Abdominal Imaging

, Volume 29, Issue 2, pp 228–230

Fatal, complete splenic infarction and hepatic infection due to disseminated Trichosporon beigelii infection

  • S. G. Viscomi
  • K. J. Mortelé
  • V. Cantisani
  • J. Glickman
  • S. G. Silverman
Original article


We report on a 56-year-old woman with acute lymphocytic leukemia who presented with right upper quadrant pain, fever, nausea, and vomiting. Laboratory studies confirmed fungemia with Trichosporum beigelii, and contrast-enhanced computed tomography of the abdomen demonstrated numerous low-attenuation liver lesions and a hypodense spleen with capsular enhancement suggestive of complete splenic infarction. Subsequent splenectomy confirmed that the spleen was completely infarcted and infiltrated with Trichosporum. The patient had a difficult postoperative course and died despite aggressive antifungal therapy.


Computed tomography—Spleen infection—Spleen infarction—Trichosporum beigelii 


  1. 1.
    Sklair-Levy, M, Libson, Y, Lossos, IS, Bugomolsky-Yahalom, V 1998Splenic calcifications caused by Trichosporon beigelli infection: CT and ultrasound demonstration.Eur Radiol8922924PubMedCrossRefGoogle Scholar
  2. 2.
    Krcmery, V Jr, Mateicka, F, Kunova, A,  et al. 1999 Hematogenous trichosporonosis in cancer patients: report of 12 cases including 5 during prophylaxis with itraconazole.Support Care Cancer73943PubMedCrossRefGoogle Scholar
  3. 3.
    Nagai, H, Yamakami, Y, Hashimoto, A,  et al. 1999 PCR detection of DNA specific for Trichosporon species in serum of patients with disseminated trichosporonosis.J Clin Microbiol37694699PubMedGoogle Scholar
  4. 4.
    Yamagata, E, Kamberi, P, Yamakami, Y,  et al. 2000 Experimental model of progressive disseminated trichosporonosis in mice with latent trichosporonemia.J Clin Microbiol3832603266PubMedGoogle Scholar
  5. 5.
    Sidarous, MG, O’Reilly, MV, Cherubin, CE 1994 A case of trichosporon beigelii endocarditis 8 year after aortic valve replacement.Clin Cardiol17215219PubMedCrossRefGoogle Scholar
  6. 6.
    Hoy, J, Hsu, KC, Roston, K,  et al. 1986 Trichosporon beigelii infection: a review.Rev Infect Dis8959967PubMedCrossRefGoogle Scholar
  7. 7.
    Walch, TJ, Melcher, GP, Rinaldi, MG,  et al. 1990Trichosporon beigelli, an emerging pathogen resistant to amphotericin B.J Clin Microbiol2816161622Google Scholar
  8. 8.
    Walch, TJ, Newman, KL, Moody, M,  et al. 1986 Trichosporonosis in patients with neoplastic disease.Medicine65268279CrossRefGoogle Scholar
  9. 9.
    Miller, FH, Ma, JJ 2001 Total infarct due to aspergillus and AIDS.Clin Imaging255759PubMedCrossRefGoogle Scholar
  10. 10.
    Balcar, I, Seltzer, SE, Davis, S, Geller, S 1984 CT patterns of splenic infarction: a clinical and experimental study.Radiology151723729PubMedGoogle Scholar
  11. 11.
    Emery, KH 1997 Splenic emergencies.Radiol Clin North Am35831843PubMedGoogle Scholar
  12. 12.
    Freeman, JL, Jafri, SZH, Roberts, JL,  et al. 1993 CT of congenital and acquired abnormalities of the spleen.Radiographics13597610PubMedGoogle Scholar
  13. 13.
    Taylor, AJ, Dodds, WJ, Ericson, SJ, Stewart, ET 1991 CT of acquired abnormalities of the spleen.AJR15712131219PubMedGoogle Scholar

Copyright information

© Springer-Verlag New York, Inc. 2004

Authors and Affiliations

  • S. G. Viscomi
    • 1
  • K. J. Mortelé
    • 1
  • V. Cantisani
    • 1
  • J. Glickman
    • 2
  • S. G. Silverman
    • 1
  1. 1.Division of Abdominal Imaging and Intervention, Department of RadiologyBrigham & Women’s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115USA
  2. 2.Department of PathologyBrigham & Women’s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115USA

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