Skip to main content
SpringerLink
Log in

Regenerative liver surgeries: the alphabet soup of emerging techniques

  • Review Paper
  • Published:
Abdominal Radiology Aims and scope Submit manuscript

Abstract

New surgical procedures taking advantage of the regenerative abilities of the liver are being introduced as potential curative therapies to these patients either to provide auxiliary support while the native liver recovers or undergoes hypertrophy. For patients with hepatocellular carcinoma outside of the Milan criteria or bilobar colorectal metastases liver transplantation is not an option. Fulminant hepatic failure can be treated but requires life-long immunosuppression. These complex surgical procedures require high quality and directed imaging.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10

Similar content being viewed by others

References

  1. Singh AK, et al. (2011) Imaging of preoperative liver transplantation in adults: what radiologists should know. Radiographics 31(4):1017–1030

    Article  PubMed  Google Scholar 

  2. Tirumani SH, et al. (2014) Update on the role of imaging in management of metastatic colorectal cancer. Radiographics 34(7):1908–1928

    Article  PubMed  Google Scholar 

  3. Bernal W, Wendon J (2013) Acute liver failure. N Engl J Med 369:2525–2534

    Article  CAS  PubMed  Google Scholar 

  4. Wendon J, Lee W (2008) Encephalopathy and cerebral edema in the setting of acute liver failure: pathogenesis and management. Neurocrit Care 9(1):97–102

    Article  CAS  PubMed  Google Scholar 

  5. Akamatsu N, Sugawara Y, Kokudo N (2013) Acute liver failure and liver transplantation. Intractable Rare Dis Res 2(3):77–87

    PubMed Central  PubMed  Google Scholar 

  6. Kato T, et al. (2006) Routine use of auxiliary partial orthotopic liver transplantation for children with fulminant hepatic failure: preliminary report. Transplant Proc 38(10):3607–3608

    Article  CAS  PubMed  Google Scholar 

  7. Gubernatis G, et al. (1991) Auxiliary partial orthotopic liver transplantation (APOLT) for fulminant hepatic failure: first successful case report. World J Surg 15(5):660–665 ((discussion 665–666))

    Article  CAS  PubMed  Google Scholar 

  8. Jaeck D, et al. (2004) A two-stage hepatectomy procedure combined with portal vein embolization to achieve curative resection for initially unresectable multiple and bilobar colorectal liver metastases. Ann Surg 240(6):1037–1049 (discussion 1049–1051)

    Article  PubMed Central  PubMed  Google Scholar 

  9. Rela M, et al. (1999) Auxiliary partial orthotopic liver transplantation for Crigler-Najjar syndrome type I. Ann Surg 229(4):565–569

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  10. Yabe S, et al. (1998) Auxiliary partial orthotopic liver transplantation from living donors: significance of portal blood flow. Transplantation 66(4):484–488

    Article  CAS  PubMed  Google Scholar 

  11. Belghiti J, et al. (2004) Auxiliary liver transplantation for acute liver failure. HPB (Oxford) 6(2):83–87

    Article  CAS  Google Scholar 

  12. Tanaka K, et al. (2004) Elevated resistive index in the hepatic artery as a predictor of fulminant hepatic failure in patients with acute viral hepatitis: a prospective study using Doppler ultrasound. Dig Dis Sci 49(5):833–842

    Article  PubMed  Google Scholar 

  13. Tucker ON, Heaton N (2005) The ‘small for size’ liver syndrome. Curr Opin Crit Care 11(2):150–155

    Article  CAS  PubMed  Google Scholar 

  14. De Gaetano AM, et al. (2000) Color Doppler sonography in the diagnosis and monitoring of arterial complications after liver transplantation. J Clin Ultrasound 28(8):373–380

    Article  PubMed  Google Scholar 

  15. Berrocal T, et al. (2006) Pediatric liver transplantation: a pictorial essay of early and late complications. Radiographics 26(4):1187–1209

    Article  PubMed  Google Scholar 

  16. Coulden RA, et al. (1990) Preliminary report: hepatic vein Doppler in the early diagnosis of acute liver transplant rejection. Lancet 336(8710):273–275

    Article  CAS  PubMed  Google Scholar 

  17. Crossin JD, Muradali D, Wilson SR (2003) US of liver transplants: normal and abnormal. Radiographics 23(5):1093–1114

    Article  PubMed  Google Scholar 

  18. Low G, et al. (2013) Imaging of vascular complications and their consequences following transplantation in the abdomen. Radiographics 33(3):633–652

    Article  PubMed  Google Scholar 

  19. Azoulay D, et al. (2001) Auxiliary partial orthotopic versus standard orthotopic whole liver transplantation for acute liver failure: a reappraisal from a single center by a case-control study. Ann Surg 234(6):723–731

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  20. Nadalin S, et al. (2014) Indications and limits for associating liver partition and portal vein ligation for staged hepatectomy (ALPPS). Lessons learned from 15 cases at a single centre. Z Gastroenterol 52(1):35–42

    Article  CAS  PubMed  Google Scholar 

  21. Adam R, et al. (2000) Two-stage hepatectomy: a planned strategy to treat irresectable liver tumors. Ann Surg 232(6):777–785

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  22. Kianmanesh R, et al. (2003) Right portal vein ligation: a new planned two-step all-surgical approach for complete resection of primary gastrointestinal tumors with multiple bilateral liver metastases. J Am Coll Surg 197(1):164–170

    Article  PubMed  Google Scholar 

  23. Wicherts DA, et al. (2011) Impact of bevacizumab on functional recovery and histology of the liver after resection of colorectal metastases. Br J Surg 98(3):399–407

    Article  CAS  PubMed  Google Scholar 

  24. Aussilhou B, et al. (2008) Right portal vein ligation is as efficient as portal vein embolization to induce hypertrophy of the left liver remnant. J Gastrointest Surg 12(2):297–303

    Article  CAS  PubMed  Google Scholar 

  25. Hamady ZZ, et al. (2004) Current techniques and results of liver resection for colorectal liver metastases. Br Med Bull 70:87–104

    Article  PubMed  Google Scholar 

  26. Machi J, Sigel B (1996) Operative ultrasound in general surgery. Am J Surg 172(1):15–20

    Article  CAS  PubMed  Google Scholar 

  27. Cucchetti A, et al. (2011) Safety of hepatic resection in overweight and obese patients with cirrhosis. Br J Surg 98(8):1147–1154

    Article  CAS  PubMed  Google Scholar 

  28. Vetelainen R, et al. (2007) Steatosis as a risk factor in liver surgery. Ann Surg 245(1):20–30

    Article  PubMed Central  PubMed  Google Scholar 

  29. Tanaka K, et al. (2015) Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS): Short-term outcome, functional changes in the future liver remnant, and tumor growth activity. Eur J Surg Oncol 41:506

    Article  CAS  PubMed  Google Scholar 

  30. Schnitzbauer AA, et al. (2012) Right portal vein ligation combined with in situ splitting induces rapid left lateral liver lobe hypertrophy enabling 2-staged extended right hepatic resection in small-for-size settings. Ann Surg 255(3):405–414

    Article  PubMed  Google Scholar 

  31. Schadde E, et al. (2014) ALPPS offers a better chance of complete resection in patients with primarily unresectable liver tumors compared with conventional-staged hepatectomies: results of a multicenter analysis. World J Surg 38(6):1510–1519

    Article  PubMed  Google Scholar 

  32. de Santibanes E, Alvarez FA, Ardiles V (2012) How to avoid postoperative liver failure: a novel method. World J Surg 36(1):125–128

    Article  PubMed  Google Scholar 

  33. Alvarez FA, et al. (2013) Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS): tips and tricks. J Gastrointest Surg 17(4):814–821

    Article  PubMed  Google Scholar 

  34. Brancatisano R, Isla A, Habib N (1998) Is radical hepatic surgery safe? Am J Surg 175(2):161–163

    Article  CAS  PubMed  Google Scholar 

  35. Dahm F, Georgiev P, Clavien PA (2005) Small-for-size syndrome after partial liver transplantation: definition, mechanisms of disease and clinical implications. Am J Transplant 5(11):2605–2610

    Article  PubMed  Google Scholar 

  36. Giacchetti S, et al. (1999) Long-term survival of patients with unresectable colorectal cancer liver metastases following infusional chemotherapy with 5-fluorouracil, leucovorin, oxaliplatin and surgery. Ann Oncol 10(6):663–669

    Article  CAS  PubMed  Google Scholar 

  37. Capussotti L, et al. (2008) Portal vein ligation as an efficient method of increasing the future liver remnant volume in the surgical treatment of colorectal metastases. Arch Surg 143(10):978–982 (discussion 982)

    Article  PubMed  Google Scholar 

  38. Knoefel WT, et al. (2013) In situ liver transection with portal vein ligation for rapid growth of the future liver remnant in two-stage liver resection. Br J Surg 100(3):388–394

    Article  CAS  PubMed  Google Scholar 

  39. Abulkhir A, et al. (2008) Preoperative portal vein embolization for major liver resection: a meta-analysis. Ann Surg 247(1):49–57

    Article  PubMed  Google Scholar 

Download references

Disclosures

Maansi Parekh, Michael Kluger, Adam Griesemer, and Stuart Bentley–Hibbert have no disclosures.

Author information

Authors and Affiliations

  1. Columbia University Medical Center, 622 W, 168 Street, PB 1-301, New York, NY, 10032, USA

    Maansi Parekh, Michael D. Kluger, Adam Griesemer & Stuart Bentley–Hibbert

Authors
  1. Maansi Parekh
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Michael D. Kluger
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Adam Griesemer
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Stuart Bentley–Hibbert
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Maansi Parekh.

Additional information

IRB statement: Columbia University institutional review board approved this study.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Parekh, M., D. Kluger, M., Griesemer, A. et al. Regenerative liver surgeries: the alphabet soup of emerging techniques. Abdom Radiol 41, 162–173 (2016). https://doi.org/10.1007/s00261-015-0606-6

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00261-015-0606-6

Keywords

Search

Navigation