Abstract
Purpose
To establish the additional value of 3D magnetic resonance spectroscopy (3D-MRS) imaging to endorectal MR imaging in the diagnosis of prostrate cancer in the peripheral zone.
Materials and methods
MR imaging and MRS imaging were performed in 79 patients with suspicion of prostate cancer on the basis of digital rectal exploration, transrectal ultrasound and PSA level. All the examinations were performed with 1.5 T MR scan using an endorectal coil (transverse and coronal FSE T2-weighted sequences, axial SE T1-weighted and PRESS 3D CSI). MR examinations have been evaluated by two Radiologists blind of the clinical data in a “per patients” analysis. MR imaging and MRS imaging findings were compared with the result of histological data from radical prostatectomy in 53 patients and biopsy in 17 patients.
Results
Nine patients (11.4%) were excluded because of serious artefacts in the MR spectrum. The reported values of sensitivity, specificity, PPV and NPV for MR imaging alone were respectively 84%, 50%, 76% and 63% (LR+ 1.7; LR− 0.3). Instead the reported values of sensitivity, specificity, PPV and NPV for the combination of MR imaging to MRS imaging were respectively 89%, 79%, 89% and 79% (LR+ 4.28; LR− 0.14). We found an incremental benefit of MRS imaging to MR imaging for tumour diagnosis although these results did not show statistically significant differences.
Conclusions
The MRS imaging improves the accuracy of the endorectal MR imaging in the diagnosis of prostate cancer.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Presti JC, Hricak H, Narayan PA, et al. (1996) Local staging of prostatic carcinoma: comparison of transrectal sonography and endorectal MR imaging. AJR 166:103–108
Jager GJ, Ruijter ET, Van de Kaa CA, et al. (1996) Local staging of prostate cancer with endorectal MR imaging: correlation with histopathology. AJR 166:845–852
Hricak H, White S, Vigneron D, et al. (1994) Carcinoma of the prostate gland: MR imaging with pelvic phased-array coils versus integrated endorectal–pelvic phased-array coils. Radiology 193:703–709
Schiebler M, Schnall MD, Pollack HM, et al. (1993) Current role of MR imaging in the staging of adenocarcinoma of the prostate. Radiology 189:339–352
White S, Hricak H, Forstner R, et al. (1995) Prostate cancer: effect of postbiopsy haemorrhage on interpretation of MR images. Radiology 195:385–390
Quint LE, Van Erp JS, Bland PH, et al. (1991) Carcinoma of the prostate: MR images obtained with body coils do not accurately reflect tumour volume. AJR 156:511–516
Casciani E. Gualdi GF (2006) Prostate cancer: value of magnetic resonance spectroscopy 3D chemical shift imaging. Abdom Imaging (online first)
Kurhanewicz J, Vigneron DB, Hricak H, et al. (1996) Three-dimensional H-1 MR spectroscopic imaging of the in situ human prostate with high (0.24–0.7-cm3) spatial resolution. Radiology 198:795–805
Yacoe ME, Sommer G, Peehl D (1991) In vitro proton spectroscopy of normal and abnormal prostate. Magn Reson Med 19:429–438
Cornel EB, Heerschap A, Smits GA, et al. (1994) Magnetic resonance spectroscopy detects metabolic differences between seven Dunning rat prostate tumour sublines with different biological behaviour. Prostate 25:19–28
Cornel EB, Smits GA, Oosterhof GO, et al. (1993) Characterization of human prostate cancer, benign prostatic hyperplasia and normal prostate by in vitro 1H and 31P magnetic resonance spectroscopy. J Urol 150:2019–24
Scheidler J, Hricak H, Vigneron DB, et al. (1999) Prostate cancer: localization with three-dimensional proton MR spectroscopic imaging–clinicopathologic study. Radiology 213:473–480
Yu K, Scheidler J, Hricak H, et al. (1999) Prostate cancer: prediction of extracapsular extension with endorectal MR imaging and three-dimensional proton MR spectroscopic imaging. Radiology 213:481–488
Vilanova JC, Barcelò J (2005) Prostate cancer detection: MR spectroscopic imaging. Abdom Imag (online first)
Aboagye EO, Bhujwalla ZM (1999) Malignant transformation alters membrane choline phospholipid metabolism of human mammary epithelial cells. Cancer Res 59:80–84
Coakley FV, Kurhanewicz J, Lu Y, et al. (2002) Prostate cancer tumour volume: measurement with endorectal MR and MR spectroscopic imaging. Radiology 223:91–97
Kurhanewicz J, Vigneron DB, Males RG, et al. (2000) The prostate: MR imaging and spectroscopy-present and future. Radiol Clin North Am 38:115–138
Amsellem-Ouazana D, Younes P, Conquya S, et al. (2005) Negative prostatic biopsies in patients with a high risk of prostate cancer: is the combination of endorectal MRI and magnetic resonance spectroscopy imaging (MRSI) a useful tool? A preliminary study. Eur Urol 47: 582–586
Mueller-Lisse UG, Swanson MG, Vigneron DB, et al. (2001) Hormone ablation of localized prostate cancer: time-dependent therapy effects on prostate metabolism detected by 3D 1H MR spectroscopy. Magn Reson Med 46:49–57
Jung JA, Coakley FV, Vigneron DB, et al. (2004) Prostate depiction at endorectal MR spectroscopic imaging: investigation of a standardized evaluation system. Radiology 233:701–708
Shukla-Dave A, Hkicak H, Eberhardt S, et al. (2004) Chronic prostatitis: MR imaging and 1H MR spectroscopic imaging findings—initial observations. Radiology 231:717–724
Casciani E, Polettini E, Bertini L, et al. (2005) Granulomatous prostatitis: a pitfall in endorectal MR imaging and 3D MR spectroscopic imaging. Eur J Radiol Extra 54: 111–114
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Casciani, E., Polettini, E., Bertini, L. et al. Contribution of the MR spectroscopic imaging in the diagnosis of prostate cancer in the peripheral zone. Abdom Imaging 32, 796–802 (2007). https://doi.org/10.1007/s00261-007-9181-9
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00261-007-9181-9