Skip to main content

Advertisement

SpringerLink
Log in

Authors’ reply to Dr. Paolo Duarte: Combined [68Ga]Ga-PSMA-11 and low-dose [18F]FDG PET/CT using a long-axial field of view scanner for patients referred for [177Lu]-PSMA-radioligand therapy

  • Letter to the Editor
  • Published:
European Journal of Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Alberts I, Schepers R, Zeimpekis K, Sari H, Rominger A, Afshar-Oromieh A. Combined [68 Ga]Ga-PSMA-11 and low-dose 2-[18F]FDG PET/CT using a long-axial field of view scanner for patients referred for [177Lu]-PSMA-radioligand therapy. Eur J Nucl Med Mol Imaging. 2022. https://doi.org/10.1007/s00259-022-05961-z.

    Article  Google Scholar 

  2. Duarte PS. Letter to the editor: Combined [(68) Ga]Ga-PSMA-11 and low-dose [(18)F]FDG PET/CT using a long-axial field of view scanner for patients referred for [(177)Lu]-PSMA-radioligand therapy. Eur J Nucl Med Mol Imaging. 2022. https://doi.org/10.1007/s00259-022-06009-y.

    Article  Google Scholar 

  3. Alberts I, Hünermund J-N, Prenosil G, Mingels C, Bohn KP, Viscione M, et al. Clinical performance of long axial field of view PET/CT: a head-to-head intra-individual comparison of the Biograph Vision Quadra with the Biograph Vision PET/CT. Eur J Nucl Med Mol Imaging. 2021. https://doi.org/10.1007/s00259-021-05282-7.

    Article  Google Scholar 

  4. Wu Y, Feng T, Zhao Y, Xu T, Fu F, Huang Z, et al. Whole-body parametric imaging of (18)F-FDG PET using uEXPLORER with reduced scanning time. J Nucl Med. 2022;63:622–8. https://doi.org/10.2967/jnumed.120.261651.

    Article  CAS  Google Scholar 

  5. Hu P, Zhang Y, Yu H, Chen S, Tan H, Qi C, et al. Total-body (18)F-FDG PET/CT scan in oncology patients: how fast could it be? Eur J Nucl Med Mol Imaging. 2021. https://doi.org/10.1007/s00259-021-05357-5.

    Article  Google Scholar 

  6. Buteau JP, Martin AJ, Emmett L, Iravani A, Sandhu S, Joshua AM, et al. PSMA and FDG-PET as predictive and prognostic biomarkers in patients given [(177)Lu]Lu-PSMA-617 versus cabazitaxel for metastatic castration-resistant prostate cancer (TheraP): a biomarker analysis from a randomised, open-label, phase 2 trial. Lancet Oncol. 2022. https://doi.org/10.1016/S1470-2045(22)00605-2.

    Article  Google Scholar 

  7. Hofman MS, Emmett L, Sandhu S, Iravani A, Joshua AM, Goh JC, et al. [177Lu]Lu-PSMA-617 versus cabazitaxel in patients with metastatic castration-resistant prostate cancer (TheraP): a randomised, open-label, phase 2 trial. Lancet. 397:797–804. https://doi.org/10.1016/S0140-6736(21)00237-3.

  8. Sartor O. Invited Perspective, Outcome of patients with PSMA-PET/CT screen failure by VISION criteria and treated with 177Lu-PSMA therapy: a multicenter retrospective analysis. J Nucl Med. 2022. https://doi.org/10.2967/jnumed.122.264128.

  9. Fundytus A, Prasad V, Booth CM. Has the current oncology value paradigm forgotten patients’ time?: too little of a good thing. JAMA Oncol. 2021;7:1757–8. https://doi.org/10.1001/jamaoncol.2021.3600.

    Article  Google Scholar 

  10. Rauscher I, Fendler WP, Hope TA, Quon A, Nekolla SG, Calais J, et al. Can the injected dose be reduced in (68)Ga-PSMA-11 PET/CT while maintaining high image quality for lesion detection? J Nucl Med. 2020;61:189–93. https://doi.org/10.2967/jnumed.119.227207.

    Article  CAS  Google Scholar 

  11. McCready VR, Dizdarevic S. Nuclear medicine RIP (radiation induced phobia); improving the image. Eur J Nucl Med Mol Imaging. 2018;45:2475–7. https://doi.org/10.1007/s00259-018-4168-z.

    Article  Google Scholar 

  12. McCready VR, Dizdarevic S, Beyer T. Lesion detection and administered activity. J Nucl Med. 2020;61:1406–10. https://doi.org/10.2967/jnumed.120.244020.

    Article  Google Scholar 

  13. Alberts I, Sachpekidis C, Prenosil G, Viscione M, Bohn KP, Mingels C, et al. Digital PET/CT allows for shorter acquisition protocols or reduced radiopharmaceutical dose in [18F]-FDG PET/CT. Ann Nucl Med. 2021;35:485–92. https://doi.org/10.1007/s12149-021-01588-6.

    Article  CAS  Google Scholar 

  14. Alberts I, Prenosil G, Mingels C, Bohn KP, Viscione M, Sari H, et al. Feasibility of late acquisition [68Ga]Ga-PSMA-11 PET/CT using a long axial field-of-view PET/CT scanner for the diagnosis of recurrent prostate cancer-first clinical experiences. Eur J Nucl Med Mol Imaging. 2021;48:4456–62. https://doi.org/10.1007/s00259-021-05438-5.

    Article  CAS  Google Scholar 

  15. Gafita A, Wang H, Robertson A, Armstrong WR, Zaum R, Weber M, et al. Tumor sink effect in (68)Ga-PSMA-11 PET: myth or reality? J Nucl Med. 2022;63:226–32. https://doi.org/10.2967/jnumed.121.261906.

    Article  CAS  Google Scholar 

  16. Cook GJR, Wong WL, Sanghera B, Mangar S, Challapalli A, Bahl A, et al. Eligibility for (177)Lu-PSMA therapy depends on the choice of companion diagnostic tracer: a comparison of (68)Ga-PSMA-11 and (99m)Tc-MIP-1404 in metastatic castrate resistant prostate cancer. J Nucl Med. 2022. https://doi.org/10.2967/jnumed.122.264296.

  17. Afshar-Oromieh A, Malcher A, Eder M, Eisenhut M, Linhart HG, Hadaschik BA, et al. PET imaging with a [68Ga]gallium-labelled PSMA ligand for the diagnosis of prostate cancer: biodistribution in humans and first evaluation of tumour lesions. Eur J Nucl Med Mol Imaging. 2013;40:486–95. https://doi.org/10.1007/s00259-012-2298-2.

    Article  CAS  Google Scholar 

  18. Iravani A, Mitchell C, Akhurst T, Sandhu S, Hofman MS, Hicks RJ. Molecular imaging of neuroendocrine differentiation of prostate cancer: a case series. Clin Genitourin Cancer. 2021;19:e200–5. https://doi.org/10.1016/j.clgc.2021.01.008.

    Article  Google Scholar 

  19. Sachpekidis C, Kopka K, Eder M, Hadaschik BA, Freitag MT, Pan L, et al. 68Ga-PSMA-11 dynamic PET/CT imaging in primary prostate cancer. Clin Nucl Med. 2016;41:e473–9. https://doi.org/10.1097/RLU.0000000000001349.

    Article  Google Scholar 

  20. Afshar-Oromieh A, Sattler LP, Steiger K, Holland-Letz T, da Cunha ML, Mier W, et al. Tracer uptake in mediastinal and paraaortal thoracic lymph nodes as a potential pitfall in image interpretation of PSMA ligand PET/CT. Eur J Nucl Med Mol Imaging. 2018;45:1179–87. https://doi.org/10.1007/s00259-018-3965-8.

    Article  Google Scholar 

  21. Afshar-Oromieh A, Hetzheim H, Kubler W, Kratochwil C, Giesel FL, Hope TA, et al. Radiation dosimetry of (68)Ga-PSMA-11 (HBED-CC) and preliminary evaluation of optimal imaging timing. Eur J Nucl Med Mol Imaging. 2016;43:1611–20. https://doi.org/10.1007/s00259-016-3419-0.

    Article  CAS  Google Scholar 

  22. Afshar-Oromieh A, Hetzheim H, Kratochwil C, Benesova M, Eder M, Neels OC, et al. The theranostic PSMA ligand PSMA-617 in the diagnosis of prostate cancer by PET/CT: biodistribution in humans, radiation dosimetry, and first evaluation of tumor lesions. J Nucl Med. 2015;56:1697–705. https://doi.org/10.2967/jnumed.115.161299.

    Article  CAS  Google Scholar 

  23. Qin LP, Lv J, Li MZ, Xie LJ, Li JP, Li JF, et al. Biphasic GA 68-labeled prostate specific membrane antigen-11 positron emission tomography/computed tomography scans in the differential diagnosis and risk stratification of initial primary prostate cancer. Quant Imaging Med Surg. 2021;11:3619–28. https://doi.org/10.21037/qims-20-1312.

    Article  Google Scholar 

  24. Hoffmann MA, Buchholz HG, Wieler HJ, Rosar F, Miederer M, Fischer N, et al. Dual-time point [(68)Ga]Ga-PSMA-11 PET/CT hybrid imaging for staging and restaging of prostate cancer. Cancers (Basel). 2020;12. https://doi.org/10.3390/cancers12102788.

  25. Alberts I, Huenermund JN, Sachpekidis C, Zacho HD, Mingels C, Dijkstra L, et al. Combination of forced diuresis with additional late imaging in 68Ga-PSMA-11 PET/CT – effects on lesion visibility and radiotracer uptake. J Nucl Med. 2021:jnumed.120.257741. https://doi.org/10.2967/jnumed.120.257741.

  26. Alberts I, Sachpekidis C, Dijkstra L, Prenosil G, Gourni E, Boxler S, et al. The role of additional late PSMA-ligand PET/CT in the differentiation between lymph node metastases and ganglia. Eur J Nucl Med Mol Imaging. 2020;47:642–51. https://doi.org/10.1007/s00259-019-04552-9.

    Article  CAS  Google Scholar 

  27. Alberts I, Sachpekidis C, Gourni E, Boxler S, Gross T, Thalmann G, et al. Dynamic patterns of [(68)Ga]Ga-PSMA-11 uptake in recurrent prostate cancer lesions. Eur J Nucl Med Mol Imaging. 2020;47:160–7. https://doi.org/10.1007/s00259-019-04545-8.

    Article  CAS  Google Scholar 

  28. Alberts I, Prenosil G, Sachpekidis C, Weitzel T, Shi K, Rominger A, et al. Digital versus analogue PET in [(68)Ga]Ga-PSMA-11 PET/CT for recurrent prostate cancer: a matched-pair comparison. Eur J Nucl Med Mol Imaging. 2020;47:614–23. https://doi.org/10.1007/s00259-019-04630-y.

    Article  CAS  Google Scholar 

  29. Alberts I, Mingels C, Zacho HD, Lanz S, Schoder H, Rominger A, et al. Comparing the clinical performance and cost efficacy of [(68)Ga]Ga-PSMA-11 and [(18)F]PSMA-1007 in the diagnosis of recurrent prostate cancer: a Markov chain decision analysis. Eur J Nucl Med Mol Imaging. 2021. https://doi.org/10.1007/s00259-021-05620-9.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

    Ian Alberts, Robin Schepers, Konstantinos Zeimpekis, Hasan Sari, Axel Rominger & Ali Afshar-Oromieh

  2. Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland

    Hasan Sari

Authors
  1. Ian Alberts
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Robin Schepers
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Konstantinos Zeimpekis
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hasan Sari
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Axel Rominger
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Ali Afshar-Oromieh
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ian Alberts.

Ethics declarations

Ethical approval

This response does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

Not applicable.

Conflict of interest

The authors declare no competing interests.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This article is part of the Topical Collection on Oncology - Genitourinary

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Alberts, I., Schepers, R., Zeimpekis, K. et al. Authors’ reply to Dr. Paolo Duarte: Combined [68Ga]Ga-PSMA-11 and low-dose [18F]FDG PET/CT using a long-axial field of view scanner for patients referred for [177Lu]-PSMA-radioligand therapy. Eur J Nucl Med Mol Imaging 50, 644–647 (2023). https://doi.org/10.1007/s00259-022-06071-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00259-022-06071-6

Search

Navigation