Skip to main content
SpringerLink
Log in

Liver adenomatosis: serial investigation on MRI

  • Published:
Abdominal Imaging Aims and scope Submit manuscript

Abstract

Purpose

To describe the natural history of liver adenomatosis (LA), including complications and changes in lesion size over time.

Materials and methods

Eighteen patients with clinical diagnosis of LA were included. Clinical and biochemical information were collected. The initial and follow-up MR studies were reviewed retrospectively to determine change in lesion size and imaging features.

Results

Seventeen patients were women (94.4%). The mean age of the initial MR study was 37.0 years (18–52 years). The median size of the largest lesion was 6.7 cm (range 3.0–13.5 cm). Intratumoral bleeding was detected on MRI in 9 lesions, in 7 patients (38.8%). The median size for hemorrhagic lesions was 7.6 cm (range 4.1–13.5 cm). During the mean follow-up period of 29.4 (range 4–98) months, 10 patients had stable disease (55.6%), and 8 patients had tumor regression (44.4%). Of 8 patients who were followed without intervention, 3 patients (37.5%) had spontaneous regression. No malignant transformation or lesion progression was occurred.

Conclusion

During an over 2-year follow-up period, the majority of lesions of LA appeared to remain stable or showed tumor regression. Spontaneous tumor regression can be observed in approximately 37% of individuals in the age range of 28–53 years.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Dokmak S, Paradis V, Vilgrain V, et al. (2009) A single-center surgical experience of 122 patients with single and multiple hepatocellular adenomas. Gastroenterology 137:1698–1705

    Article  PubMed  Google Scholar 

  2. Flejou J, Barge J, Menu Y, et al. (1985) Liver adenomatosis. An entity distinct from liver adenoma? Gastroenterology 89:1132

    CAS  PubMed  Google Scholar 

  3. Bioulac-Sage P, Laumonier H, Couchy G, et al. (2009) Hepatocellular adenoma management and phenotypic classification: the Bordeaux experience. Hepatology 50:481–489

    Article  PubMed  Google Scholar 

  4. Deneve JL, Pawlik TM, Cunningham S, et al. (2009) Liver cell adenoma: a multicenter analysis of risk factors for rupture and malignancy. Ann Surg Oncol 16:640–648

    Article  PubMed  Google Scholar 

  5. Svrcek M, Jeannot E, Arrive L, et al. (2007) Regressive liver adenomatosis following androgenic progestin therapy withdrawal: a case report with a 10-year follow-up and a molecular analysis. Eur J Endocrinol 156:617–621

    Article  CAS  PubMed  Google Scholar 

  6. Vetelainen R, Erdogan D, de Graaf W, et al. (2008) Liver adenomatosis: re-evaluation of aetiology and management. Liver Int 28:499–508

    Article  PubMed  Google Scholar 

  7. Raman SP, Hruban RH, Fishman EK (2013) Hepatic adenomatosis: spectrum of imaging findings. Abdom Imaging 38(3):474–481

    Article  PubMed  Google Scholar 

  8. Goodwin MD, Dobson JE, Sirlin CB, Lim BG, Stella DL (2011) Diagnostic challenges and pitfalls in MR imaging with hepatocyte-specific contrast agents. Radiographics 31:1547–1568

    Article  PubMed  Google Scholar 

  9. Rebouissou S, Bioulac-Sage P, Zucman-Rossi J (2008) Molecular pathogenesis of focal nodular hyperplasia and hepatocellular adenoma. J Hepatol 48:163–170

    Article  CAS  PubMed  Google Scholar 

  10. Zucman-Rossi J, Jeannot E, Nhieu JT, et al. (2006) Genotype–phenotype correlation in hepatocellular adenoma: new classification and relationship with HCC. Hepatology 43:515–524

    Article  CAS  PubMed  Google Scholar 

  11. Bioulac-Sage P, Rebouissou S, Thomas C, et al. (2007) Hepatocellular adenoma subtype classification using molecular markers and immunohistochemistry. Hepatology 46:740–748

    Article  CAS  PubMed  Google Scholar 

  12. Laumonier H, Bioulac-Sage P, Laurent C, et al. (2008) Hepatocellular adenomas: magnetic resonance imaging features as a function of molecular pathological classification. Hepatology 48:808–818

    Article  PubMed  Google Scholar 

  13. Ronot M, Bahrami S, Calderaro J, et al. (2011) Hepatocellular adenomas: accuracy of magnetic resonance imaging and liver biopsy in subtype classification. Hepatology 53:1182–1191

    Article  PubMed  Google Scholar 

  14. Grazioli L, Federle MP, Ichikawa T, et al. (2000) Liver adenomatosis: clinical, histopathologic, and imaging findings in 15 patients. Radiology 216:395–402

    Article  CAS  PubMed  Google Scholar 

  15. Bunchorntavakul C, Bahirwani R, Drazek D, et al. (2011) Clinical features and natural history of hepatocellular adenomas: the impact of obesity. Aliment Pharmacol Ther 34:664–674

    Article  CAS  PubMed  Google Scholar 

  16. Furlan A, van der Windt DJ, Nalesnik MA, et al. (2008) Multiple hepatic adenomas associated with liver steatosis at CT and MRI: a case–control study. Am J Roentgenol 191:1430–1435

    Article  Google Scholar 

  17. Kobayashi S, Sakaguchi H, Takatsuka M, et al. (2009) Two cases of hepatocellular adenomatosis treated with transcatheter arterial embolization. Hepatol Int 3:416–420

    Article  PubMed Central  PubMed  Google Scholar 

  18. Stoot JH, Coelen RJ, De Jong MC, Dejong CH (2010) Malignant transformation of hepatocellular adenomas into hepatocellular carcinomas: a systematic review including more than 1600 adenoma cases. HPB 12:509–522

    Article  PubMed Central  PubMed  Google Scholar 

  19. Arita J, Sugawara Y, Hashimoto T, et al. (2003) Liver resection in patients with Gilbert’s syndrome. Surgery 134:835–837

    Article  PubMed  Google Scholar 

  20. Radu P, Atsmon J (2001) Gilbert’s syndrome—clinical and pharmacological implications. Isr Med Assoc J 3:593–598

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Radiology, University of North Carolina at Chapel Hill, Old Clinic Bldg, CB 7510 – 2001, Chapel Hill, NC, 27599-7510, USA

    Saowanee Srirattanapong, Wirana Angthong, Bong Soo Kim, Anuruddika Ranatunga & Richard C. Semelka

  2. Department of Diagnostic and Therapeutic Radiology Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

    Saowanee Srirattanapong

  3. Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

    Paul Hideyo Hayashi

  4. Division of Abdominal Transplant, Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

    David A. Gerber

  5. Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

    John T. Woosley

  6. Department of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

    Jared Peacock

Authors
  1. Saowanee Srirattanapong
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Wirana Angthong
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Bong Soo Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Paul Hideyo Hayashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. David A. Gerber
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. John T. Woosley
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Jared Peacock
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Anuruddika Ranatunga
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Richard C. Semelka
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Richard C. Semelka.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Srirattanapong, S., Angthong, W., Kim, B.S. et al. Liver adenomatosis: serial investigation on MRI. Abdom Imaging 39, 269–282 (2014). https://doi.org/10.1007/s00261-013-0056-y

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00261-013-0056-y

Key words:

Search

Navigation