Abdominal Imaging

, Volume 40, Issue 1, pp 134–142

Detection of prostate cancer with multiparametric MRI (mpMRI): effect of dedicated reader education on accuracy and confidence of index and anterior cancer diagnosis

  • Kirema Garcia-Reyes
  • Niccolò M. Passoni
  • Mark L. Palmeri
  • Christopher R. Kauffman
  • Kingshuk Roy Choudhury
  • Thomas J. Polascik
  • Rajan T. Gupta
Article

DOI: 10.1007/s00261-014-0197-7

Cite this article as:
Garcia-Reyes, K., Passoni, N.M., Palmeri, M.L. et al. Abdom Imaging (2015) 40: 134. doi:10.1007/s00261-014-0197-7

Abstract

Purpose

To evaluate the impact of dedicated reader education on accuracy/confidence of peripheral zone index cancer and anterior prostate cancer (PCa) diagnosis with mpMRI; secondary aim was to assess the ability of readers to differentiate low-grade cancer (Gleason 6 or below) from high-grade cancer (Gleason 7+).

Materials and methods

Five blinded radiology fellows evaluated 31 total prostate mpMRIs in this IRB-approved, HIPAA-compliant, retrospective study for index lesion detection, confidence in lesion diagnosis (1–5 scale), and Gleason grade (Gleason 6 or lower vs. Gleason 7+). Following a dedicated education program, readers reinterpreted cases after a memory extinction period, blinded to initial reads. Reference standard was established combining whole mount histopathology with mpMRI findings by a board-certified radiologist with 5 years of prostate mpMRI experience.

Results

Index cancer detection: pre-education accuracy 74.2%; post-education accuracy 87.7% (p = 0.003). Confidence in index lesion diagnosis: pre-education 4.22 ± 1.04; post-education 3.75 ± 1.41 (p = 0.0004). Anterior PCa detection: pre-education accuracy 54.3%; post-education accuracy 94.3% (p = 0.001). Confidence in anterior PCa diagnosis: pre-education 3.22 ± 1.54; post-education 4.29 ± 0.83 (p = 0.0003). Gleason score accuracy: pre-education 54.8%; post-education 73.5% (p = 0.0005).

Conclusions

A dedicated reader education program on PCa detection with mpMRI was associated with a statistically significant increase in diagnostic accuracy of index cancer and anterior cancer detection as well as Gleason grade identification as compared to pre-education values. This was also associated with a significant increase in reader diagnostic confidence. This suggests that substantial interobserver variability in mpMRI interpretation can potentially be reduced with a focus on education and that this can occur over a fellowship training year.

Keywords

Prostate cancer Multiparametric prostate MRI Reader education 

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Kirema Garcia-Reyes
    • 1
  • Niccolò M. Passoni
    • 2
  • Mark L. Palmeri
    • 3
  • Christopher R. Kauffman
    • 1
  • Kingshuk Roy Choudhury
    • 1
  • Thomas J. Polascik
    • 2
  • Rajan T. Gupta
    • 1
  1. 1.Department of RadiologyDuke University Medical CenterDurhamUSA
  2. 2.Division of Urologic Surgery and Duke Prostate Center, Department of SurgeryDuke University Medical CenterDurhamUSA
  3. 3.Department of Biomedical EngineeringDuke UniversityDurhamUSA

Personalised recommendations