Skip to main content

Advertisement

Log in

Hepatic adenomas associated with anti-epileptic drugs: a case series and imaging review

  • Published:
Abdominal Imaging Aims and scope Submit manuscript

Abstract

We report four patients on long-term antiepileptic drugs, without any history of anabolic steroid or oral contraceptive use, who had path-proven hepatic adenomas at our institution. Imaging review of one case is presented here. An exhaustive literature search reveals only four other such case reports, none from the North American continent.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4

References

  1. Chabicovsky M, Wastl U, Taper H, et al. (2003) Induction of apoptosis in mouse liver adenoma and carcinoma in vivo by transforming growth factor-beta1. J Cancer Res Clin Oncol 129(9):536–542

    Article  CAS  PubMed  Google Scholar 

  2. Weghorst CM, Devor DE, Henneman JR, Ward JM (1994) Promotion of hepatocellular foci and adenomas by di(2-ethylhexyl) phthalate and phenobarbital in C3H/HeNCr mice following exposure to N-nitrosodiethylamine at 15 days of age. Exp Toxicol Pathol 45(7):423–431

    CAS  PubMed  Google Scholar 

  3. Vazquez JJ, Marigil MA (1989) Liver-cell adenoma in an epileptic man on barbiturates. Histol Histopathol 4(3):301–303

    CAS  PubMed  Google Scholar 

  4. Ferko A, Bedrna J, Nozicka J (2003) Pigmented hepatocellular adenoma of the liver caused by long-term use of phenobarbital. Rozhl Chir 82(4):192–195

    CAS  PubMed  Google Scholar 

  5. Tazawa K, Yasuda M, Ohtani Y, Makuuchi H, Osamura RY (1999) Multiple hepatocellular adenomas associated with long-term carbamazepine. Histopathology 35(1):92–94

    Article  CAS  PubMed  Google Scholar 

  6. Seki A, Inoue T, Maegaki Y, et al. (2006) Polycystic ovary syndrome and hepatocellular adenoma related to long-term use of sodium valproate in a young woman. No to Hattatsu (Brain Dev) 38(3):205–208

    Google Scholar 

  7. Carrasco D, Prieto M, Pallardo L, et al. (1985) Multiple hepatic adenomas after long-term therapy with testosterone enanthate. Review of the literature. J Hepatol 1(6):573–578

    Article  CAS  PubMed  Google Scholar 

  8. Grazioli L, Morana G, Kirchin M, Schneider G (2005) Accurate differentiation of focal nodular hyperplasia from hepatic adenoma at gadobenate dimeglumine-enhanced MR imaging: prospective study. Radiology 236(1):166–177

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Christine U. Lee.

Additional information

The work described in this manuscript was all done at Mayo Clinic, Rochester, MN. All the authors have taken an active role in the data search and review as well as in the manuscript preparation.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lee, P.U.Y., Roberts, L.R., Kaiya, J.K. et al. Hepatic adenomas associated with anti-epileptic drugs: a case series and imaging review. Abdom Imaging 35, 208–211 (2010). https://doi.org/10.1007/s00261-009-9500-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00261-009-9500-4

Keywords

Navigation