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Assessing splenic enlargement on CT by unidimensional measurement changes in patients with colorectal liver metastases

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Abstract

Purpose

The aim of this study was to assess splenic volume and to correlate unidimensional measurements with reference volumetric changes in chemotherapy-treated patients with colorectal cancer (CRC) liver metastases.

Methods

Forty consecutive patients were selected from the cohort of a previously reported study of chemotherapy-related morbidity following major hepatectomy for CRC liver metastases. Patients were treated for 6 months prior to resection, with imaging performed at baseline and after 6 months of chemotherapy. Three unidimensional spleen measurements were recorded—width, thickness, and height (W, T, and H). Reference splenic volume was measured at baseline and after chemotherapy. The best unidimensional splenic measurement was determined by regression analysis. The 95% CI for the predicted values and R 2 values was calculated for each regression. The percentage of volume increase at 6 months was calculated.

Results

W and H showed the highest correlation with splenic volume prior to and following chemotherapy (R 2 = 0.65–0.74, p < 0.001), while T showed a low correlation (R 2 = 0.11 and 0.18, p < 0.05). The mean reference splenic volume increased after 6 months of chemotherapy compared to baseline (326 vs. 278 mL). Splenic volume changes showed the highest correlation with changes in W (R 2 = 0.56, p < 0.001), then H (R 2 = 0.40, p < 0.001), but were not significantly correlated with changes in T (R 2 = 0.01, p = 0.055).

Conclusions

Our results show the potential utility of measuring changes in splenic width to predict clinically significant changes in splenic volume in chemotherapy-treated patients with CRC liver metastases.

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Acknowledgments

This research was partially funded by Grant numbers U54CA137788 and U54CA132378 from the National Cancer Institute (NCI) of the US National Institutes of Health (NIH), to the CCNY-MSKCC Partnership for Cancer Research Training & Community Outreach.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Sophie Davis School of Biomedical Education, The City College of New York, 160 Convent Ave, New York, NY, 10031, USA

    Breanna J. Joiner

  2. Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY, 10065, USA

    Amber L. Simpson, Julie N. Leal & Michael I. D’Angelica

  3. Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY, 10065, USA

    Amber L. Simpson & Richard K. G. Do

Authors
  1. Breanna J. Joiner
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  2. Amber L. Simpson
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  3. Julie N. Leal
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  4. Michael I. D’Angelica
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  5. Richard K. G. Do
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Correspondence to Richard K. G. Do.

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Joiner, B.J., Simpson, A.L., Leal, J.N. et al. Assessing splenic enlargement on CT by unidimensional measurement changes in patients with colorectal liver metastases. Abdom Imaging 40, 2338–2344 (2015). https://doi.org/10.1007/s00261-015-0451-7

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  • DOI: https://doi.org/10.1007/s00261-015-0451-7

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