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Contrast enhanced MR-guided biopsy of hepatocellular carcinoma: a case report

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Abstract

Magnetic resonance (MR)–guided liver biopsy was performed in three patients with hepatocellular carcinoma. The tumor was considered (n = 2) or proven (n = 1) inaccessible with ultrasound or computed tomographic guidance. Because all lesions were poorly delineated on nonenhanced MR imaging, contrast agents (Gd-BOPTA, n = 1; ferucarbotran, n = 2) were applied to facilitate biopsy in an open low-field scanner. Postcontrast tumor conspicuity was fair in the patient receiving Gd-BOPTA and excellent in both patients receiving ferucarbotran, and biopsy was successful in all cases.

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References

  1. C Frahm HB Gehl HD Weiss WA Roßberg (1996) ArticleTitleTechnique of MR-guided core biopsy of abdominal masses using an open low-field scanner: feasibility and first clinical results. Fortschr Rontgenstr 164 62–67 Occurrence Handle1:STN:280:BymB38fptlA%3D

    CAS  Google Scholar 

  2. AJ Schmidt ST Kee DY Sze et al. (1999) ArticleTitleDiagnostic yield of MR-guided liver biopsies compared with CT- and US-guided liver biopsies. J Vasc Interv Radiol 10 1323–1329 Occurrence Handle1:STN:280:DC%2BD3c%2FkvFensw%3D%3D Occurrence Handle10584646

    CAS  PubMed  Google Scholar 

  3. L Grazioli G Morana R Caudana et al. (2000) ArticleTitleHepatocellular carcinoma.Correlation between gadobenate dimeglumine-enhanced MRI and pathologic findings Invest Radiol 35 25–34 Occurrence Handle10.1097/00004424-200001000-00003 Occurrence Handle1:STN:280:DC%2BD3c7gt1Gksw%3D%3D Occurrence Handle10639033

    Article  CAS  PubMed  Google Scholar 

  4. K Takeshita I Nagashima S Frui et al. (2002) ArticleTitleEffect of superparamagnetic iron oxide-enhanced MRI of the liver with hepatocellular carcinoma and hyperplastic nodule. J Comput Assist Tomogr 26 451–455 Occurrence Handle10.1097/00004728-200205000-00024 Occurrence Handle12016379

    Article  PubMed  Google Scholar 

  5. A Tanimoto Y Yuasa H Shinmoto et al. (2002) ArticleTitleSuperparamagnetic iron oxide-mediated hepatic signal intensity change in patients with and without cirrhosis: pulse sequence effects and Kupffer cell function. Radiology 222 661–666 Occurrence Handle11867782

    PubMed  Google Scholar 

  6. JS Lewin CA Petersilge SF Hatem et al. (1998) ArticleTitleInteractive MR imaging-guided biopsy and aspiration with a modified clinical C-arm system. AJR 170 1593–1601 Occurrence Handle1:STN:280:DyaK1c3ntVensQ%3D%3D Occurrence Handle9609180

    CAS  PubMed  Google Scholar 

  7. CW König UG Schott PL Pereira et al. (2002) ArticleTitleMR-guided lumbar sympathicolysis. Eur Radiol 12 1388–1393 Occurrence Handle10.1007/s003300101064 Occurrence Handle12042943

    Article  PubMed  Google Scholar 

  8. J Ward PJ Robinson (2002) ArticleTitleHow to detect hepatocellular carcinoma in cirrhosis. Eur Radiol 12 2258–2272 Occurrence Handle12195479

    PubMed  Google Scholar 

  9. RC Semelka AS Bagley ED Brown MA Kroeker (1994) ArticleTitleMalignant lesions of the liver identified on T1- but not T2-weighted MR images at 1.5 T. J Magn Reson Imaging 4 315–318 Occurrence Handle1:STN:280:ByuA3sblvF0%3D Occurrence Handle8061427

    CAS  PubMed  Google Scholar 

  10. NL Kelekis RC Semelka S Worawattanakul et al. (1998) ArticleTitleHepatocellular carcinoma in North America AJR 170 1005–1013 Occurrence Handle1:STN:280:DyaK1c7ptFSrsA%3D%3D Occurrence Handle9530051

    CAS  PubMed  Google Scholar 

  11. MA Kirchin GP Pirovano A Spinazzi (1998) ArticleTitleGadobenate dimeglumine (Gd-BOPTA). An overview. Invest Radiol 33 798–809 Occurrence Handle10.1097/00004424-199811000-00003 Occurrence Handle1:CAS:528:DyaK1cXnsFGrsbk%3D Occurrence Handle9818314

    Article  CAS  PubMed  Google Scholar 

  12. DV Sahani ME O’Malley S Bhat et al. (2002) ArticleTitleContrast-enhanced MRI of the liver with mangafodipir trisodium: imaging technique and results. J Comput Assist Tomogr 26 216–222 Occurrence Handle10.1097/00004728-200203000-00010 Occurrence Handle11884777

    Article  PubMed  Google Scholar 

  13. R Manfredi G Maresca RL Baron et al. (1999) ArticleTitleDelayed MR imaging of hepatocellular carcinoma enhanced by gadobenate dimeglumine (Gd-BOPTA). J Magn Reson Imaging 9 704–710 Occurrence Handle10.1002/(SICI)1522-2586(199905)9:5<704::AID-JMRI13>3.0.CO;2-Z Occurrence Handle1:STN:280:DyaK1M3mtVKisg%3D%3D Occurrence Handle10331767

    Article  CAS  PubMed  Google Scholar 

  14. P Reimer B Tombach (1998) ArticleTitleHepatic MRI with SPIO: detection and characterization of focal liver lesions. Eur Radiol 8 1198–1204 Occurrence Handle10.1007/s003300050535 Occurrence Handle1:STN:280:DyaK1czptFOqsg%3D%3D Occurrence Handle9724439

    Article  CAS  PubMed  Google Scholar 

  15. YXJ Wang SM Hussain GP Krestin (2001) ArticleTitleSuperparamagnetic iron oxide contrast agents: physiochemical characteristics and applications in MR imaging. Eur Radiol 11 2319–2331 Occurrence Handle10.1007/s003300100908 Occurrence Handle1:STN:280:DC%2BD3MnkvVygsA%3D%3D Occurrence Handle11702180

    Article  CAS  PubMed  Google Scholar 

  16. F Chen J Ward PJ Robinson (1999) ArticleTitleMR imaging of the liver and spleen: a comparison of the effects on signal intensity of two superparamagnetic iron oxide agents. Magn Reson Imaging 4 549–556 Occurrence Handle10.1016/S0730-725X(98)00193-3

    Article  Google Scholar 

  17. J Ward JA Guthrie DJ Scott et al. (2000) ArticleTitleHepatocellular carcinoma in the cirrhotic liver: Double-contrast MR imaging for diagnosis. Radiology 216 154–162 Occurrence Handle1:STN:280:DC%2BD3czksl2ltA%3D%3D Occurrence Handle10887242

    CAS  PubMed  Google Scholar 

  18. F Deckers B Corthouts Y Nackaerts et al. (1997) ArticleTitleThe influence of MR field strength on the detection of focal liver lesions with superparamagnetic iron oxide. Eur Radiol 7 887–892 Occurrence Handle10.1007/s003300050222 Occurrence Handle1:STN:280:ByiA2szmsVM%3D Occurrence Handle9228104

    Article  CAS  PubMed  Google Scholar 

  19. NM Rofsky BM Yang P Schlossberg et al. (1998) ArticleTitleMR-guided needle aspiration biopsies of hepatic masses using a closed bore magnet. J Comput Assist Tomogr 22 633–637 Occurrence Handle10.1097/00004728-199807000-00024 Occurrence Handle1:STN:280:DyaK1czktFaisQ%3D%3D Occurrence Handle9676459

    Article  CAS  PubMed  Google Scholar 

  20. JL Duerk JS Lewin M Wendt C Petersilge (1998) ArticleTitleRemember true FISP? A high SNR, near 1-second imaging method for T2-like contrast in interventional MRI at .2 T. J Magn Reson Imaging 8 203–208 Occurrence Handle1:STN:280:DyaK1c7lvF2itQ%3D%3D Occurrence Handle9500281

    CAS  PubMed  Google Scholar 

  21. YC Chung EM Merkle JS Lewin et al. (1999) ArticleTitleFast T2-weighted imaging by PSIF at 0.2 T for interventional MRI. Magn Reson Med 42 335–344 Occurrence Handle10.1002/(SICI)1522-2594(199908)42:2<335::AID-MRM16>3.3.CO;2-B Occurrence Handle1:STN:280:DyaK1MzntVektg%3D%3D Occurrence Handle10440959

    Article  CAS  PubMed  Google Scholar 

  22. RT Constable RM Henkelman (1991) ArticleTitleContrast, resolution, and detectability in MR imaging. J Comput Assist Tomogr 15 297–303 Occurrence Handle1:STN:280:By6C287ntFc%3D Occurrence Handle2002111

    CAS  PubMed  Google Scholar 

  23. J Ward F Chen JA Guthrie et al. (2000) ArticleTitleHepatic lesion detection after superparamagnetic iron oxide enhancement: comparison of five T2-weighted sequences at 1.0 T by using alternative-free response receiver operating characteristic analysis. Radiology 214 159–166 Occurrence Handle1:STN:280:DC%2BD3c7gs12gsQ%3D%3D Occurrence Handle10644117

    CAS  PubMed  Google Scholar 

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Correspondence to C. W. König.

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König, C., Trübenbach, J., Fritz, J. et al. Contrast enhanced MR-guided biopsy of hepatocellular carcinoma: a case report . Abdom Imaging 29, 71–76 (2004). https://doi.org/10.1007/s00261-003-0060-8

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