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Diagnosing cholangiocarcinoma in primary sclerosing cholangitis: an “evidence based radiology” review

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Abstract

Cholangiocarcinoma is a serious but common complication of primary sclerosing cholangitis (PSC) that is often difficult to diagnose. The aim of this study was to conduct an evidence based radiology review of the diagnostic modalities used to identify cholangiocarcinoma in patients with PSC. A systematic review of the current best evidence was carried out and a diagnostic algorithm for cholangiocarcinoma in PSC is proposed.

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References

  1. Rea DJ, Heimbach JK, Rosen CB, et al. (2005) Liver transplantation with neoadjuvant chemoradiation is more effective than resection for hilar cholangiocarcinoma. Ann Surg 242(3):451–458; discussion 458–461

    PubMed  Google Scholar 

  2. Levy C, Lymp J, Angulo P, et al. (2005) The value of serum CA 19–9 in predicting cholangiocarcinoma in patients with primary sclerosing cholangitis. Dig Dis Sci 50(9):1734–1740

    Article  PubMed  CAS  Google Scholar 

  3. Boberg KM, Jebsen P, Clausen OP, et al. (2006) Diagnostic benefit of biliary brush cytology in cholangiocarcinoma in primary sclerosing cholangitis. J Hepatol 45:568–574

    Article  PubMed  Google Scholar 

  4. Furmanczyk PS, Grieco VS, Agoff SN (2005) Biliary brush cytology and the detection of cholangiocarcinoma in primary sclerosing cholangitis. Am J Clin Pathol 124:355–360

    Article  PubMed  Google Scholar 

  5. Moreno Luna LE, Gores GJ (2006) Advances in the diagnosis of cholangiocarcinoma in patients with primary sclerosing cholangitis. Liver Transplant 12:S15–S19

    Article  Google Scholar 

  6. Staunton M (2007) Evidence-based radiology: Steps 1 and 2- asking answerable questions and searching for evidence. Radiology 242(1):23–31

    PubMed  Google Scholar 

  7. Haynes RB (2001) Of studies, syntheses, synopses, and systems: the “4S” evolution of services for finding current best evidence. ACP J Club 134(2):A11–A13

    PubMed  CAS  Google Scholar 

  8. Levels of evidence Oxford Centre for Evidence-Based Medicine Website (2007) http://www.cebm.net/levels_of_evidence.asp. Date Accessed May 5th 2007

  9. Dodd JD (2007) Evidence-based practice in radiology: steps 3 and 4–appraise and apply diagnostic radiology literature. Radiology 242(2):342–354

    PubMed  Google Scholar 

  10. Campbell WL, Ferris JV, Holbert BL, et al. (1998) Biliary tract carcinoma complicating primary sclerosing cholangitis: evaluation with CT, cholangiography, US, and MR imaging. Radiology 207:41–50

    PubMed  CAS  Google Scholar 

  11. Campbell WL, Peterson MS, Federle MP, Siqueira E S, Slivka A, Grazioli L, Ichikawa T, Oliver JH, Kim T, Li W (2001) Using CT and cholangiography to diagnose biliary tract carcinoma complicating primary sclerosing cholangitis. AJR 177(5):1095–1100

    Google Scholar 

  12. Prytz H, Keiding S, Bjornsson E, et al. (2006) Dynamic FDG-PET is useful for detection of cholangiocarcinoma in patients with PSC listed for liver transplantation. Hepatology 44(6):1572–1580

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

The authors wish to thank Dr Dermot Malone, Department of Radiology, St Vincent’s University Hospital, Dublin for his valuable help. S. L. Walker is a Specialist Registrar in Hepatology in the National Liver Unit who learned the EBR techniques with the SVUH EBR Group.

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Authors and Affiliations

  1. National Liver Unit, St. Vincent’s University Hospital, Elm Park, Dublin 4, Ireland

    Sarah L. Walker & P. Aidan McCormick

  2. University College Dublin, Dublin 4, Ireland

    P. Aidan McCormick

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  1. Sarah L. Walker
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  2. P. Aidan McCormick
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Correspondence to Sarah L. Walker.

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Walker, S.L., McCormick, P.A. Diagnosing cholangiocarcinoma in primary sclerosing cholangitis: an “evidence based radiology” review. Abdom Imaging 33, 14–17 (2008). https://doi.org/10.1007/s00261-007-9314-1

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  • DOI: https://doi.org/10.1007/s00261-007-9314-1

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