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Radiographic capsule-based system for non-cathartic colorectal cancer screening


Many patients are reluctant to undergo optical colonoscopy for colorectal cancer screening. The Check-Cap colon imaging system is a non-invasive test that comprises an ingestible imaging capsule that emits and detects ultra-low-dose radiation. The capsule generates a 3D reconstruction of the colonic lumen for detection of polyps and cancer. Preliminary preclinical and clinical testing has demonstrated safety and feasibility. Mean radiation dose is estimated at 0.04 mSv. In conclusion, we describe a novel capsule-based, patient-friendly colorectal test that holds potential for non-invasive screening.

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Corresponding author

Correspondence to Perry J. Pickhardt.

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No funding was received for this study.

Conflict of interest

Drs. Kimchy, Lifshitz, and Lewkowitz are employed by Check-Cap; Drs. Pickhardt and Arber are advisors to Check-Cap; Dr. Pickhardt is also co-founder of VirtuoCTC, and shareholder in Elucent, SHINE, and Cellectar Biosciences. The other authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Kimchy, Y., Lifshitz, R., Lewkowitz, S. et al. Radiographic capsule-based system for non-cathartic colorectal cancer screening. Abdom Radiol 42, 1291–1297 (2017).

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  • Colorectal cancer
  • Colorectal polyps
  • Screening
  • Colon capsule