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Rate of unspecific bone uptake on PSMA PET is determined by the Scaffold – not the Radionuclide. Letter regarding: “The homunculus of unspecific bone uptakes associated with PSMA- targeted tracers: a systematic review-based definition” and “Cutting back on overdiagnosis – Occam’s razor and unspecific bone uptakes in PSMA PET“

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References

  1. van Leeuwen PJ, Donswijk M, Nandurkar R, Stricker P, Ho B, Heijmink S, et al. Gallium-68-prostate-specific membrane antigen ((68) Ga-PSMA) positron emission tomography (PET)/computed tomography (CT) predicts complete biochemical response from radical prostatectomy and lymph node dissection in intermediate- and high-risk prostate cancer. BJU Int. 2019;124(1):62–8.

    Article  PubMed  Google Scholar 

  2. Yin Y, Werner RA, Higuchi T, Lapa C, Pienta KJ, Pomper MG, et al. Follow-up of lesions with equivocal Radiotracer Uptake on PSMA-Targeted PET in patients with prostate Cancer: predictive values of the PSMA-RADS-3A and PSMA-RADS-3B categories. J Nucl Med. 2019;60(4):511–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Rizzo A, Morbelli S, Albano D, Fornarini G, Cioffi M, Laudicella R et al. The Homunculus of unspecific bone uptakes associated with PSMA-targeted tracers: a systematic review-based definition. Eur J Nucl Med Mol Imaging. 2024.

  4. Pini C, Ninatti G, Gelardi F, Sollini M, Chiti A. Cutting back on overdiagnosis - Occam’s Razor and unspecific bone uptakes in PSMA PET. Eur J Nucl Med Mol Imaging. 2024.

  5. Sheikhbahaei S, Afshar-Oromieh A, Eiber M, Solnes LB, Javadi MS, Ross AE, et al. Pearls and pitfalls in clinical interpretation of prostate-specific membrane antigen (PSMA)-targeted PET imaging. Eur J Nucl Med Mol Imaging. 2017;44(12):2117–36.

    Article  PubMed  Google Scholar 

  6. Giesel FL, Cardinale J, Schafer M, Neels O, Benesova M, Mier W, et al. (18)F-Labelled PSMA-1007 shows similarity in structure, biodistribution and tumour uptake to the theragnostic compound PSMA-617. Eur J Nucl Med Mol Imaging. 2016;43(10):1929–30.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Vollnberg B, Alberts I, Genitsch V, Rominger A, Afshar-Oromieh A. Assessment of malignancy and PSMA expression of uncertain bone foci in [(18)F]PSMA-1007 PET/CT for prostate cancer-a single-centre experience of PET-guided biopsies. Eur J Nucl Med Mol Imaging. 2022;49(11):3910–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Werner RA, Derlin T, Lapa C, Sheikbahaei S, Higuchi T, Giesel FL, et al. (18)F-Labeled, PSMA-Targeted Radiotracers: leveraging the advantages of Radiofluorination for prostate Cancer Molecular Imaging. Theranostics. 2020;10(1):1–16.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Seifert R, Telli T, Opitz M, Barbato F, Berliner C, Nader M, et al. Unspecific (18)F-PSMA-1007 bone uptake evaluated through PSMA-11 PET, bone scanning, and MRI triple validation in patients with biochemical recurrence of prostate Cancer. J Nucl Med. 2023;64(5):738–43.

    Article  CAS  PubMed  Google Scholar 

  10. Kroenke M, Mirzoyan L, Horn T, Peeken JC, Wurzer A, Wester HJ, et al. Matched-pair comparison of (68)Ga-PSMA-11 and (18)F-rhPSMA-7 PET/CT in patients with primary and biochemical recurrence of prostate Cancer: frequency of non-tumor-related uptake and Tumor Positivity. J Nucl Med. 2021;62(8):1082–8.

    Article  CAS  PubMed  Google Scholar 

  11. Jadvar H, Calais J, Fanti S, Feng F, Greene KL, Gulley JL, et al. Appropriate Use Criteria for prostate-specific membrane Antigen PET Imaging. J Nucl Med. 2022;63(1):59–68.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Gorin MA, Pomper MG, Rowe SP. PSMA-targeted imaging of prostate cancer: the best is yet to come. BJU Int. 2016;117(5):715–6.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Molecular Imaging and Therapeutics, Department of Radiology, University of North Carolina, 101 Manning Dr, Chapel Hill, NC, 27514, USA

    Steven P. Rowe

  2. The Milton and Carroll Petrie Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Michael A. Gorin

Authors
  1. Steven P. Rowe
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  2. Michael A. Gorin
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Correspondence to Steven P. Rowe.

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Conflict of interest

SPR and MAG are consultants for Lantheus Medical Imaging, Blue Earth Diagnostics, and Telix Pharmaceuticals.

Competing interests

SPR and MAG serve as consultants to Lantheus (the licensee of 18F-DCFPyL). MAG is also a consultant for Telix (a marketer of 68Ga-PSMA-11). No other relevant conflicts of interest were identified.

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Rowe, S.P., Gorin, M.A. Rate of unspecific bone uptake on PSMA PET is determined by the Scaffold – not the Radionuclide. Letter regarding: “The homunculus of unspecific bone uptakes associated with PSMA- targeted tracers: a systematic review-based definition” and “Cutting back on overdiagnosis – Occam’s razor and unspecific bone uptakes in PSMA PET“. Eur J Nucl Med Mol Imaging 51, 3767–3768 (2024). https://doi.org/10.1007/s00259-024-06897-2

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  • DOI: https://doi.org/10.1007/s00259-024-06897-2

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