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MR findings of Lynch syndrome-related uterine endometrial carcinoma: a case report

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Abstract

A 41-year-old woman presented with atypical genital bleeding. Magnetic resonance imaging demonstrated a polypoid mass from the lower uterine segment to cervical canal, approximately 32 mm in size. Additionally, a thickened sigmoid colon wall showing a markedly high signal intensity on diffusion-weighted imaging was observed. Barium enema and colonoscopy revealed a type I sigmoid colon cancer. Since this patient was relatively young and had multiple relatives with colon cancer, Lynch syndrome was suspected and proved by an immunohistochemical survey. Uterine endometrial carcinoma related to Lynch syndrome tends to occur in the lower uterine segment. Radiologists should be aware of this syndrome so that the correct diagnosis can be suggested in the imaging report.

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References

  1. Umar A, Boland CR, Terdiman JP, et al. (2004) Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. J Natl Cancer Inst 96(4):261–268

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Tafe LJ, Riggs ER, Tsongalis GJ (2014) Lynch syndrome presenting as endometrial cancer. Clin Chem 60(1):111–121. doi:10.1373/clinchem.2013.206888

    Article  CAS  PubMed  Google Scholar 

  3. Hampel H, Panescu J, Lockman J, et al. (2007) Comment on: screening for Lynch syndrome (hereditary nonpolyposis colorectal cancer) among endometrial cancer patients. Cancer Res 67(19):9603. doi:10.1158/0008-5472.CAN-07-2308

    Article  CAS  PubMed  Google Scholar 

  4. Hampel H, Frankel W, Panescu J, et al. (2006) Screening for Lynch syndrome (hereditary nonpolyposis colorectal cancer) among endometrial cancer patients. Cancer Res 66(15):7810–7817. doi:10.1158/0008-5472.CAN-06-1114

    Article  CAS  PubMed  Google Scholar 

  5. Meyer LA, Broaddus RR, Lu KH (2009) Endometrial cancer and Lynch syndrome: clinical and pathologic considerations. Cancer Control 16(1):14–22

    PubMed  PubMed Central  Google Scholar 

  6. Lu KH, Broaddus RR (2005) Gynecologic cancers in Lynch syndrome/HNPCC. Fam Cancer 4(3):249–254. doi:10.1007/s10689-005-1838-3

    Article  PubMed  Google Scholar 

  7. Wang Y, Wang Y, Li J, et al. (2013) Lynch syndrome related endometrial cancer: clinical significance beyond the endometrium. J Hematol Oncol 6:22. doi:10.1186/1756-8722-6-22

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Lu KH, Dinh M, Kohlmann W, et al. (2005) Gynecologic cancer as a “sentinel cancer” for women with hereditary nonpolyposis colorectal cancer syndrome. Obstet Gynecol 105(3):569–574. doi:10.1097/01.AOG.0000154885.44002.ae

    Article  PubMed  Google Scholar 

  9. Broaddus RR, Lynch HT, Chen LM, et al. (2006) Pathologic features of endometrial carcinoma associated with HNPCC: a comparison with sporadic endometrial carcinoma. Cancer 106(1):87–94. doi:10.1002/cncr.21560

    Article  CAS  PubMed  Google Scholar 

  10. Westin SN, Lacour RA, Urbauer DL, et al. (2008) Carcinoma of the lower uterine segment: a newly described association with Lynch syndrome. J Clin Oncol 26(36):5965–5971. doi:10.1200/JCO.2008.18.6296

    Article  PubMed  PubMed Central  Google Scholar 

  11. Lu KH, Schorge JO, Rodabaugh KJ, et al. (2007) Prospective determination of prevalence of lynch syndrome in young women with endometrial cancer. J Clin Oncol 25(33):5158–5164. doi:10.1200/JCO.2007.10.8597

    Article  CAS  PubMed  Google Scholar 

  12. Mills AM, Liou S, Ford JM, et al. (2014) Lynch syndrome screening should be considered for all patients with newly diagnosed endometrial cancer. Am J Surg Pathol 38(11):1501–1509. doi:10.1097/PAS.0000000000000321

    Article  PubMed  PubMed Central  Google Scholar 

  13. Resnick KE, Hampel H, Fishel R, Cohn DE (2009) Current and emerging trends in Lynch syndrome identification in women with endometrial cancer. Gynecol Oncol 114(1):128–134. doi:10.1016/j.ygyno.2009.03.003

    Article  PubMed  PubMed Central  Google Scholar 

  14. Brown GJ, St John DJ, Macrae FA, Aittomaki K (2001) Cancer risk in young women at risk of hereditary nonpolyposis colorectal cancer: implications for gynecologic surveillance. Gynecol Oncol 80(3):346–349. doi:10.1006/gyno.2000.6065

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Radiology, Nara Medical University, 850 Shijo-cho, Kashihara, Nara, 634-8522, Japan

    Kiyoyuki Minamiguchi, Junko Takahama, Nagaaki Marugami, Aki Marugami, Masayo Haga, Takahiro Itoh & Kimihiko Kichikawa

  2. Department of Radiology, Heisei Memorial Hospital, 827 Shijo-cho, Kashihara, Nara, 634-0813, Japan

    Megumi Takewa

  3. Department of Diagnostic Pathology, Nara Medical University, 850 Shijo-cho, Kashihara, Nara, 634-8522, Japan

    Tomoko Uchiyama

Authors
  1. Kiyoyuki Minamiguchi
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  2. Junko Takahama
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  9. Tomoko Uchiyama
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Correspondence to Kiyoyuki Minamiguchi.

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This article does not contain any studies with human participants or animals performed by any of the authors.

Conflict of Interest

Kiyoyuki Minamiguchi declares that he has no conflict of interest. Junko Takahama declares that she has no conflict of interest. Nagaaki Marugami declares that he has no conflict of interest. Aki Marugami declares that she has no conflict of interest. Masayo Haga declares that she has no conflict of interest. Megumi Takewa declares that she has no conflict of interest. Takahiro Itoh declares that he has no conflict of interest. Kimihiko Kichikawa declares that he has no conflict of interest. Tomoko Uchiyama declares that she has no conflict of interest.

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Minamiguchi, K., Takahama, J., Marugami, N. et al. MR findings of Lynch syndrome-related uterine endometrial carcinoma: a case report. Abdom Radiol 41, 1703–1706 (2016). https://doi.org/10.1007/s00261-016-0721-z

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  • DOI: https://doi.org/10.1007/s00261-016-0721-z

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