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Diagnostic value of strain elastography for differentiation between renal cell carcinoma and transitional cell carcinoma of kidney

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Abstract

Purpose

The objective of our study was to prospectively evaluate the diagnostic performance of strain elastography for differentiation between renal cell carcinomas (RCCs) and transitional cell carcinomas (TCCs) of kidney.

Methods

A total of 99 consecutive patients who were referred to our hospital because of a newly diagnosed solid renal mass suspicious for malignancy on radiological screenings were evaluated with sonography, including strain elastography. Strain elastography was used to compare the stiffness of the renal masses and renal cortex. The ratio of strain in a renal mass and nearby renal cortex was defined as the strain index value. Mean strain index values for RCCs and TCCs were compared, and mean strain index values between histological subtypes of RCC were also compared.

Results

Although TCCs were smaller than RCCs (p < 0.001), there were no significant differences in gender distribution and mean age of the patients, and mean probe-tumor distance between RCC and TCC. The mean strain index value ±SD for TCC (5.18 ± 1.12) was significantly higher than the value for RCC (4.04 ± 0.72; p < 0.001). Mean strain index value for papillary cell carcinomas (4.09 ± 0.45) was slightly higher than that for clear cell carcinomas (3.85 ± 0.78): however, the difference was not statistically significant (p = 0.51).

Conclusions

Strain elastography can be used as a valuable imaging technique for preoperative differentiation between RCC and TCC of kidney.

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Authors and Affiliations

  1. Department of Radiology, Izmir Katip Çelebi University, School of Medicine, Izmir, Turkey

    Mehmet Fatih Inci & Volkan Cakir

  2. Department of Radiology, Kırıkkale University, School of Medicine, Kırıkkale, Turkey

    Sinan Tan

  3. Department of Radiology, Gaziosmanpasa University, School of Medicine, Tokat, Turkey

    Eda Albayrak

  4. Department of Pathology, Izmir Katip Çelebi University, School of Medicine, Izmir, Turkey

    Irfan Ocal

  5. Department of Radiology, Okmeydanı Education and Research Hospital, Istanbul, Turkey

    Fuat Ozkan

  6. Department of Radiology, Atatürk Training and Research Hospital, Izmir Katip Celebi University, Polat Caddesi, Karabaglar, Izmir, 35160, Turkey

    Mehmet Fatih Inci, Tugce Ozlem Kalayci & Sebnem Karasu

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  1. Mehmet Fatih Inci
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  2. Tugce Ozlem Kalayci
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  3. Sinan Tan
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Correspondence to Mehmet Fatih Inci.

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Conflict of interest

Mehmet Fatih Inci, Tugce Ozlem Kalayci, Sinan Tan, Eda Albayrak, Sebnem Karasu, Volkan Cakir, Irfan Ocal, and Fuat Ozkan declares that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Inci, M.F., Kalayci, T.O., Tan, S. et al. Diagnostic value of strain elastography for differentiation between renal cell carcinoma and transitional cell carcinoma of kidney. Abdom Radiol 41, 1152–1159 (2016). https://doi.org/10.1007/s00261-016-0658-2

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  • DOI: https://doi.org/10.1007/s00261-016-0658-2

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