Skip to main content

Advertisement

Log in

Extraovarian primary peritoneal carcinoma: staging with 18F-FDG PET/CT

  • Published:
Abdominal Imaging Aims and scope Submit manuscript

Abstract

A 69-year-old woman who presented with left lower quadrant abdominal pain and elevated serum cancer antigen 125 (CA-125) levels was referred for an MRI and an 18F-FDG PET/CT to evaluate a suspicious abdominal mass seen on ultrasound. PET/CT showed extensive, intensely FDG-avid, omental and pelvic peritoneal thickening with no suspicious ovarian or colon masses. Based on the PET/CT results, the patient had extensive debulking surgery and histopathological evaluation revealed an extraovarian primary peritoneal carcinoma (EOPPC). 18F-FDG PET/CT may be useful in differentiating EOPPC from other types of peritoneal carcinomatosis, and in determining the extent of the disease to better guide surgical management and improve long term outcomes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

References

  1. Bhuyan P, Mahapatra S, Mahapatra S, et al. (2010) Extraovarian primary peritoneal papillary serous carcinoma. Arch Gynecol Obstet 281:561–564

    Article  PubMed  Google Scholar 

  2. Turlakow A, Yeung HW, Salmon AS, Macapinlac HA, Larson SM (2003) Peritoneal carcinomatosis: role of 18F-FDG PET. J Nucl Med 44:1407–1412

    PubMed  Google Scholar 

  3. Wang PH, Liu RS, Li YF, Ng HT, Yuan CC (2000) Whole-body PET with (fluorine-18)-2-deoxyglucose for detecting recurrent primary serous peritoneal carcinoma: An initial report. Gynecol Oncol 77:44–47

    Article  PubMed  CAS  Google Scholar 

  4. Rose PG, Faulhaber P, Miraldi F, Abdul-Karim FW (2001) Positive emission tomography for evaluating a complete clinical response in patients with ovarian or peritoneal carcinoma: correlation with second-look laparotomy. Gynecol Oncol 82:17–21

    Article  PubMed  CAS  Google Scholar 

  5. Eltabbakh GH, Werness BA, Piver S, Blumenson LE (1998) Prognostic factors in extraovarian primary peritoneal carcinoma. Gynecol Oncol 71:230–239

    Article  PubMed  CAS  Google Scholar 

  6. Grant DJ, Moorman PG, Akushevich L, et al. (2010) Primary peritoneal and ovarian cancers: an epidemiological comparative analysis. Cancer Causes Control 21:991–998

    Article  PubMed  Google Scholar 

  7. Goodman MT, Shvetsov YB (2009) Rapidly increasing incidence of papillary serous carcinoma of the peritoneum in the United States: fact or artifact? Int J Cancer 124:2231–2235

    Article  PubMed  CAS  Google Scholar 

  8. Muto MG, Welch WR, Mok SC, et al. (1995) Evidence for a multifocal origin of papillary serous carcinoma of the peritoneum. Cancer Res 55:490–492

    PubMed  CAS  Google Scholar 

  9. White CD (1993) Papillary intraperitoneal neoplasia resembling ovarian carcinoma after removal of benign ovaries. W V Med J 89:282–283

    PubMed  CAS  Google Scholar 

  10. Shmueli E (2001) Primary papillary serous carcinoma of the peritoneum in a man. Ann Oncol 12:563–567

    Article  PubMed  CAS  Google Scholar 

  11. Shibata R (2004) Extraovarian primary peritoneal carcinoma in a child. Pediatr Blood Cancer 42:292–293

    Article  PubMed  Google Scholar 

  12. Levine DA, Argenta PA, Yee CJ, et al. (2003) Fallopian tube and primary peritoneal carcinomas associated with BRCA mutations. J Clin Oncol 21:4222–4227

    Article  PubMed  CAS  Google Scholar 

  13. Fromm GL (1990) Papillary serous carcinoma of the peritoneum. Obstet Gynaecol 75:75–89

    Google Scholar 

  14. Eltabbakh GH, Piver MS, Natarajan N, Mettlin CJ (1998) Epidemiologic differences between women with extraovarian primary peritoneal carcinoma and women with epithelial ovarian cancer. Obstet Gynaecol 91:254–259

    Article  CAS  Google Scholar 

  15. Dalrymple JC, Bannatyne P, Russell P, et al. (1989) Extraovarian peritoneal serous papillary carcinoma: a clinicopathologic study of 31 cases. Cancer 64:110–115

    Article  PubMed  CAS  Google Scholar 

  16. Alvarez JV, Gomez MM, Prats MDG, et al. (2007) Extraovarian primary peritoneal carcinoma: a case report. Rev Esp Patol 40:47–52

    Google Scholar 

  17. Levy AD, Arnaiz J, Shaw JC, Sobin LH (2008) Primary peritoneal tumors: imaging features with pathologic correlation. Radiographics 28:583–607

    Article  PubMed  Google Scholar 

  18. Stafford-Johnson DB, Bree RL, Francis IR, Korobkin M (1998) CT appearance of primary papillary serous carcinoma of the peritoneum. AJR Am J Roentgenol 171:687–689

    PubMed  CAS  Google Scholar 

  19. Chopra S, Laurie LR, Chintapalli KN, et al. (2000) Primary papillary serous carcinoma of the peritoneum: CT-pathologic correlation. J Comput Assist Tomogr 24:395–399

    Article  PubMed  CAS  Google Scholar 

  20. Gryspeerdt S, Clabout L, Van Hoe L, Berteloot P, Vergote IB (1998) Intraperitoneal contrast material combined with CT for detection of peritoneal metastases of ovarian cancer. Eur J Gynaecol Oncol 19:434–437

    PubMed  CAS  Google Scholar 

  21. Raptopoulos V, Gourtsoyiannis N (2001) Peritoneal carcinomatosis. Eur Radiol 11:2195–2206

    Article  PubMed  CAS  Google Scholar 

  22. Low RN (1997) Peritoneal tumor: MR imaging with dilute oral barium and intravenous gadolinium containing contrast agents compared with unenhanced MR imaging and CT. Radiology 204:513–520

    PubMed  CAS  Google Scholar 

  23. Ricke J, Sehoule J, Hosten N, et al. (1999) Fat-saturated, contrast-enhanced spin-echo sequences in the magnetic resonance tomographic diagnosis of peritoneal carcinosis [in German]. Rofo 171:461–467

    Article  PubMed  CAS  Google Scholar 

  24. Choi CH, Kim TJ, Kim WY, et al. (2007) Papillary serous carcinoma in ovaries of normal size: a clinicopathologic study of 20 cases and comparison with extraovarian peritoneal papillary serous carcinoma. Gynecol Oncol 105:762–768

    Article  PubMed  Google Scholar 

  25. Dirisamer A, Schima W, Heinisch M, et al. (2009) Detection of histologically proven peritoneal carcinomatosis with fused 18F-FDG PET/MDCT. Eur J Radiol 69:536–541

    Article  PubMed  Google Scholar 

  26. De Gaetano AM, Calcagni ML, Rufini V, et al. (2009) Imaging of peritoneal carcinomatosis with FDG PET-CT: diagnostic patterns, case examples and pitfalls. Abdom Imag 34:391–402

    Article  Google Scholar 

  27. Dromain C, Leboulleux S, Auperin A, et al. (2008) Staging of peritoneal carcinomatosis: enhanced CT vs PET/CT. Abdom Imag 33:87–93

    Article  Google Scholar 

  28. Suzuki A, Kawano T, Takahashi N, et al. (2004) Value of 18F-FDG PET in the detection of peritoneal carcinomatosis. Eur J Nucl Med Mol Imag 31:1413–1420

    Article  Google Scholar 

  29. Kim CK, Park BK, Choi JY, Kim JH (2009) Comparison of the MRI and integrated PET/CT findings in the preoperative detection of peritoneal carcinomatosis arising from primary ovarian cancer. J Korean Soc Radiol 60:117–126

    Google Scholar 

  30. Funicelli L, Travaini LL, Landoni F, et al. (2010) Peritoneal carcinomatosis from ovarian cancer: the role of CT and [(18F)]FDG-PET/CT. Abdom Imag 35:701–707

    Article  CAS  Google Scholar 

  31. Lloyd GM, Neal CP, Da Forno PD, West K, Miller AS (2010) Metastatic primary peritoneal carcinoma: an unexpected finding on histological examination of haemorrhoids. Colorectal Dis 12:602–603

    Article  PubMed  CAS  Google Scholar 

  32. Eltabbakh GH, Piver MS, Hempling RE, Werness BA, Blumenson LE (1998) Importance of lymph node metastases in primary peritoneal carcinoma. J Surg Oncol 68:144–148

    Article  PubMed  CAS  Google Scholar 

  33. Eltabbakh GH, Piver MS, Werness BA (1997) Primary peritoneal adenocarcinoma metastatic to the brain. Gynecol Oncol 66:160–163

    Article  PubMed  CAS  Google Scholar 

  34. Piver MS, Eltabbakh GH, Hempling RE, Recio FO, Blumenson LE (1997) Two sequential studies for primary peritoneal carcinoma: induction with weekly cisplatin followed by either cisplatin-doxorubicin-cyclophosphamide or paclitaxel-cisplatin. Gynecol Oncol 67:141–146

    Article  PubMed  CAS  Google Scholar 

  35. Gunn AJ, Brechbiel MW, Choyke PL (2007) The emerging role of molecular imaging and targeted therapeutics in peritoneal carcinomatosis. Expert Opin Drug Deliv 4:389–402

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to William Makis.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rakheja, R., Makis, W. & Hickeson, M. Extraovarian primary peritoneal carcinoma: staging with 18F-FDG PET/CT. Abdom Imaging 37, 304–308 (2012). https://doi.org/10.1007/s00261-011-9722-0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00261-011-9722-0

Keywords

Navigation