_ESM.docx (31 kb)
Supplementary material 1 (DOCX 30 kb)


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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Ying Zhou
    • 1
    • 2
    • 3
  • Lan He
    • 4
  • Yanqi Huang
    • 2
  • Shuting Chen
    • 1
    • 2
  • Penqi Wu
    • 1
    • 2
  • Weitao Ye
    • 2
  • Zaiyi Liu
    • 1
    • 2
    Email author
  • Changhong Liang
    • 1
    • 2
    Email author
  1. 1.Graduate CollegeSouthern Medical UniversityGuangzhouChina
  2. 2.Department of Radiology, Guangdong General HospitalGuangdong Academy of Medical SciencesGuangzhouChina
  3. 3.Department of RadiologyMianyang Central HospitalMianyangChina
  4. 4.School of MedicineSouth China University of TechnologyGuangzhouChina

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