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Abdominal Imaging

, Volume 39, Issue 4, pp 744–752 | Cite as

Pancreatic adenocarcinoma: a pilot study of quantitative perfusion and diffusion-weighted breath-hold magnetic resonance imaging

  • Hyunki Kim
  • Pablo J. Arnoletti
  • John Christein
  • Martin J. Heslin
  • James A. Posey III
  • Amol Pednekar
  • T. Mark Beasley
  • Desiree E. Morgan
Article

Abstract

Purpose

To confirm the feasibility of breath-hold DCE-MRI and DWI at 3T to obtain the intra-abdominal quantitative physiologic parameters, K trans, k ep, and ADC, in patients with untreated pancreatic ductal adenocarcinomas.

Methods

Diffusion-weighted single-shot echo-planar imaging (DW-SS-EPI) and dynamic contrast-enhanced (DCE) MRI were used for 16 patients with newly diagnosed biopsy-proven pancreatic ductal adenocarcinomas. K trans, k ep, and apparent diffusion coefficient (ADC) values of pancreatic tumors, non-tumor adjacent pancreatic parenchyma (NAP), liver metastases, and normal liver tissues were quantitated and statistically compared.

Results

Fourteen patients were able to adequately hold their breath for DCE-MRI, and 15 patients for DW-SS-EPI. Four patients had liver metastases within the 6 cm of Z axis coverage centered on the pancreatic primary tumors. K trans values (10−3 min−1) of primary pancreatic tumors, NAP, liver metastases, and normal liver tissues were 7.3 ± 4.2 (mean ± SD), 25.8 ± 14.9, 8.1 ± 5.9, and 45.1 ± 15.6, respectively, k ep values (10−2 min−1) were 3.0 ± 0.9, 7.4 ± 3.1, 5.2 ± 2.0, and 12.1 ± 2.8, respectively, and ADC values (10−3 mm2/s) were 1.3 ± 0.2, 1.6 ± 0.3, 1.1 ± 0.1, and 1.3 ± 0.1, respectively. K trans, k ep, and ADC values of primary pancreatic tumors were significantly lower than those of NAP (p < 0.05), while K trans and k ep values of liver metastases were significantly lower than those of normal liver tissues (p < 0.05).

Conclusions

3T breath-hold quantitative physiologic MRI is a feasible technique that can be applied to a majority of patients with pancreatic adenocarcinomas.

Keywords

DCE-MRI DWI Pancreatic adenocarcinoma 

Notes

Grant support

Research Initiative Pilot Award from the Department of Radiology at UAB and NIH grant 2P30CA013148.

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Hyunki Kim
    • 1
    • 2
    • 6
    • 9
  • Pablo J. Arnoletti
    • 7
  • John Christein
    • 3
  • Martin J. Heslin
    • 3
  • James A. Posey III
    • 4
  • Amol Pednekar
    • 8
  • T. Mark Beasley
    • 5
  • Desiree E. Morgan
    • 1
    • 6
  1. 1.Departments of RadiologyUniversity of Alabama at BirminghamBirminghamUSA
  2. 2.Biomedical EngineeringUniversity of Alabama at BirminghamBirminghamUSA
  3. 3.Department of SurgeryUniversity of Alabama at BirminghamBirminghamUSA
  4. 4.Department of MedicineUniversity of Alabama at BirminghamBirminghamUSA
  5. 5.Department of BiostatisticsUniversity of Alabama at BirminghamBirminghamUSA
  6. 6.Comprehensive Cancer CenterUniversity of Alabama at BirminghamBirminghamUSA
  7. 7.The Center for Specialized SurgeryOrlandoPhilips
  8. 8.Medical SystemsBothellUSA
  9. 9.BirminghamUSA

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