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RETRACTED ARTICLE: Diagnosis of rejection after liver transplantation: use of phosphorus-31 magnetic resonance spectroscopy (31P-MRS)

Abdominal Radiology volume 37, pages 788–794 (2012)Cite this article

An Erratum to this article was published on 30 May 2016

Abstract

Background

In vivo hepatic phosphorus-31 magnetic resonance spectroscopy (31P-MRS) provides non-invasive information about phospholipid metabolism. Aims: To delineate 31P-MRS abnormalities in patients with chronic rejection and to charactererize spectral changes by pathology.

Patients and methods

Sixty-six liver transplant recipients (18 with chronic rejection and 48 with normal graft function) and 38 controls (23 healthy volunteers and fifteen patients with biliary duct stricture) were studied with in vivo 31P-MRS. All the data and peak values were calibrated and calculated by the software of spectroscopy analysis GE, and the pH values were calculated by the Malloy’s formula, then the peak area ratios and altitudes of metabolites relative to adenosine triphosphate (β-ATP)and phosphate (Pi) were measured.

Results

(a) The peak area ratios and altitudes of PME and PDE in biliary duct stricture group and chronic rejection group were higher than those of healthy volunteer group and normal graft function group. Patients with chronic rejection had significant differences in the peak area ratios of PME: β-ATP (P < 0.05) and PDE: β-ATP (P < 0.05) and in the altitudes of PME: β-ATP (P < 0.05) as compared with the other groups. (b) The ratios of β-ATP/Pi decreased in biliary duct stricture group, while they increased in chronic rejection group. There was no difference between the four groups. There were similar changes in the ratios of PME/Pi, but there was significant difference between the chronic rejection group and the other three groups. (c) pH values increased in biliary duct stricture group and chronic rejection group, though the difference was not significant with the healthy control group. (d) Histological specimens showed focal loss of hepatocytes, degeneration, and hepatocytic atrophy.

Conclusions

31P-MRS imaging is valuable in detecting the metabolism of the liver after transplantation, and suggests that further investigation of alterations in the phospholipid metabolism may be a useful future direction of research.

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References

  1. Noack KB, Wiesner RH, Batts K et al. (1991) Severe ductopenic rejection with features of vanishing bile duct syndrome:clinical,biochemical and histological evidence for spontaneous resolution. Transplant Proc 23:1448–1451

    CAS  PubMed  Google Scholar 

  2. Wiesner RH, Ludwig J, Krom RAF et al. (1993) Hepatic allograft rejection:new developments in terminology,diagnosis,precention and treatment. Mayo Clin Proc 68:69–79

    CAS  Article  PubMed  Google Scholar 

  3. Oberhaensli R, Rajagopalan B, Galloway GJ et al. (1990) Study of human liver disease with P-31 magnetic resonance spectroscopy. Gut 31:463–467

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  4. Munakata T, Griffiths RD, Martin PA et al. (1993) An in vivo 31PMRS study of patients with liver cirrhosis: progress towards a non-invasive assessment of disease severity. NMR Biomed 6:168–172

    CAS  Article  PubMed  Google Scholar 

  5. Menon DK, Sargentoni J, Taylor-Robinson SD et al. (1995) Effect of functional grade and etiology on in vivo hepatic phosphorus-31 magnetic resonance spectroscopy in cirrhosis: biochemical basis of spectral appearances. Hepatology 21:417–427

    CAS  PubMed  Google Scholar 

  6. Taylor-Robinson SD, Thomas EL, Sargentoni J et al. (1995) Cirrhosis of the human liver: An in vitro 31P nuclear magnetic resonance study. Biochim Biophys Acta 1272:113–118

    Article  PubMed  Google Scholar 

  7. European FK506 multicenter liver study group. (1994) Randomised trial comparing tacrolimus(FK506) and cyclosporine in prevention of liver allograft rejection. Lancet 344:423–428

    Article  Google Scholar 

  8. Malloy CR, Cunningham CC, Radda CK (1986) The metabolic state of the rat liver in vivo measured by 31P-NMR spectroscopy. Biochim Biopys Acta 885:1

    CAS  Article  Google Scholar 

  9. Uberbaenshi RD, Galloway GJ, Taylor LJ et al. (1986) Assessment of human liver metabolism by phosphorus-31 magnetic resonance spectroscopy. Br J Radiol 59:695

    Article  Google Scholar 

  10. Tang ZQ, Zhu SN, Cao SL et al. (1993) Modern Oncology. Shanghai Medical university publishing house, Shanghai, pp 47–50

    Google Scholar 

  11. Ruiz-Cabello J, Cohen JS (1992) Phospholipid metabolites as indicators of cancer cell function. NMR Biomed 5:226–233

    CAS  Article  PubMed  Google Scholar 

  12. Taylor-Robinson SD,Sargentoni J,Bell JD et al. (1998) In vivo and in vitro hepatic phosphorus-31 magnetic resonance spectroscopy and electron microscopy in chronic ductopenic rejection of human liver allografts. Gut 42:735–743

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  13. Murphy EJ, Brindle KM, Rorison CJ et al. (1992) Changes in phosphatidylethanolamine metabolism in regenerating rat liver as measured by P-31 NMR. Biochem Biophys Acta 1135:27–34

    CAS  Article  PubMed  Google Scholar 

  14. Taylor-Robinson SD,Sargentoni J, Bell JD et al. (1997) In vivo and in vitro hepatic phosphorus-31 magnetic resonance spectroscopy and electron microscopy of the cirrhotic liver. Liver 17:198–209

    CAS  Article  PubMed  Google Scholar 

  15. Murphy EJ, Rajagopalan B, Brindle KM et al. (1989) Phospholipid bilayer contribution to 31P-NMR spectro in vivo. Magn Reson Med 12:282–289

    CAS  Article  PubMed  Google Scholar 

  16. Mann DV, Lam WWM, Magnus HN et al. (2002) Biliary drainage for obstructive jaundice enhances hepatic energy status in humans: a phosphorus-31 magnetic resonance spectroscopy study. Gut 50:118–122

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  17. Shinkwin MA, Lenkmask PE, Daly JM et al. (1991) Integrated magnetic resonance imaging and phosphorus spectroscopy of soft tissue tumors. Cancer 67:1849–1858

    CAS  Article  PubMed  Google Scholar 

  18. Oberhaensli RD, Bore PJ, Rampling RP et al. (1998) Biochemical investigation of human tumors in vivo with phosphorus-31 magnetic resonance spectroscopy. Lancet 5:8–11

    Google Scholar 

  19. Ng TC, Majory AW, Vijayakumar S et al. (1989) Human neoplasm pH and response to radiation therapy: 31P MR spectroscopy studies in situ. Radiology170:875–878

    CAS  Article  PubMed  Google Scholar 

  20. Rubin R, Munoz SJ (1993) Clinicopathologic features of late hepatic dysfunction in orthotopic liver transplants. Hum Pathol 24:643–651

    CAS  Article  PubMed  Google Scholar 

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Affiliations

  1. Department of Radiology, Changzheng Hospital, The Second Military Medical University, Feng Yang Road 415, Shanghai, China

    Tao Jiang, Shiyuan Liu, XiangSheng Xiao, XiaoFeng Tao, GuangHua Liu & JinLin Wang

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  1. Tao Jiang
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  2. Shiyuan Liu
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  3. XiangSheng Xiao
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  4. XiaoFeng Tao
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  5. GuangHua Liu
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Corresponding author

Correspondence to Shiyuan Liu.

Additional information

The Editor-in-Chief is retracting the article "Diagnosis of rejection after liver transplantation: Use of phosphorus-31 magnetic resonance spectroscopy (31P-MRS)" Abdominal Imaging (2012) 37: 788-794, DOI 10.1007/s00261-008-9451-1 because it contains information that was taken from an earlier published article in another journal ("In vivo and in vitro hepatic phosphorus-31 magnetic resonance spectroscopy and electron microscopy in chronic ductopenic rejection of human liver allografts" Gut (1998) 42: 735-43, DOI 10.1136/gut.42.5.735). Please note that - as of January 2016 - the journal name was changed from Abdominal Imaging to Abdominal Radiology.

An erratum to this article is available athttp://dx.doi.org/10.1007/s00261-016-0766-z.

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Jiang, T., Liu, S., Xiao, X. et al. RETRACTED ARTICLE: Diagnosis of rejection after liver transplantation: use of phosphorus-31 magnetic resonance spectroscopy (31P-MRS). Abdom Radiol 37, 788–794 (2012). https://doi.org/10.1007/s00261-008-9451-1

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  • DOI: https://doi.org/10.1007/s00261-008-9451-1

Keywords

  • Magnetic resonance spectroscopy
  • Liver transplantation
  • Rejection
  • Energy metabolites
  • Phospholipids
  • In vivo