Data availability
Analyzed datasets are available from the corresponding author on reasonable request.
References
Elia G, Patrizio A, Ragusa F, et al. Molecular features of aggressive thyroid cancer. Front Oncol. 2022;12:1099280. https://doi.org/10.3389/fonc.2022.1099280.
Lee YA, Lee H, Im SW, Song YS, Oh DY, Kang HJ, et al. NTRK and RET fusion-directed therapy in pediatric thyroid cancer yields a tumor response and radioiodine uptake. J Clin Invest. 2021;131. https://doi.org/10.1172/JCI144847.
Rothenberg SM, McFadden DG, Palmer EL, Daniels GH, Wirth LJ. Redifferentiation of iodine-refractory BRAF V600E-mutant metastatic papillary thyroid cancer with dabrafenib. Clin Cancer Res. 2015;21:1028–35. https://doi.org/10.1158/1078-0432.CCR-14-2915.
Groussin L, Bessiene L, Arrondeau J, Garinet S, Cochand-Priollet B, Lupo A, et al. Letter to the Editor: Selpercatinib-enhanced radioiodine uptake in RET-rearranged thyroid cancer. Thyroid. 2021;31:1603–4. https://doi.org/10.1089/thy.2021.0144.
Werner RA, Sahyeli C, Hänscheid H, et al. Successful combination of selpercatinib and radioiodine after pretherapeutic dose estimation in RET-altered thyroid carcinoma. Eur J Nucl Med Mol Imaging. 2023;50:1833–18346.
Wirth LJ, Sherman E, Robinson B, et al. Efficacy of selpercatinib in RET-altered thyroid cancers. N Engl J Med. 2020;383:825–35. https://doi.org/10.1056/NEJMoa2005653.
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Both authors contributed to the publication. The case desription was performed by Daniela Weiler, images and comments were prepared by Maria del Sol Pérez Lago. The first draft of the manuscript was written by Daniela Weiler and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
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Libretto-001 trial has ethics approval.
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Written informed consent was obtained from the patient.
Competing interests
Daniela Weiler has received speaker and consultant honoraria from Eli Lilly. Maria del Sol Pérez Lago declares no financial interests.
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Weiler, D., Pérez Lago, M. Successful radioiodine redifferentiation with selpercatinib in RET fusion-positive papillary thyroid carcinoma. Eur J Nucl Med Mol Imaging (2024). https://doi.org/10.1007/s00259-024-06747-1
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DOI: https://doi.org/10.1007/s00259-024-06747-1