Abstract
We report four patients on long-term antiepileptic drugs, without any history of anabolic steroid or oral contraceptive use, who had path-proven hepatic adenomas at our institution. Imaging review of one case is presented here. An exhaustive literature search reveals only four other such case reports, none from the North American continent.
References
Chabicovsky M, Wastl U, Taper H, et al. (2003) Induction of apoptosis in mouse liver adenoma and carcinoma in vivo by transforming growth factor-beta1. J Cancer Res Clin Oncol 129(9):536–542
Weghorst CM, Devor DE, Henneman JR, Ward JM (1994) Promotion of hepatocellular foci and adenomas by di(2-ethylhexyl) phthalate and phenobarbital in C3H/HeNCr mice following exposure to N-nitrosodiethylamine at 15 days of age. Exp Toxicol Pathol 45(7):423–431
Vazquez JJ, Marigil MA (1989) Liver-cell adenoma in an epileptic man on barbiturates. Histol Histopathol 4(3):301–303
Ferko A, Bedrna J, Nozicka J (2003) Pigmented hepatocellular adenoma of the liver caused by long-term use of phenobarbital. Rozhl Chir 82(4):192–195
Tazawa K, Yasuda M, Ohtani Y, Makuuchi H, Osamura RY (1999) Multiple hepatocellular adenomas associated with long-term carbamazepine. Histopathology 35(1):92–94
Seki A, Inoue T, Maegaki Y, et al. (2006) Polycystic ovary syndrome and hepatocellular adenoma related to long-term use of sodium valproate in a young woman. No to Hattatsu (Brain Dev) 38(3):205–208
Carrasco D, Prieto M, Pallardo L, et al. (1985) Multiple hepatic adenomas after long-term therapy with testosterone enanthate. Review of the literature. J Hepatol 1(6):573–578
Grazioli L, Morana G, Kirchin M, Schneider G (2005) Accurate differentiation of focal nodular hyperplasia from hepatic adenoma at gadobenate dimeglumine-enhanced MR imaging: prospective study. Radiology 236(1):166–177
Author information
Authors and Affiliations
Corresponding author
Additional information
The work described in this manuscript was all done at Mayo Clinic, Rochester, MN. All the authors have taken an active role in the data search and review as well as in the manuscript preparation.
Rights and permissions
About this article
Cite this article
Lee, P.U.Y., Roberts, L.R., Kaiya, J.K. et al. Hepatic adenomas associated with anti-epileptic drugs: a case series and imaging review. Abdom Imaging 35, 208–211 (2010). https://doi.org/10.1007/s00261-009-9500-4
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00261-009-9500-4