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Evaluation of upper abdominal organs with DWI in patients with familial Mediterranean fever

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Abstract

Purpose

To investigate the diagnostic efficiency of diffusion-weighted magnetic resonance imaging (DWI) for the evaluation of functional changes that can occur in upper abdominal organs in patients with familial Mediterranean fever (FMF).

Methods

The study included 50 controls, 45 patients with FMF, and 14 patients with FMF who had accompanying proteinuria. Measurement of apparent diffusion coefficient (ADC) was performed using DWI sections obtained from liver, spleen, kidney, and pancreas parenchyma with 1.5T MRI using b = 500 and b = 1000 s/mm2 values both in patients and control groups. Mean ADC values were compared between patient and control groups.

Results

Renal ADC values were lower in the patient groups compared to the control group. Additionally, renal ADC values showed further decrease in the patient group in the presence of accompanying proteinuria, when compared to the FMF group without proteinuria (p < 0.001). Based on the ROC analysis, calculated cutoff values for the determination of FMF and FMF accompanied by proteinuria were 2.26 × 10−3 and 2.04 × 10−3 mm2/s, respectively. Liver, spleen, and pancreas ADC values did not show remarkable change between patient and control groups.

Conclusion

Present findings indicate that the presence of FMF and its clinical progression expressed by proteinuria can be differentially determined with renal DWI.

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Authors and Affiliations

  1. Department of Radiology, Medical Faculty, Gaziosmanpasa University, 60100, Tokat, Turkey

    Eda Albayrak

  2. Department of İnternal Medicine, Medical Faculty, Gaziosmanpasa University, Tokat, Turkey

    Safak Sahin

Authors
  1. Eda Albayrak
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  2. Safak Sahin
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Corresponding author

Correspondence to Eda Albayrak.

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Funding

No funding was received for this study.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in the studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Albayrak, E., Sahin, S. Evaluation of upper abdominal organs with DWI in patients with familial Mediterranean fever. Abdom Radiol 42, 1393–1399 (2017). https://doi.org/10.1007/s00261-016-1005-3

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