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Feasibility of detecting small intestinal disease by FDG-PET/CT

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Abstract

Positron emission tomography (PET)/computed tomography with 18F-fluorodeoxyglucose (FDG) is widely used for the diagnosis of malignant tumors. However, we occasionally encounter cases in which pathological accumulation is indistinguishable from physiological accumulation. We conducted a retrospective study of the maximum standardized uptake value (SUVmax) and the distribution pattern of FDG accumulation in 80 evaluable patients with records of accumulation in the small intestine identified from data acquired at Dokkyo Medical University PET Center from March 2005 to December 2010. Our aim was to distinguish pathological accumulation from physiological accumulation. Nineteen of the 80 patients had lesions that required some form of treatment. These lesions were categorized as pathological accumulation, while other 65 lesions in 61 patients were categorized as physiological accumulation. Cases with diffuse accumulation in the intestinal tract were assigned to Group L (linear), all others to Group F (focal), in our analysis. Lesions were focal in 22 patients and linear in 62. The pathological accumulation group had a mean SUVmax of 12.2, which was higher than that of 5.0 in the physiological accumulation group, and included more lesions that were categorized into Group F (16 of 19 lesions). The sensitivity and specificity for detecting focal accumulation regarded as being pathological accumulation were 84% and 91%, respectively, and accuracy was 89%. The sensitivity and specificity with a cut-off SUVmax of 5.87 obtained in the ROC analysis were 84% and 78%, respectively, and accuracy was 80%. Evaluation of SUVmax in the small intestine and the distribution pattern of FDG accumulation may be useful for diagnosing lesions in the small intestine.

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The authors declare that they have no conflict of interest.

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Informed consent was obtained from all individual participants included in the study.

Research involving human participants and/or animals

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study formal consent is not required.

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Authors and Affiliations

  1. Department of Gastroenterology, Dokkyo Medical University, 880, Kitakobayashi, Mibu, Shimotsuga, Tochigi, 321-0293, Japan

    Takeshi Sugaya, Keiichi Tominaga, Masakazu Nakano, Hitoshi Sugaya & Hideyuki Hiraishi

  2. PET Center, Dokkyo Medical University, Tochigi, Japan

    Setsu Sakamoto

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  1. Takeshi Sugaya
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  2. Setsu Sakamoto
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  3. Keiichi Tominaga
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  4. Masakazu Nakano
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  5. Hitoshi Sugaya
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  6. Hideyuki Hiraishi
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Correspondence to Takeshi Sugaya.

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Sugaya, T., Sakamoto, S., Tominaga, K. et al. Feasibility of detecting small intestinal disease by FDG-PET/CT. Abdom Imaging 40, 2193–2199 (2015). https://doi.org/10.1007/s00261-015-0457-1

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  • DOI: https://doi.org/10.1007/s00261-015-0457-1

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