Abdominal Radiology

, Volume 42, Issue 5, pp 1393–1399 | Cite as

Evaluation of upper abdominal organs with DWI in patients with familial Mediterranean fever

  • Eda AlbayrakEmail author
  • Safak Sahin



To investigate the diagnostic efficiency of diffusion-weighted magnetic resonance imaging (DWI) for the evaluation of functional changes that can occur in upper abdominal organs in patients with familial Mediterranean fever (FMF).


The study included 50 controls, 45 patients with FMF, and 14 patients with FMF who had accompanying proteinuria. Measurement of apparent diffusion coefficient (ADC) was performed using DWI sections obtained from liver, spleen, kidney, and pancreas parenchyma with 1.5T MRI using b = 500 and b = 1000 s/mm2 values both in patients and control groups. Mean ADC values were compared between patient and control groups.


Renal ADC values were lower in the patient groups compared to the control group. Additionally, renal ADC values showed further decrease in the patient group in the presence of accompanying proteinuria, when compared to the FMF group without proteinuria (p < 0.001). Based on the ROC analysis, calculated cutoff values for the determination of FMF and FMF accompanied by proteinuria were 2.26 × 10−3 and 2.04 × 10−3 mm2/s, respectively. Liver, spleen, and pancreas ADC values did not show remarkable change between patient and control groups.


Present findings indicate that the presence of FMF and its clinical progression expressed by proteinuria can be differentially determined with renal DWI.


Familial Mediterranean fever Diffusion magnetic resonance imaging Apparent diffusion coefficient 


Compliance with ethical standards


No funding was received for this study.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in the studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.Department of Radiology, Medical FacultyGaziosmanpasa UniversityTokatTurkey
  2. 2.Department of İnternal Medicine, Medical FacultyGaziosmanpasa UniversityTokatTurkey

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