Skip to main content
SpringerLink
Log in

Clear cell renal cell carcinoma: identifying the gain of chromosome 20 on multiphasic MDCT

  • Published:
Abdominal Radiology Aims and scope Submit manuscript

Abstract

Purpose

To investigate whether multiphasic multidetector computed tomography (MDCT) enhancement can help identify the gain of chromosome 20 in clear cell renal cell carcinomas (RCCs), a rare prognostically significant cytogenetic abnormality.

Methods

With the Institutional Review Board approval, we queried our institution’s pathology database to derive a cohort of 52 cases of clear cell RCC with preoperative four-phase renal mass protocol MDCT and karyotypes of the resected specimens during a 10-year period. Each lesion was evaluated for absolute and relative (compared to contralateral normal renal cortex) attenuations in each phase. Relative attenuation was calculated as [(lesion attenuation − cortex attenuation)/cortex attenuation] × 100. The absolute and relative attenuations were compared using t-tests.

Results

Clear cell RCCs with the gain of 20 had significantly less nephrographic and excretory phase enhancement than clear cell RCCs without the gain of 20 (86.4 HU vs. 111.4 HU, p = 0.007; 70.0 HU vs. 89.4 HU, p = 0.003; respectively). Additionally, the relative nephrographic and excretory phase attenuations of clear cell RCCs with the gain of 20 were significantly less than that of clear cell RCCs without the gain of 20 (−52.7 vs. −34.7, p = 0.002; −44.9 vs. −31.1, p = 0.005; respectively).

Conclusion

Multiphasic MDCT enhancement may assist in identifying the gain of chromosome 20 in clear cell RCCs, if validated in a large prospective trial.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Ljungberg B, Campbell SC, Cho HY, et al. (2011) The epidemiology of renal cell carcinoma. Eur Urol 60:615–621

    Article  PubMed  Google Scholar 

  2. Cohen HT, McGovern FJ (2005) Renal-cell carcinoma. N Engl J Med 353:2477–2490

    Article  CAS  PubMed  Google Scholar 

  3. Klatte T, Rao PN, de Martino M, et al. (2009) Cytogenetic profile predicts prognosis of patients with clear cell renal cell carcinoma. J Clin Oncol 27:746–753

    Article  PubMed  Google Scholar 

  4. Gunawan B, Huber W, Holtrup M, et al. (2001) Prognostic impacts of cytogenetic findings in clear cell renal cell carcinoma: gain of 5q31-qter predicts a distinct clinical phenotype with favorable prognosis. Cancer Res 61:7731–7738

    CAS  PubMed  Google Scholar 

  5. Elfving P, Mandahl N, Lundgren R, et al. (1997) Prognostic implications of cytogenetic findings in kidney cancer. Br J Urol 80:698–706

    Article  CAS  PubMed  Google Scholar 

  6. Young JR, Margolis D, Sauk S, et al. (2013) Clear cell renal cell carcinoma: discrimination from other renal cell carcinoma subtypes and oncocytoma at multiphasic multidetector CT. Radiology 267:444–453

    Article  PubMed  Google Scholar 

  7. Lee-Felker SA, Felker ER, Tan N, et al. (2014) Qualitative and quantitative MDCT features for differentiating clear cell renal cell carcinoma from other solid renal cortical masses. AJR Am J Roentgenol 203:W516–W524

    Article  PubMed  Google Scholar 

  8. Zhang J, Lefkowitz RA, Ishill NM, et al. (2007) Solid renal cortical tumors: differentiation with CT. Radiology 244:494–504

    Article  PubMed  Google Scholar 

  9. Sheir KZ, El-Azab M, Mosbah A, El-Baz M, Shaaban AA (2005) Differentiation of renal cell carcinoma subtypes by multislice computerized tomography. J Urol 174:451–455

    Article  PubMed  Google Scholar 

  10. Kim JK, Kim TK, Ahn HJ, et al. (2002) Differentiation of subtypes of renal cell carcinoma on helical CT scans. AJR Am J Roentgenol 178:1499–1506

    Article  PubMed  Google Scholar 

  11. Jinzaki M, Tanimoto A, Mukai M, et al. (2000) Double-phase helical CT of small renal parenchymal neoplasms: correlation with pathologic findings and tumor angiogenesis. J Comput Assist Tomogr 24:835–842

    Article  CAS  PubMed  Google Scholar 

  12. Ruppert-Kohlmayr AJ, Uggowitzer M, Meissnitzer T, Ruppert G (2004) Differentiation of renal clear cell carcinoma and renal papillary carcinoma using quantitative CT enhancement parameters. AJR Am J Roentgenol 183:1387–1391

    Article  PubMed  Google Scholar 

  13. Young JR, Margolis D, Sauk S, et al. (2014) Clear cell renal cell carcinoma: multiphasic MDCT enhancement can predict the loss of chromosome 8p. Abdom Imaging 39:543–549

    Article  PubMed  Google Scholar 

  14. Sauk SC, Hsu MS, Margolis DJ, et al. (2011) Clear cell renal cell carcinoma: multiphasic multidetector CT imaging features help predict genetic karyotypes. Radiology 261:854–862

    Article  PubMed  Google Scholar 

  15. Romain C, Paul P, Kim KW, et al. (2014) Targeting aurora kinase-A downregulates cell proliferation and angiogenesis in neuroblastoma. J Pediatr Surg 49:159–165

    Article  PubMed  Google Scholar 

  16. Dar A, Belkhiri A, El-Rifai W (2009) The aurora kinase A regulates GSK-3beta in gastric cancer cells. Oncogene 28:866–887

    Article  CAS  PubMed  Google Scholar 

  17. Sen S, Zhou H, White RA (1997) A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines. Oncogene 14:2195–2200

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Department of Radiology, David Geffen School of Medicine at UCLA, Ronald Reagan-UCLA Medical Center, 757 Westwood Plaza, Suite 1638, Los Angeles, CA, 90095-7437, USA

    Jonathan R. Young, Jocelyn A. Young, Daniel J.A. Margolis, Steven Sauk, James Sayre & Steven S. Raman

  2. The Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA

    Allan J. Pantuck

Authors
  1. Jonathan R. Young
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jocelyn A. Young
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Daniel J.A. Margolis
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Steven Sauk
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Allan J. Pantuck
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. James Sayre
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Steven S. Raman
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jonathan R. Young.

Ethics declarations

Conflict of interest

Jonathan R. Young, MD, Jocelyn A. Young, MD, Daniel J.A. Margolis, MD, Steven Sauk, MD, Allan J. Pantuck, MD, James Sayre, PhD, and Steven S. Raman, MD declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

The Institutional Review Board waived the requirement of informed consent for this study.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Young, J.R., Young, J.A., Margolis, D.J. et al. Clear cell renal cell carcinoma: identifying the gain of chromosome 20 on multiphasic MDCT. Abdom Radiol 41, 2175–2181 (2016). https://doi.org/10.1007/s00261-016-0813-9

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00261-016-0813-9

Keywords

Search

Navigation