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Hemodynamic alterations in anterior segment of liver graft after right-lobe living-donor liver transplantation: computed tomography perfusion imaging findings

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Abstract

Background

To identify hemodynamic alterations in anterior segment of liver graft after living-donor liver transplantation (LDLT) using CT perfusion imaging.

Methods

Perfusion images of 19 recipients 4 weeks after LDLT without reconstruction of the middle hepatic vein (MHV) tributaries were retrospectively identified. According to major MHV tributaries diameter in the right lobe graft, recipients were divided into large (≥5 mm) and small size groups (<5 mm). Blood flow (BF), blood volume (BV), and mean transit time (MTT) of anterior and posterior segments were calculated.

Results

In large size group, significantly decreased BF (66.98 ± 15.79 mL/min/100 g, corresponded to 37.08%), BV (8.27 ± 2.29 mL/100 g, 41.71%), and increased MTT (11.79 ± 2.10 s, 23.71%) were detected in the anterior segment compared to the posterior segment. In small size group, compared to the posterior segment, BF, BV in the anterior segment decreased 19.12%, 18.48%, respectively, and MTT increased 6.78%, where decreased BF (86.40 ± 21.39 mL/min/100 g) and BV (11.50 ± 2.59 mL/min/100 g) reached statistical significance. Perfusion imbalance in large size group was more remarkable than those in small size group.

Conclusions

CT liver perfusion imaging enabled quantification of hemodynamic alterations in right-lobe liver graft after LDLT. Compared to small ones, ligation of large MHV tributaries could bring about more marked perfusion imbalance between anterior and posterior segments.

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Abbreviations

LDLT:

Living-donor liver transplantation

CT:

Computed tomography

MHV:

Middle hepatic vein

RHV:

Right hepatic vein

MRI:

Magnetic resonance imaging

ROI:

Region of interest

BF:

Blood flow

BV:

Blood volume

MTT:

Mean transit time

GRWR:

Graft-to-recipient weight ratio

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Acknowledgment

Supported partly by the Chinese National Natural Science Foundation under Grant 30770608.

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Authors and Affiliations

  1. Department of Radiology, Renji Hospital, Shanghai Jiaotong University School of Medicine, 1630, Dongfang Rd., Pudong, Shanghai, 200127, People’s Republic of China

    Li Jun Qian, Zhi Guo Zhuang & Jian Rong Xu

  2. Department of Diagnostic Radiology, Liver Transplantation Program, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, 83305, Taiwan

    Yu Fan Cheng

  3. Center of Organ Transplantation, Renji Hospital, Shanghai Jiaotong University School of Medicine, 1630, Dongfang Rd., Pudong, Shanghai, 200127, People’s Republic of China

    Qiang Xia & Jian Jun Zhang

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  1. Li Jun Qian
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  2. Zhi Guo Zhuang
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  3. Yu Fan Cheng
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  4. Qiang Xia
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  5. Jian Jun Zhang
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Correspondence to Jian Rong Xu.

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Qian, L.J., Zhuang, Z.G., Cheng, Y.F. et al. Hemodynamic alterations in anterior segment of liver graft after right-lobe living-donor liver transplantation: computed tomography perfusion imaging findings. Abdom Imaging 35, 522–527 (2010). https://doi.org/10.1007/s00261-009-9563-2

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  • DOI: https://doi.org/10.1007/s00261-009-9563-2

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