Skip to main content

Advertisement

Log in

Staging, surveillance, and evaluation of response to therapy in renal cell carcinoma: role of MDCT

  • Published:
Abdominal Imaging Aims and scope Submit manuscript

Abstract

Renal cell carcinoma is the most common malignant renal tumor in the adults. Significant advances have been made in the management of localized and advanced renal cell carcinoma. Surgery is the standard of care and accurate pre-operative staging based on imaging is critical in guiding appropriate patient management. Besides staging, imaging plays a key role in the post-operative surveillance and evaluation of response to systemic therapies. Both CT and MR are useful in the staging and follow up of renal cell carcinoma, but CT is more commonly used due to its lower costs and wider availability. In this article, we discuss and illustrate the role of multi-detector CT in pre-operative staging, post-operative surveillance, and evaluation of response to systemic therapy in renal cell carcinoma.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10
Fig. 11
Fig. 12
Fig. 13
Fig. 14
Fig. 15
Fig. 16
Fig. 17
Fig. 18
Fig. 19
Fig. 20

Similar content being viewed by others

References

  1. Pantuck AJ, Zisman A, Belldegrun AS (2001) The changing natural history of renal cell carcinoma. J Urol 166(5):1611–1623

    Article  CAS  PubMed  Google Scholar 

  2. American Cancer Society (2013) Cancer facts and figures 2013. American Cancer Society. http://www.cancer.org/acs/groups/content/@epidemiologysurveilance/documents/document/acspc-036845.pdf. Accessed 15 June 2013

  3. Campbell SC, Novick AC, Belldegrun A, et al. (2009) Guideline for management of the clinical T1 renal mass. J Urol 182(4):1271–1279. doi:10.1016/j.juro.2009.07.004

    Article  PubMed  Google Scholar 

  4. Edge S (2010) American Joint Committee on Cancer. AJCC cancer staging manual. 7th edn. Springer, New York

  5. Jinzaki M, McTavish JD, Zou KH, Judy PF, Silverman SG (2004) Evaluation of small (</= 3 cm) renal masses with MDCT: benefits of thin overlapping reconstructions. AJR Am J Roentgenol 183(1):223–228. doi:10.2214/ajr.183.1.1830223

    Article  PubMed  Google Scholar 

  6. Hallscheidt PJ, Bock M, Riedasch G, et al. (2004) Diagnostic accuracy of staging renal cell carcinomas using multidetector-row computed tomography and magnetic resonance imaging: a prospective study with histopathologic correlation. J Comput Assist Tomogr 28(3):333–339

    Article  PubMed  Google Scholar 

  7. Hallscheidt PJ, Fink C, Haferkamp A, et al. (2005) Preoperative staging of renal cell carcinoma with inferior vena cava thrombus using multidetector CT and MRI: prospective study with histopathological correlation. J Comput Assist Tomogr 29(1):64–68

    Article  PubMed  Google Scholar 

  8. Sheth S, Scatarige JC, Horton KM, Corl FM, Fishman EK (2001) Current concepts in the diagnosis and management of renal cell carcinoma: role of multidetector ct and three-dimensional CT. Radiographics 21:S237–S254

    Google Scholar 

  9. Cohan RH, Sherman LS, Korobkin M, Bass JC, Francis IR (1995) Renal masses: assessment of corticomedullary-phase and nephrographic-phase CT scans. Radiology 196(2):445–451

    CAS  PubMed  Google Scholar 

  10. Szolar DH, Kammerhuber F, Altziebler S, et al. (1997) Multiphasic helical CT of the kidney: increased conspicuity for detection and characterization of small (<3-cm) renal masses. Radiology 202(1):211–217

    CAS  PubMed  Google Scholar 

  11. Zeman RK, Zeiberg A, Hayes WS, et al. (1996) Helical CT of renal masses: the value of delayed scans. AJR Am J Roentgenol 167(3):771–776. doi:10.2214/ajr.167.3.8751698

    Article  CAS  PubMed  Google Scholar 

  12. Johnson PT, Horton KM, Fishman EK (2010) How not to miss or mischaracterize a renal cell carcinoma: protocols, pearls, and pitfalls. AJR Am J Roentgenol 194(4):W307–W315. doi:10.2214/ajr.09.3033

    Article  PubMed  Google Scholar 

  13. Pooler BD, Pickhardt PJ, O’Connor SD, et al. (2012) Renal cell carcinoma: attenuation values on unenhanced CT. AJR Am J Roentgenol 198(5):1115–1120. doi:10.2214/ajr.11.7587

    Article  PubMed  Google Scholar 

  14. Yuh BI, Cohan RH (1999) Different phases of renal enhancement: role in detecting and characterizing renal masses during helical CT. AJR Am J Roentgenol 173(3):747–755. doi:10.2214/ajr.173.3.10470916

    Article  CAS  PubMed  Google Scholar 

  15. Ficarra V, Novara G, Iafrate M et al (2007) Proposal for reclassification of the TNM staging system in patients with locally advanced (pT3-4) renal cell carcinoma according to the cancer-related outcome. Eur Urol 51(3):722–729; discussion 729–731. doi:10.1016/j.eururo.2006.07.010

    Google Scholar 

  16. Van Poppel H, Da Pozzo L, Albrecht W, et al. (2011) A prospective, randomised EORTC intergroup phase 3 study comparing the oncologic outcome of elective nephron-sparing surgery and radical nephrectomy for low-stage renal cell carcinoma. Eur Urol 59(4):543–552. doi:10.1016/j.eururo.2010.12.013

    Article  PubMed  Google Scholar 

  17. Fergany AF, Hafez KS, Novick AC (2000) Long-term results of nephron sparing surgery for localized renal cell carcinoma: 10-year followup. J Urol 163(2):442–445

    Article  CAS  PubMed  Google Scholar 

  18. Huang WC, Levey AS, Serio AM, et al. (2006) Chronic kidney disease after nephrectomy in patients with renal cortical tumours: a retrospective cohort study. Lancet Oncol 7(9):735–740. doi:10.1016/s1470-2045(06)70803-8

    Article  PubMed  PubMed Central  Google Scholar 

  19. Huang WC, Elkin EB, Levey AS, Jang TL, Russo P (2009) Partial nephrectomy versus radical nephrectomy in patients with small renal tumors–is there a difference in mortality and cardiovascular outcomes? J Urol 181 (1):55–61; discussion 61–52. doi:10.1016/j.juro.2008.09.017

    Google Scholar 

  20. Fergany AF, Saad IR, Woo L, Novick AC (2006) Open partial nephrectomy for tumor in a solitary kidney: experience with 400 cases. J Urol 175(5):1630–1633; discussion 1633. doi:10.1016/s0022-5347(05)00991-2

    Google Scholar 

  21. Gill IS, Kavoussi LR, Lane BR, et al. (2007) Comparison of 1,800 laparoscopic and open partial nephrectomies for single renal tumors. J Urol 178(1):41–46. doi:10.1016/j.juro.2007.03.038

    Article  PubMed  Google Scholar 

  22. Gautam G, Benway BM, Bhayani SB, Zorn KC (2009) Robot-assisted partial nephrectomy: current perspectives and future prospects. Urology 74(4):735–740. doi:10.1016/j.urology.2009.03.041

    Article  PubMed  Google Scholar 

  23. Wang L, Lee BR (2013) Robotic partial nephrectomy: current technique and outcomes. Int J Urol . doi:10.1111/iju.12177

    Google Scholar 

  24. Karellas ME, O’Brien MF, Jang TL, Bernstein M, Russo P (2010) Partial nephrectomy for selected renal cortical tumours of >/= 7 cm. BJU Int 106(10):1484–1487. doi:10.1111/j.1464-410X.2010.09405.x

    Article  PubMed  Google Scholar 

  25. Lee SE, Lee WK, Kim DS, et al. (2010) Comparison of radiographic and pathologic sizes of renal tumors. World J Urol 28(3):263–267. doi:10.1007/s00345-010-0511-0

    Article  PubMed  Google Scholar 

  26. Van Poppel H, Da Pozzo L, Albrecht W, et al. (2007) A prospective randomized EORTC intergroup phase 3 study comparing the complications of elective nephron-sparing surgery and radical nephrectomy for low-stage renal cell carcinoma. Eur Urol 51(6):1606–1615. doi:10.1016/j.eururo.2006.11.013

    Article  PubMed  Google Scholar 

  27. Ficarra V, Novara G, Secco S, et al. (2009) Preoperative aspects and dimensions used for an anatomical (PADUA) classification of renal tumours in patients who are candidates for nephron-sparing surgery. Eur Urol 56(5):786–793. doi:10.1016/j.eururo.2009.07.040

    Article  PubMed  Google Scholar 

  28. Kutikov A, Uzzo RG (2009) The R.E.N.A.L. nephrometry score: a comprehensive standardized system for quantitating renal tumor size, location and depth. J Urol 182(3):844–853. doi:10.1016/j.juro.2009.05.035

    Article  PubMed  Google Scholar 

  29. Simmons MN, Ching CB, Samplaski MK, Park CH, Gill IS (2010) Kidney tumor location measurement using the C index method. J Urol 183(5):1708–1713. doi:10.1016/j.juro.2010.01.005

    Article  PubMed  Google Scholar 

  30. Hallscheidt P, Wagener N, Gholipour F, et al. (2006) Multislice computed tomography in planning nephron-sparing surgery in a prospective study with 76 patients: comparison of radiological and histopathological findings in the infiltration of renal structures. J Comput Assist Tomogr 30(6):869–874. doi:10.1097/01.rct.0000230009.31715.5b

    Article  PubMed  Google Scholar 

  31. Secil M, Elibol C, Aslan G, et al. (2011) Role of intraoperative US in the decision for radical or partial nephrectomy. Radiology 258(1):283–290. doi:10.1148/radiol.10100859

    Article  PubMed  Google Scholar 

  32. Karlo CA, Di Paolo PL, Donati OF, et al. (2013) Renal cell carcinoma: role of MR imaging in the assessment of muscular venous branch invasion. Radiology 267(2):454–459. doi:10.1148/radiol.13121555

    Article  PubMed  Google Scholar 

  33. Catalano C, Fraioli F, Laghi A, et al. (2003) High-resolution multidetector CT in the preoperative evaluation of patients with renal cell carcinoma. AJR Am J Roentgenol 180(5):1271–1277. doi:10.2214/ajr.180.5.1801271

    Article  CAS  PubMed  Google Scholar 

  34. Komoda T, Hetzer R, Oellinger J, et al. (1997) Imaging of the orifice of the left ventricular outflow tract: technique and initial results. Technol Health Care 5(3):207–217

    CAS  PubMed  Google Scholar 

  35. Johnson CD, Dunnick NR, Cohan RH, Illescas FF (1987) Renal adenocarcinoma: CT staging of 100 tumors. AJR Am J Roentgenol 148(1):59–63. doi:10.2214/ajr.148.1.59

    Article  CAS  PubMed  Google Scholar 

  36. Yamashita Y, Takahashi M, Watanabe O, et al. (1992) Small renal cell carcinoma: pathologic and radiologic correlation. Radiology 184(2):493–498

    CAS  PubMed  Google Scholar 

  37. Minervini A, di Cristofano C, Lapini A, et al. (2009) Histopathologic analysis of peritumoral pseudocapsule and surgical margin status after tumor enucleation for renal cell carcinoma. Eur Urol 55(6):1410–1418. doi:10.1016/j.eururo.2008.07.038

    Article  PubMed  Google Scholar 

  38. Kallman DA, King BF, Hattery RR, et al. (1992) Renal vein and inferior vena cava tumor thrombus in renal cell carcinoma: CT, US, MRI and venacavography. J Comput Assist Tomogr 16(2):240–247

    Article  CAS  PubMed  Google Scholar 

  39. Kearney GP, Waters WB, Klein LA, Richie JP, Gittes RF (1981) Results of inferior vena cava resection for renal cell carcinoma. J Urol 125(6):769–773

    CAS  PubMed  Google Scholar 

  40. Sengupta S, Zincke H, Leibovich BC, Blute ML (2005) Surgical treatment of stage pT3b renal cell carcinoma in solitary kidneys: a case series. BJU Int 96(1):54–57. doi:10.1111/j.1464-410X.2005.05566.x

    Article  PubMed  Google Scholar 

  41. Neves RJ, Zincke H (1987) Surgical treatment of renal cancer with vena cava extension. Br J Urol 59(5):390–395

    Article  CAS  PubMed  Google Scholar 

  42. Novick A (1989) Stewart’s Operative Urology. 2nd edn. Williams & Wilkins, Baltimore

  43. Boorjian SA, Sengupta S, Blute ML (2007) Renal cell carcinoma: vena caval involvement. BJU Int 99(5 Pt B):1239–1244. doi:10.1111/j.1464-410X.2007.06826.x

  44. Karnes RJ, Blute ML (2008) Surgery insight: management of renal cell carcinoma with associated inferior vena cava thrombus. Nat Clin Pract Urol 5(6):329–339. doi:10.1038/ncpuro1122

    PubMed  Google Scholar 

  45. Goldfarb DA, Novick AC, Lorig R et al (1990) Magnetic resonance imaging for assessment of vena caval tumor thrombi: a comparative study with venacavography and computerized tomography scanning. J Urol 144(5):1100–1103; discussion 1103–1104

    Google Scholar 

  46. Guzzo TJ, Pierorazio PM, Schaeffer EM, Fishman EK, Allaf ME (2009) The accuracy of multidetector computerized tomography for evaluating tumor thrombus in patients with renal cell carcinoma. J Urol 181(2):486–490; discussion 491. doi:10.1016/j.juro.2008.10.040

    Google Scholar 

  47. Lawrentschuk N, Gani J, Riordan R, Esler S, Bolton DM (2005) Multidetector computed tomography vs magnetic resonance imaging for defining the upper limit of tumour thrombus in renal cell carcinoma: a study and review. BJU Int 96(3):291–295. doi:10.1111/j.1464-410X.2005.05617.x

    Article  PubMed  Google Scholar 

  48. Woodruff DY, Van Veldhuizen P, Muehlebach G, et al. (2011) The perioperative management of an inferior vena caval tumor thrombus in patients with renal cell carcinoma. Urol Oncol . doi:10.1016/j.urolonc.2011.03.006

    PubMed  Google Scholar 

  49. Boorjian SA, Blute ML (2009) Surgery for vena caval tumor extension in renal cancer. Curr Opin Urol 19(5):473–477. doi:10.1097/MOU.0b013e32832f0aba

    Article  PubMed  Google Scholar 

  50. Zini L, Destrieux-Garnier L, Leroy X et al (2008) Renal vein ostium wall invasion of renal cell carcinoma with an inferior vena cava tumor thrombus: prediction by renal and vena caval vein diameters and prognostic significance. J Urol 179(2):450–454; discussion 454. doi:10.1016/j.juro.2007.09.042

  51. Aslam Sohaib SA, Teh J, Nargund VH, et al. (2002) Assessment of tumor invasion of the vena caval wall in renal cell carcinoma cases by magnetic resonance imaging. J Urol 167(3):1271–1275

    Article  CAS  PubMed  Google Scholar 

  52. Gohji K, Yamashita C, Ueno K, Shimogaki H, Kamidono S (1994) Preoperative computerized tomography detection of extensive invasion of the inferior vena cava by renal cell carcinoma: possible indication for resection with partial cardiopulmonary bypass and patch grafting. J Urol 152(6 Pt 1):1993–1996; discussion 1997

    Google Scholar 

  53. Ng CS, Wood CG, Silverman PM, et al. (2008) Renal cell carcinoma: diagnosis, staging, and surveillance. AJR Am J Roentgenol 191(4):1220–1232. doi:10.2214/ajr.07.3568

    Article  PubMed  Google Scholar 

  54. Bekema HJ, Maclennan S, Imamura M, et al. (2013) Systematic review of adrenalectomy and lymph node dissection in locally advanced renal cell carcinoma. Eur Urol. doi:10.1016/j.eururo.2013.04.033

    PubMed  Google Scholar 

  55. Kobayashi T, Nakamura E, Yamamoto S, et al. (2003) Low incidence of ipsilateral adrenal involvement and recurrences in patients with renal cell carcinoma undergoing radical nephrectomy: a retrospective analysis of 393 patients. Urology 62(1):40–45

    Article  PubMed  Google Scholar 

  56. O’Malley RL, Godoy G, Kanofsky JA, Taneja SS (2009) The necessity of adrenalectomy at the time of radical nephrectomy: a systematic review. J Urol 181(5):2009–2017. doi:10.1016/j.juro.2009.01.018

    Article  PubMed  Google Scholar 

  57. Robey EL, Schellhammer PF (1986) The adrenal gland and renal cell carcinoma: is ipsilateral adrenalectomy a necessary component of radical nephrectomy? J Urol 135(3):453–455

    CAS  PubMed  Google Scholar 

  58. Siemer S, Lehmann J, Kamradt J et al (2004) Adrenal metastases in 1635 patients with renal cell carcinoma: outcome and indication for adrenalectomy. J Urol 171(6 Pt 1):2155–2159; discussion 2159

    Google Scholar 

  59. Tsui KH, Shvarts O, Barbaric Z, et al. (2000) Is adrenalectomy a necessary component of radical nephrectomy? UCLA experience with 511 radical nephrectomies. J Urol 163(2):437–441

    Article  CAS  PubMed  Google Scholar 

  60. Gill IS, McClennan BL, Kerbl K, et al. (1994) Adrenal involvement from renal cell carcinoma: predictive value of computerized tomography. J Urol 152(4):1082–1085

    CAS  PubMed  Google Scholar 

  61. O’Brien WM, Lynch JH (1987) Adrenal metastases by renal cell carcinoma. Incidence at nephrectomy. Urology 29(6):605–607

    Article  PubMed  Google Scholar 

  62. Antonelli A, Cozzoli A, Simeone C, et al. (2006) Surgical treatment of adrenal metastasis from renal cell carcinoma: a single-centre experience of 45 patients. BJU Int 97(3):505–508. doi:10.1111/j.1464-410X.2006.05934.x

    Article  PubMed  Google Scholar 

  63. Margulis V, Sanchez-Ortiz RF, Tamboli P, et al. (2007) Renal cell carcinoma clinically involving adjacent organs: experience with aggressive surgical management. Cancer 109(10):2025–2030. doi:10.1002/cncr.22629

    Article  PubMed  Google Scholar 

  64. Chapin BF, Delacroix SEJr, Wood CG (2011) Renal cell carcinoma: what the surgeon and treating physician need to know. AJR Am J Roentgenol 196(6):1255–1262. doi:10.2214/ajr.10.6249

    Article  PubMed  Google Scholar 

  65. Urban BA, Ratner LE, Fishman EK (2001) Three-dimensional volume-rendered CT angiography of the renal arteries and veins: normal anatomy, variants, and clinical applications. Radiographics 21(2):373–386; questionnaire 549–355

    Google Scholar 

  66. Wunderlich H, Reichelt O, Schubert R, Zermann DH, Schubert J (2000) Preoperative simulation of partial nephrectomy with three-dimensional computed tomography. BJU Int 86(7):777–781

    Article  CAS  PubMed  Google Scholar 

  67. Delacroix SEJr, Chapin BF, Chen JJ, et al. (2011) Can a durable disease-free survival be achieved with surgical resection in patients with pathological node positive renal cell carcinoma? J Urol 186(4):1236–1241. doi:10.1016/j.juro.2011.05.051

    Article  PubMed  Google Scholar 

  68. Whitson JM, Harris CR, Reese AC, Meng MV (2011) Lymphadenectomy improves survival of patients with renal cell carcinoma and nodal metastases. J Urol 185(5):1615–1620. doi:10.1016/j.juro.2010.12.053

    Article  PubMed  Google Scholar 

  69. Ming X, Ningshu L, Hanzhong L, Zhongming H, Tonghua L (2009) Value of frozen section analysis of enlarged lymph nodes during radical nephrectomy for renal cell carcinoma. Urology 74(2):364–368. doi:10.1016/j.urology.2008.12.075

    Article  PubMed  Google Scholar 

  70. Studer UE, Scherz S, Scheidegger J, et al. (1990) Enlargement of regional lymph nodes in renal cell carcinoma is often not due to metastases. J Urol 144(2 Pt 1):243–245

    CAS  PubMed  Google Scholar 

  71. Hutterer GC, Patard JJ, Perrotte P, et al. (2007) Patients with renal cell carcinoma nodal metastases can be accurately identified: external validation of a new nomogram. Int J Cancers 121(11):2556–2561. doi:10.1002/ijc.23010

    Article  CAS  Google Scholar 

  72. Crispen PL, Breau RH, Allmer C, et al. (2011) Lymph node dissection at the time of radical nephrectomy for high-risk clear cell renal cell carcinoma: indications and recommendations for surgical templates. Eur Urol 59(1):18–23. doi:10.1016/j.eururo.2010.08.042

    Article  PubMed  Google Scholar 

  73. Choudhary S, Sudarshan S, Choyke PL, Prasad SR (2009) Renal cell carcinoma: recent advances in genetics and imaging. Semin Ultrasound CT MR 30(4):315–325

    Article  PubMed  Google Scholar 

  74. de Reijke TM, Bellmunt J, van Poppel H, Marreaud S, Aapro M (2009) EORTC-GU group expert opinion on metastatic renal cell cancer. Eur J Cancer 45(5):765–773. doi:10.1016/j.ejca.2008.12.010

    Google Scholar 

  75. van der Veldt AA, Meijerink MR, van den Eertwegh AJ, Boven E (2010) Targeted therapies in renal cell cancer: recent developments in imaging. Targeted Oncol 5(2):95–112. doi:10.1007/s11523-010-0146-5

    Article  Google Scholar 

  76. Ljungberg B, Campbell SC, Choi HY, et al. (2011) The epidemiology of renal cell carcinoma. Eur Urol 60(4):615–621. doi:10.1016/j.eururo.2011.06.049

    Article  PubMed  Google Scholar 

  77. Tanriverdi O (2013) Review on targeted treatment of patients with advanced-stage renal cell carcinoma: a medical oncologist’s perspective. APJCP 14(2):609–617

    PubMed  Google Scholar 

  78. Abe H, Kamai T (2013) Recent advances in the treatment of metastatic renal cell carcinoma. Int J Urol . doi:10.1111/iju.12187

    Google Scholar 

  79. Bukowski RM (2001) Cytokine therapy for metastatic renal cell carcinoma. Semin Urol Oncol 19(2):148–154

    CAS  PubMed  Google Scholar 

  80. Sun M, Shariat SF, Trinh QD, et al. (2013) An evidence-based guide to the selection of sequential therapies in metastatic renal cell carcinoma. Ther Adv Urol 5(2):121–128. doi:10.1177/1756287212466128

    Article  PubMed  PubMed Central  Google Scholar 

  81. Choueiri TK (2013) Clinical treatment decisions for advanced renal cell cancer. JNCCN 11(5 Suppl):694–697

    CAS  PubMed  Google Scholar 

  82. Hudes G, Carducci M, Tomczak P, et al. (2007) Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med 356(22):2271–2281. doi:10.1056/NEJMoa066838

    Article  CAS  PubMed  Google Scholar 

  83. Sternberg CN, Davis ID, Mardiak J, et al. (2010) Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial. J Clin Oncol 28(6):1061–1068. doi:10.1200/jco.2009.23.9764

    Article  CAS  PubMed  Google Scholar 

  84. Motzer RJ, Hutson TE, Tomczak P, et al. (2009) Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. J Clin Oncol 27(22):3584–3590. doi:10.1200/jco.2008.20.1293

    Article  CAS  PubMed  Google Scholar 

  85. Choueiri TK, Plantade A, Elson P, et al. (2008) Efficacy of sunitinib and sorafenib in metastatic papillary and chromophobe renal cell carcinoma. J Clin Oncol 26(1):127–131. doi:10.1200/jco.2007.13.3223

    Article  CAS  PubMed  Google Scholar 

  86. Kerbel RS (2008) Tumor angiogenesis. N Engl J Med 358(19):2039–2049. doi:10.1056/NEJMra0706596

    Article  CAS  PubMed  Google Scholar 

  87. Rixe O, Bukowski RM, Michaelson MD, et al. (2007) Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: a phase II study. Lancet Oncol 8(11):975–984. doi:10.1016/s1470-2045(07)70285-1

    Article  PubMed  Google Scholar 

  88. Brugarolas J (2007) Renal-cell carcinoma—molecular pathways and therapies. N Engl J Med 356(2):185–187. doi:10.1056/NEJMe068263

    Article  CAS  PubMed  Google Scholar 

  89. Escudier B, Bellmunt J, Negrier S, et al. (2010) Phase III trial of bevacizumab plus interferon alfa-2a in patients with metastatic renal cell carcinoma (AVOREN): final analysis of overall survival. J Clin Oncol 28(13):2144–2150. doi:10.1200/jco.2009.26.7849

    Article  CAS  PubMed  Google Scholar 

  90. Eisenhauer EA, Therasse P, Bogaerts J et al (2009) New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer 45(2):228–247. doi:10.1016/j.ejca.2008.10.026

    Google Scholar 

  91. Therasse P, Arbuck SG, Eisenhauer EA, et al. (2000) New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst 92(3):205–216

    Article  CAS  PubMed  Google Scholar 

  92. van der Veldt AA, Meijerink MR, van den Eertwegh AJ, Haanen JB, Boven E (2010) Choi response criteria for early prediction of clinical outcome in patients with metastatic renal cell cancer treated with sunitinib. Br J Cancer 102(5):803–809. doi:10.1038/sj.bjc.6605567

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  93. Thiam R, Fournier LS, Trinquart L, et al. (2010) Optimizing the size variation threshold for the CT evaluation of response in metastatic renal cell carcinoma treated with sunitinib. Ann Oncol 21(5):936–941. doi:10.1093/annonc/mdp466

    Article  CAS  PubMed  Google Scholar 

  94. Donovan SM, Lonnerdal B (1989) Development of a human milk protein standard. Acta Paediatr Scand 78(2):171–179

    Article  CAS  PubMed  Google Scholar 

  95. Benjamin RS, Choi H, Macapinlac HA, et al. (2007) We should desist using RECIST, at least in GIST. J Clin Oncol 25(13):1760–1764. doi:10.1200/jco.2006.07.3411

    Article  PubMed  Google Scholar 

  96. Nathan PD, Vinayan A, Stott D, Juttla J, Goh V (2010) CT response assessment combining reduction in both size and arterial phase density correlates with time to progression in metastatic renal cancer patients treated with targeted therapies. Cancer Biol Ther 9(1):15–19

    Article  PubMed  Google Scholar 

  97. Smith AD, Lieber ML, Shah SN (2010) Assessing tumor response and detecting recurrence in metastatic renal cell carcinoma on targeted therapy: importance of size and attenuation on contrast-enhanced CT. AJR Am J Roentgenol 194(1):157–165. doi:10.2214/ajr.09.2941

    Article  PubMed  Google Scholar 

  98. Smith AD, Shah SN, Rini BI, Lieber ML, Remer EM (2010) Morphology, attenuation, size, and structure (MASS) criteria: assessing response and predicting clinical outcome in metastatic renal cell carcinoma on antiangiogenic targeted therapy. AJR Am J Roentgenol 194(6):1470–1478. doi:10.2214/ajr.09.3456

    Article  PubMed  Google Scholar 

  99. Wang JH, Min PQ, Wang PJ, et al. (2006) Dynamic CT evaluation of tumor vascularity in renal cell carcinoma. AJR Am J Roentgenol 186(5):1423–1430. doi:10.2214/ajr.04.1408

    Article  PubMed  Google Scholar 

  100. Jackson A, O’Connor JP, Parker GJ, Jayson GC (2007) Imaging tumor vascular heterogeneity and angiogenesis using dynamic contrast-enhanced magnetic resonance imaging. Clin Cancer Res 13(12):3449–3459. doi:10.1158/1078-0432.ccr-07-0238

    Article  PubMed  Google Scholar 

  101. de Bazelaire C, Alsop DC, George D, et al. (2008) Magnetic resonance imaging-measured blood flow change after antiangiogenic therapy with PTK787/ZK 222584 correlates with clinical outcome in metastatic renal cell carcinoma. Clin Cancer Res 14(17):5548–5554. doi:10.1158/1078-0432.ccr-08-0417

    Article  PubMed  Google Scholar 

  102. Sandrasegaran K, Sundaram CP, Ramaswamy R, et al. (2010) Usefulness of diffusion-weighted imaging in the evaluation of renal masses. AJR Am J Roentgenol 194(2):438–445. doi:10.2214/ajr.09.3024

    Article  PubMed  Google Scholar 

  103. Lassau N, Koscielny S, Albiges L, et al. (2010) Metastatic renal cell carcinoma treated with sunitinib: early evaluation of treatment response using dynamic contrast-enhanced ultrasonography. Clin Cancer Res 16(4):1216–1225. doi:10.1158/1078-0432.ccr-09-2175

    Article  CAS  PubMed  Google Scholar 

  104. Wang XH, Wang YJ, Lei CG (2011) Evaluating the perfusion of occupying lesions of kidney and bladder with contrast-enhanced ultrasound. Clin Imaging 35(6):447–451. doi:10.1016/j.clinimag.2010.11.001

    Article  PubMed  Google Scholar 

  105. Khandani AH, Rathmell WK (2012) Positron emission tomography in renal cell carcinoma: an imaging biomarker in development. Semin Nucl Med 42(4):221–230. doi:10.1053/j.semnuclmed.2012.02.002

    PubMed  Google Scholar 

  106. Chen W, Delaloye S, Silverman DH, et al. (2007) Predicting treatment response of malignant gliomas to bevacizumab and irinotecan by imaging proliferation with [18F] fluorothymidine positron emission tomography: a pilot study. J Clin Oncol 25(30):4714–4721. doi:10.1200/jco.2006.10.5825

    Article  CAS  PubMed  Google Scholar 

  107. Anderson H, Yap JT, Wells P, et al. (2003) Measurement of renal tumour and normal tissue perfusion using positron emission tomography in a phase II clinical trial of razoxane. Br J Cancer 89(2):262–267. doi:10.1038/sj.bjc.6601105

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  108. Schwarzenberg J, Czernin J, Cloughesy TF, et al. (2012) 3’-deoxy-3’-18F-fluorothymidine PET and MRI for early survival predictions in patients with recurrent malignant glioma treated with bevacizumab. J Nucl Med 53(1):29–36. doi:10.2967/jnumed.111.092387

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  109. Ganeshan DM, Salem U, Viswanathan C, et al. (2013) Complications of oncologic therapy in the abdomen and pelvis: a review. Abdom Imaging 38(1):1–21. doi:10.1007/s00261-012-9899-x

    Article  PubMed  Google Scholar 

  110. Eisen T, Sternberg CN, Robert C, et al. (2012) Targeted therapies for renal cell carcinoma: review of adverse event management strategies. J Natl Cancer Inst 104(2):93–113. doi:10.1093/jnci/djr511

    Article  CAS  PubMed  Google Scholar 

  111. Viswanathan C, Bhosale P, Ganeshan DM, et al. (2012) Imaging of complications of oncological therapy in the gastrointestinal system. Cancer Imaging 12:163–172. doi:10.1102/1470-7330.2012.0014

    PubMed  Google Scholar 

  112. Chae EJ, Kim JK, Kim SH, Bae SJ, Cho KS (2005) Renal cell carcinoma: analysis of postoperative recurrence patterns. Radiology 234(1):189–196. doi:10.1148/radiol.2341031733

    Article  PubMed  Google Scholar 

  113. Hafez KS, Novick AC, Campbell SC (1997) Patterns of tumor recurrence and guidelines for followup after nephron sparing surgery for sporadic renal cell carcinoma. J Urol 157(6):2067–2070

    Article  CAS  PubMed  Google Scholar 

  114. Saidi JA, Newhouse JH, Sawczuk IS (1998) Radiologic follow-up of patients with T1-3a, b, c or T4N+M0 renal cell carcinoma after radical nephrectomy. Urology 52(6):1000–1003

    Article  CAS  PubMed  Google Scholar 

  115. Patel U, Sokhi H (2012) Imaging in the follow-up of renal cell carcinoma. AJR Am J Roentgenol 198(6):1266–1276. doi:10.2214/ajr.11.8381

    Article  PubMed  Google Scholar 

  116. Skolarikos A, Alivizatos G, Laguna P, de la Rosette J (2007) A review on follow-up strategies for renal cell carcinoma after nephrectomy. Eur Urol 51(6):1490–1500; discussion 1501. doi:10.1016/j.eururo.2006.12.031

    Google Scholar 

  117. Klatte T, Lam JS, Shuch B, Belldegrun AS, Pantuck AJ (2008) Surveillance for renal cell carcinoma: why and how? When and how often? Urol Oncol 26(5):550–554. doi:10.1016/j.urolonc.2007.05.026

    Article  PubMed  Google Scholar 

  118. Lane BR, Gill IS (2007) 5-year outcomes of laparoscopic partial nephrectomy. J Urol 177(1):70–74; discussion 74. doi:10.1016/j.juro.2006.08.093

    Google Scholar 

  119. Rabinovitch RA, Zelefsky MJ, Gaynor JJ, Fuks Z (1994) Patterns of failure following surgical resection of renal cell carcinoma: implications for adjuvant local and systemic therapy. J Clin Oncol 12(1):206–212

    CAS  PubMed  Google Scholar 

  120. Russo P (2010) Partial nephrectomy for renal cancer: part I. BJU Int 105(9):1206–1220. doi:10.1111/j.1464-410X.2010.09339.x

    Article  PubMed  Google Scholar 

  121. Lam JS, Shvarts O, Leppert JT et al (2005) Postoperative surveillance protocol for patients with localized and locally advanced renal cell carcinoma based on a validated prognostic nomogram and risk group stratification system. J Urol 174(2):466–472; discussion 472; quiz 801. doi:10.1097/01.ju.0000165572.38887.da

    Google Scholar 

  122. Nguyen CT, Lane BR, Kaouk JH et al (2008) Surgical salvage of renal cell carcinoma recurrence after thermal ablative therapy. J Urol 180(1):104–109; discussion 109. doi:10.1016/j.juro.2008.03.046

    Google Scholar 

  123. Thumar AB, Trabulsi EJ, Lallas CD, Brown DB (2010) Thermal ablation of renal cell carcinoma: triage, treatment, and follow-up. JVIR 21(8 Suppl):S233–S241. doi:10.1016/j.jvir.2010.01.050

    Article  PubMed  Google Scholar 

  124. Zagoria RJ, Pettus JA, Rogers M, et al. (2011) Long-term outcomes after percutaneous radiofrequency ablation for renal cell carcinoma. Urology 77(6):1393–1397. doi:10.1016/j.urology.2010.12.077

    Article  PubMed  Google Scholar 

  125. Clark TW, Millward SF, Gervais DA, et al. (2009) Reporting standards for percutaneous thermal ablation of renal cell carcinoma. JVIR 20(7 Suppl):S409–S416. doi:10.1016/j.jvir.2009.04.013

    Article  PubMed  Google Scholar 

  126. Kunkle DA, Kutikov A, Uzzo RG (2009) Management of small renal masses. Semin Ultrasound CT MR 30(4):352–358

    Article  PubMed  Google Scholar 

  127. Janzen NK, Kim HL, Figlin RA, Belldegrun AS (2003) Surveillance after radical or partial nephrectomy for localized renal cell carcinoma and management of recurrent disease. Urol Clin North Am 30(4):843–852

    Article  PubMed  Google Scholar 

  128. Cozzoli A, Milano S, Cancarini G, Zanotelli T, Cosciani Cunico S (1995) Surgery of lung metastases in renal cell carcinoma. Br J Urol 75(4):445–447

    Article  CAS  PubMed  Google Scholar 

  129. Ritchie AW, Chisholm GD (1983) The natural history of renal carcinoma. Semin Oncol 10(4):390–400

    CAS  PubMed  Google Scholar 

  130. Ng CS, Loyer EM, Iyer RB, et al. (1999) Metastases to the pancreas from renal cell carcinoma: findings on three-phase contrast-enhanced helical CT. AJR Am J Roentgenol 172(6):1555–1559. doi:10.2214/ajr.172.6.10350288

    Article  CAS  PubMed  Google Scholar 

  131. Griffin N, Gore ME, Sohaib SA (2007) Imaging in metastatic renal cell carcinoma. AJR Am J Roentgenol 189(2):360–370. doi:10.2214/ajr.07.2077

    Article  PubMed  Google Scholar 

  132. Jain Y, Liew S, Taylor MB, Bonington SC (2011) Is dual-phase abdominal CT necessary for the optimal detection of metastases from renal cell carcinoma? Clin Radiol 66(11):1055–1059. doi:10.1016/j.crad.2011.06.002

    Article  CAS  PubMed  Google Scholar 

  133. Sohaib SA, Cook G, Allen SD, et al. (2009) Comparison of whole-body MRI and bone scintigraphy in the detection of bone metastases in renal cancer. Br J Radiol 82(980):632–639. doi:10.1259/bjr/52773262

    Article  CAS  PubMed  Google Scholar 

  134. Kang DE, White RLJr, Zuger JH, Sasser HC, Teigland CM (2004) Clinical use of fluorodeoxyglucose F 18 positron emission tomography for detection of renal cell carcinoma. J Urol 171(5):1806–1809. doi:10.1097/01.ju.0000120241.50061.e4

    Article  PubMed  Google Scholar 

  135. Park JW, Jo MK, Lee HM (2009) Significance of 18F-fluorodeoxyglucose positron-emission tomography/computed tomography for the postoperative surveillance of advanced renal cell carcinoma. BJU Int 103(5):615–619. doi:10.1111/j.1464-410X.2008.08150.x

    Article  PubMed  Google Scholar 

  136. Wang HY, Ding HJ, Chen JH, et al. (2012) Meta-analysis of the diagnostic performance of [18F]FDG-PET and PET/CT in renal cell carcinoma. Cancer Imaging 12:464–474. doi:10.1102/1470-7330.2012.0042

    Article  PubMed  Google Scholar 

  137. Miyao N, Naito S, Ozono S, et al. (2011) Late recurrence of renal cell carcinoma: retrospective and collaborative study of the Japanese Society of Renal Cancer. Urology 77(2):379–384. doi:10.1016/j.urology.2010.07.462

    Article  PubMed  Google Scholar 

  138. Sandock DS, Seftel AD, Resnick MI (1995) A new protocol for the followup of renal cell carcinoma based on pathological stage. J Urol 154(1):28–31

    Article  CAS  PubMed  Google Scholar 

  139. Choyke PL, Glenn GM, Walther MM, Zbar B, Linehan WM (2003) Hereditary renal cancers. Radiology 226(1):33–46

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Dhakshinamoorthy Ganeshan.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ganeshan, D., Morani, A., Ladha, H. et al. Staging, surveillance, and evaluation of response to therapy in renal cell carcinoma: role of MDCT. Abdom Imaging 39, 66–85 (2014). https://doi.org/10.1007/s00261-013-0037-1

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00261-013-0037-1

Keywords

Navigation