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Effect of steatosis on liver signal and enhancement on multiphasic contrast-enhanced magnetic resonance imaging

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Abdominal Radiology Aims and scope

Abstract

Purpose

To investigate the effect of steatosis on liver signal and enhancement in multiphasic contrast-enhanced (MCE) MRI.

Materials and methods

In this IRB-approved, HIPAA-compliant, retrospective, observational study, 1217 MCE abdominal MRIs performed during 2014 at a single institution were reviewed. Of these, 1085 were excluded, due to potential factors other than steatosis that may affect liver signal intensity and/or enhancement. In the remaining 132, liver fat fraction (FF) was calculated from the in- and opposed-phase 2D T1-weighted images. Liver signal intensity, absolute enhancement, and relative enhancement on fat-suppressed (Dixon method) 3D T1-weighted images before and after injection of gadobutrol (arterial, portal venous, and equilibrium phases) were plotted against co-localized FF values and the linear trend was evaluated by Pearson correlation coefficient (r). P values <0.05 were considered statistically significant.

Results

Liver signal intensity negatively correlated with FF for all phases (r = −0.388 to −0.544, p < 0.001). Absolute enhancement negatively correlated with FF for the portal venous and equilibrium phases (r = −0.286 and −0.289, respectively, p < 0.001), but not for the arterial phase (r = −0.042, p = 0.632). Relative enhancement did not significantly correlate with FF for any phase (p ≥ 0.125).

Conclusion

Steatosis reduces liver signal intensity in MCE MRI. This effect of steatosis was reduced in calculated absolute enhancement and eliminated in calculated relative enhancement.

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Authors and Affiliations

  1. Department of Radiology, University of Texas Southwestern Medical Center, 2201 Inwood Road, NE2.210B, Dallas, TX, 75390-9085, USA

    Ali Pirasteh, Haley R. Clark, Endel A. Sorra II, Ivan Pedrosa & Takeshi Yokoo

  2. Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 2201 Inwood Road, NE2.210B, Dallas, TX, 75390-9085, USA

    Ivan Pedrosa & Takeshi Yokoo

Authors
  1. Ali Pirasteh
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  2. Haley R. Clark
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  3. Endel A. Sorra II
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  4. Ivan Pedrosa
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  5. Takeshi Yokoo
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Correspondence to Takeshi Yokoo.

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Pirasteh, A., Clark, H.R., Sorra, E.A. et al. Effect of steatosis on liver signal and enhancement on multiphasic contrast-enhanced magnetic resonance imaging. Abdom Radiol 41, 1744–1750 (2016). https://doi.org/10.1007/s00261-016-0736-5

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  • DOI: https://doi.org/10.1007/s00261-016-0736-5

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