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Recurrent ovarian granulosa cell tumors: clinical and imaging features

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Abstract

Background

Granulosa cell tumor of the ovary differs from epithelial ovarian tumors in histologic appearance, clinical course and imaging findings. The purpose of this study was to evaluate clinical and imaging features of recurrent ovarian granulosa cell tumors.

Methods

We performed retrospective evaluation of the medical, surgicopathologic records and CT or MR images of 11 patients with pathologically proven recurrent ovarian granulosa cell tumor.

Results

The first recurrence of granulosa cell tumor was diagnosed at between 4 months and 18 years after the initial surgical resection of tumor (mean; 9.7 years). Six patients relapsed after 10 years after initial diagnosis. The recurrent tumors were located in the pelvic cavity alone in three patients, extrapelvic peritoneal cavity alone in two, both pelvic and extrapelvic peritoneal cavity in three, and paraaortic retroperitoneal space in three. The imaging appearances of recurrent masses were variable ranging from solid masses to completely cystic masses.

Conclusion

Recurrent granulosa cell tumor is characterized by late tumor recurrence manifested as a relatively small number of discrete peritoneal or retroperitoneal masses with variable imaging appearances from solid to cystic masses.

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References

  1. Stuart GC, Dawson LM (2003) Update on granulosa cell tumours of the ovary. Curr Opin Obstet Gynecol 15:33–37

    Article  PubMed  Google Scholar 

  2. Schumer ST, Cannistra SA (2003) Granulosa cell tumor of the ovary. J Clin Oncol 21:1180–1189

    Article  PubMed  Google Scholar 

  3. Pautier P, Lhomme C, Culine S, et al. (1997) Adult granulosa-cell tumor of the ovary: a retrospective study of 45 cases. Int J Gynecol Cancer 7:58–65

    Article  PubMed  CAS  Google Scholar 

  4. Crew KD, Cohen MH, Smith DH, et al. (2005) Long natural history of recurrent granulosa cell tumor of the ovary 23 years after initial diagnosis: a case report and review of the literature. Gynecol Oncol 96:235–240

    Article  PubMed  Google Scholar 

  5. MacSweeney JE, King DM (1994) Computed tomography, diagnosis, staging and follow-up of pure granulosa cell tumor of the ovary. Clin Radiol 49:241–245

    Article  PubMed  CAS  Google Scholar 

  6. Kim SH, Kim SH (2002) Granulosa cell tumor of the ovary: common findings and unusual appearances on CT and MR. J Comput Assist Tomogr 26:756–761

    Article  PubMed  Google Scholar 

  7. Coakley FV, Choi PH, Gougoutas CA, et al. (2002) Peritoneal metastases: detection with spiral CT in patients with ovarian cancer. Radiology 223:495–499

    Article  PubMed  Google Scholar 

  8. Outwater EK, Wagner BJ, Mannion C, et al. (1998) Sex cord-stromal and steroid cell tumors of the ovary. Radiographics 18:1523–1546

    PubMed  CAS  Google Scholar 

  9. Stenwig JT, Hazelcamp JT, Beecham JB (1979) Granulosa cell tumors of the ovary. A clinicopathological study of 118 cases with long-term follow-up. Gynecol Oncol 7:136–152

    Article  PubMed  CAS  Google Scholar 

  10. Hines JF, Khalifa MA, Moore JL, et al. (1996) Recurrent granulosa cell tumor of the ovary 37 years after initial diagnosis: a case report and review of the literature. Gynecol Oncol 60:484–488

    Article  PubMed  CAS  Google Scholar 

  11. Lauszus FF, Petersen AC, Greisen J, et al. (2001) Granulosa cell tumor of the ovary: a population-based study of 37 women with stage I disease. Gynecol Oncol 81:456–460

    Article  PubMed  CAS  Google Scholar 

  12. Park CM, Kim SH, Kim SM, et al. (2003) Recurrent ovarian malignancy: patterns and spectrum of imaging findings. Abdom Imaging 28:404–415

    Article  PubMed  CAS  Google Scholar 

  13. Nishino M, Hayakawa K, Minami M, et al. (2003) Primary retroperitoneal neoplasms: CT and MR imaging findings with anatomic and pathologic diagnostic clues. Radiographics 23:45–57

    Article  PubMed  Google Scholar 

  14. Ko SF, Wan YL, Ng SH, et al. (1999) Adult ovarian granulosa cell tumors: spectrum of sonographic and CT findings with pathologic correlation. AJR 172:1227–1233

    PubMed  CAS  Google Scholar 

Download references

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Correspondence to Jae Young Byun.

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Rha, S.E., Oh, S.N., Jung, S.E. et al. Recurrent ovarian granulosa cell tumors: clinical and imaging features. Abdom Imaging 33, 119–125 (2008). https://doi.org/10.1007/s00261-007-9197-1

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  • DOI: https://doi.org/10.1007/s00261-007-9197-1

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